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Lisa H Lowe

Publications and source records attributed to Lisa H Lowe.

8 recordsLinked to original sources
PubMed2006

Isolated filar cyst on lumbar spine sonography in infants: a case-control study.

BACKGROUND: Simple cysts found within the filum terminale of infants on lumbar spine sonography are relatively common, but no study has established their clinical significance. OBJECTIVE: To obtain information on the sonographic features of isolated filar cysts and determine their clinical significance in comparison with age- and sex-matched controls. MATERIALS AND METHODS: We performed a retrospective review of 644 consecutive spine sonograms in patients younger than 8 months. Gestational age- and sex-matched controls with normal lumbar sonograms were taken from the same period. We obtained short-term clinical follow-up of motor milestones for each group. RESULTS: The incidence of filar cyst was 78 of the 644 (11.8%) and was inversely related to age. Developmental follow-up of the study patients compared with control population showed no statistically significant difference in the ages at which the infants were able to turn over, crawl and walk. Follow-up MR imaging of 13 study patients (19%) failed to demonstrate filar cysts previously identified on sonography. CONCLUSION: No significant difference was found in the short-term outcome of infants with isolated filar cysts on lumbar sonography compared with that of a control population. Filar cysts should be considered a normal variant when found in isolation on lumbar sonography.

Age Factors↗
PubMed2006

The safety and efficacy of neuroimaging with gadoversetamide injection in pediatric patients.

OBJECTIVE: The safety and efficacy of gadoversetamide injection (OptiMARK) was examined in pediatric patients referred for magnetic resonance imaging (MRI) of the central nervous system (CNS). RESEARCH AND DESIGN METHODS: This was an open-label, multicenter study in patients aged between 2 and 18 years scheduled for a contrast-enhanced MRI study. Patients received a single injection of gadoversetamide (0.1 mmol/kg). Safety of gadoversetamide was evaluated by physical examinations and monitoring of adverse events, laboratory values, vital signs, and electrocardiogram readings before and after drug administration. Efficacy was assessed by three independent, blinded readers for confidence in diagnosis and level of conspicuity for lesion visualization on precontrast and postcontrast images. The diagnostic accuracy, sensitivity, and specificity of lesion detection were determined for the precontrast images, the postcontrast images, and the precontrast and postcontrast images read together. RESULTS: No drug-related moderate or serious adverse events were observed in this study, according to site investigators. A total of four adverse events in four of 100 patients (4%) were deemed likely related to gadoversetamide injection by the site investigators. All were mild in severity and not clinically significant. The most common adverse events, regardless of relationship to study drug, were injection-site reactions and a small prolongation of the QT interval. The administration of gadoversetamide significantly increased the level of lesion conspicuity and diagnostic confidence (p < 0.05). Compared with the nonenhanced image, gadoversetamide significantly increased the accuracy and sensitivity of lesion detection (p < 0.05). Limitations of the study included a lack of physiological measurements after sedation and prior to contrast administration, a single dose of gadoversetamide administered (0.1 mmol/kg) and patients younger than 2 years of age were excluded. CONCLUSION: The administration of gadoversetamide injection (0.1 mmol/kg) was safe, well tolerated and produced clinically appropriate contrast enhancement for MRI of the CNS in the pediatric population.

Adolescent↗
PubMed2005

Pediatric central nervous system posttransplant lymphoproliferative disorder.

Post-transplant lymphoproliferative disorder complicates approximately 1% of all renal transplants. The usual site of occurrence is within the abdomen, thorax, allograft, or head and neck. Central nervous system involvement is uncommon but, when present, occurs in isolation, sparing other organ systems. Few articles in the radiology literature have focused on the acute and follow-up central nervous system findings of the disease, especially in children. Because the clinical and imaging characteristics of central nervous system post-transplant lymphoproliferative disorder overlap those of infection and primary central nervous system lymphoma and the fact that untreated posttransplant lymphoproliferative disorder has a poor prognosis, it is important to maintain a high index of suspicion for this disorder so that appropriate treatment can be instituted.

Acyclovir↗
PubMed2005

Application of transcranial Doppler sonography in children with acute neurologic events due to primary cerebral and West Nile vasculitis.

