Biomedical subjects

Lisa Bradford

Publications and source records attributed to Lisa Bradford.

3 recordsLinked to original sources

PubMed2004

Event-related potentials in young and elderly adults during a visual spatial working memory task.

The P300 event-related brain potential (ERP) was examined in 14 young (20-29 years of age) and 16 elderly (60-82 years of age) subjects during the performance of a visuospatial memory task requiring recognition of locations. Elderly and young adults exhibited similar recognition accuracy, but recognition reaction times were significantly slower in the elderly. Midline P300 amplitudes recorded in response to visuospatial probe stimuli were significantly attenuated in the elderly, and, depending on the nature of the probe, P300 latency-derived indices indicated that both cognitive and motoric slowness characterized visuospatial recognition in the aged. The results, discussed in relation to neural mechanisms supporting working memory function, suggest that alterations in attention and processing speed may play a role in visual-spatial working memory deficits associated with normal and pathological aging.

Adult↗

PubMed2003

Effects of stimulus modality and response mode on the P300 event-related potential differentiation of young and elderly adults.

The P300 event-related brain potential (ERP) was examined in 14 young (20 - 29 years of age) and 16 elderly (60 - 82 years of age) adult subjects during the performance of auditory and visual discrimination tasks requiring silent counting or key pressing in response to target stimuli. P300 latencies were longer in elderly (vs young) adults and in visual (vs auditory) tasks, and visual tasks elicited larger P300 amplitudes than auditory tasks in both age groups. Neither stimulus modality nor response mode affected P300 differentiation of young and elderly subjects. Steeper P300 anterior-posterior scalp amplitude gradients were seen in the young (vs elderly) adults, regardless of stimulus or response type. Examination of inter-subject variability with the coefficient of variation (CV) statistic found the lowest (i.e., best) CV values to be exhibited in the visual task requiring the counting of target stimuli. Implications of the findings are discussed in relation to P300 applications in the clinical assessment of dementia and aging-associated cognitive alterations.

Adult↗

PubMedDate not supplied

The Kingston Standardized Behavioural Assessment.

The Kingston Standardized Behavioural Assessment (KSBA), a behavioral screening tool that assesses the behavioral changes associated with dementia, particularly Alzheimer's disease (AD), is introduced. Designed to be user friendly for clinicians not trained in specialized behavioral assessment techniques, it addresses some of the problems of existing scales. A group of patients diagnosed with probable AD, vascular dementia, or mixed (AD and vascular) was assessed using the KSBA. A subgroup was also given the Neuropsychiatric Inventory (NPI). Behavioral profiles and scores were obtained for all subjects. Factor analysis revealed 2 factors described as neuropsychiatric and neuropsychological. The KSBA efficiently collects neuropsychological and neuropsychiatric behavioral symptoms of dementia, is easy to score and interpret, and yields a behavioral profile that helps identify target behaviors for intervention. It can be used to facilitate clinical decision making around level of care and can be easily incorporated into clinically based research.

Aged↗