We describe the use of serial transcranial Doppler studies to evaluate neurovascular disease in three girls presenting with acute stroke due to primary cerebral vasculitis (n = 2) and West Nile vasculitis (n = 1). Correlation of abnormal findings on transcranial Doppler sonography was compared with those of MR angiography and conventional angiography in each child. All three girls had left middle cerebral artery infarcts on MR imaging, with an abnormal left middle cerebral artery detected by MR angiography, conventional angiography, and transcranial Doppler sonography in each child. In all three cases, findings of the transcranial Doppler sonography, MR imaging, and catheter angiography were concordant.

Cerebral Angiography↗
PubMed2004

Transcranial Doppler imaging in children: sickle cell screening and beyond.

Transcranial Doppler (TCD) is widely accepted as the modality of choice for screening intracranial vessels in children with sickle cell disease. Its advantages are that it is noninvasive (no need for sedation, contrast material, or radiation), portable, easily repeated, and it provides information about the intracranial vessels that is otherwise unavailable. These positive attributes explain why in recent years the applications for TCD have grown beyond sickle cell screening to almost any disease process that involves the major intracranial vessels. The objective of this manuscript is to discuss key points on how to perform and interpret TCD, and discuss imaging features of various pathological processes such as sickle cell, asphyxia, brain trauma, brain death, hydrocephalus, enlarged subarachnoid spaces, vasospasm, vasculitis, venous sinus thrombosis, and vein of Galen malformation.

Adolescent↗
PubMed2004

Utility of follow-up renal sonography in children with vesicoureteral reflux and normal initial sonogram.

OBJECTIVE: The purpose of this study was to determine the value of follow-up renal sonography in children who presented with urinary tract infection and were found to have a voiding cystogram diagnosis of vesicoureteral reflux while having a normal initial renal sonogram. METHODS: We retrospectively reviewed the medical records of 64 consecutive children who presented for follow-up renal sonography with a voiding cystogram diagnosis of vesicoureteral reflux and a normal initial sonogram conducted as part of the routine evaluation after urinary tract infection. Data recorded included gender, age, initial grade of reflux, time to follow-up sonogram, and abnormalities on follow-up sonogram. Children with conditions that may predispose to vesicoureteral reflux were excluded. RESULTS: Children who were studied (7 boys, 57 girls) ranged in age from 1 month to 10 years, 10 months (mean: 35.6 months; median: 24 months). Ninety-four (73.4%) of 128 renal units demonstrated vesicoureteral reflux on voiding cystogram; 89 (94.7%) of 94 of them were grade 1 to 3. The mean time to follow-up was 22 months (range: 4 months to 5 years, 2 months; median: 18 months). All 128 (95% confidence interval: 0%-2.8%) renal units were normal on follow-up sonography. CONCLUSION: Routine performance of repeat sonography seems unnecessary among children, particularly girls, with low- to medium-grade vesicoureteral reflux, who have had a previous normal sonogram and no conditions that predispose to vesicoureteral reflux.

Child↗
PubMed2004

Magnetic resonance imaging and proton magnetic resonance spectroscopy of intracranial epidermoid tumors.

Intracranial epidermoid tumors or cysts are considered benign lesions. Differentiation of epidermoid tumors from arachnoid cysts is important for appropriate patient care because the treatment is different for each lesion. Arachnoid cysts can appear very similar to epidermoid tumors on computed tomography (CT). Epidermoid tumors can grow in the cerebellopontine angle (CPA) cistern, the most common location of these lesions, resulting in trigeminal neuralgia and facial paralysis. Treatment for epidermoid tumors is exclusively surgery. Arachnoid cyst, on the other hand, is a benign condition that rarely produces symptoms. Recent advances in magnetic resonance imaging (MRI) have allowed more accurate imaging diagnosis of epidermoid tumors. This article reviews the recent advances in MRI using conventional T1W, post-contrast T1W, T2W, steady-state free precession imaging, fluid-attenuated inversion recovery (FLAIR), diffusion-weighted imaging (DWI), and proton magnetic resonance spectroscopy (MRS) in the imaging diagnosis of epidermoid tumors.

Arachnoid Cysts↗