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Biomedical subjects

Lisa K Moores

Publications and source records attributed to Lisa K Moores.

9 recordsLinked to original sources
PubMed2006

Minimizing costs for treating deep vein thrombosis: the role for fondaparinux.

BACKGROUND: Deep vein thrombosis (DVT) remains a major burden and fondaparinux represents a new option for DVT therapy. We sought to determine if fondaparinux offered financial advantages over low-molecular weight heparin since it is given as a fixed dose over a wide range of patient weights rather then dosed directly on weight and because fondaparinux is not associated with heparin-induced thrombocytopenia (HIT). METHODS: We conducted a cost-minimization analysis comparing fondaparinux to enoxaparin for acute anticoagulation in DVT. We modeled a cohort of 1,000 hypothetical subjects and drew estimates for model inputs from the published literature. We completed multiple sensitivity analyses to asses the significance of our assumptions and used Monte Carlo simulation to estimate the 95% confidence intervals (CIs) around our estimation of the cost differential for the two agents. RESULTS: In the base case, total disease management costs per patient with fondaparinux are US 472 dollars compared to 769 dollars with enoxaparin. The 95% CI around this difference ranges from US 48 dollars to US 401 dollars. The model was mildly sensitive to the pharmacy acquisition costs of fondaparinux and enoxaparin which was the major driver of overall costs. Neither the rates of nor costs associated with DVT recurrence, major bleeding, nor HIT substantially affected our observations. Breakeven analysis indicated our findings to be robust over a wide range of likely clinical scenarios. CONCLUSIONS: From the perspective of a healthcare system, fondaparinux use offers an attractive economic alternative to other agents for initial DVT therapy. Expanded reliance on fondaparinux could potentially result in savings.

Body Weight↗
PubMed2006

Provider preferences for DVT prophylaxis.

BACKGROUND: Patients admitted to medicine wards are typically elderly with multiple co-morbidities, placing them at significant risk for venous thromboembolic (VTE) disease. Standard guidelines to help physicians assess risk and institute prophylaxis do not currently exist for this patient population. Our purpose was to assess how clinicians would rate a patient's risk for VTE and what recommendations they would make for prophylaxis. METHODS: Internal medicine residents and staff at a tertiary care medical center were asked to identify risk factors, evaluate VTE risk, and recommend a method of prophylaxis for patients described in eight clinical vignettes created by the authors. Each vignette was designed to represent a patient at a specific level of risk. RESULTS: 35 physicians returned the survey. Responders were able to identify some risk factors and weigh them appropriately when assigning an overall risk level. There was good agreement on risk level among responders (k=0.62) and moderate agreement comparing responders with our pre-defined gold standard (GS) (k=0.42). Compared to the GS they underestimated the level of risk almost 50% of the time. The risk level they assigned affected the type of prophylaxis recommended, with fewer low risk patients receiving any type of heparin and more high risk patients receiving low-molecular weight heparin (LMWH). CONCLUSIONS: Although internal medicine physicians are able to identify some risk factors for in-hospital VTE, they consistently underestimate the overall risk, leading to less aggressive preventative measures. Continuing education is essential to combating this preventable inpatient complication.

Adolescent↗
PubMed2004

Meta-analysis: outcomes in patients with suspected pulmonary embolism managed with computed tomographic pulmonary angiography.

BACKGROUND: Spiral computed tomographic pulmonary angiography (CTPA) is increasingly being used in the evaluation of patients with clinically suspected pulmonary embolism (PE). However, CTPA as a definitive diagnostic test may be limited by inadequate sensitivity, especially in instances of isolated subsegmental emboli. PURPOSE: To assess the safety of withholding anticoagulation in patients with suspected PE and negative results on CTPA. DATA SOURCES: All relevant studies identified in MEDLINE (1966 to March 2004) and EMBASE (1974 to 2004) and in bibliographies of key articles. The search was not limited to the English language. STUDY SELECTION: The authors selected all published studies that used CTPA to evaluate suspected PE and reported at least 3 months of follow-up in patients not receiving anticoagulation on the basis of a negative CTPA result. DATA EXTRACTION: Two reviewers independently rated study quality on the basis of predetermined criteria. Data were extracted on participants, CTPA technique, diagnostic studies performed, prevalence of PE, number of patients with negative or indeterminate CTPA results who were followed, and subsequent rates of venous thromboembolism and fatal PE. DATA SYNTHESIS: Twenty-three studies reported on 4657 patients with negative CTPA results who did not receive anticoagulation. The 3-month rate of subsequent venous thromboembolic events was 1.4% (95% CI, 1.1% to 1.8%), and the 3-month rate of fatal PE was 0.51% (CI, 0.33% to 0.76%). LIMITATIONS: The CTPA technology used varied across studies and was not applied uniformly in the same step of diagnostic algorithms. Only 1 study used CTPA as the sole diagnostic test. CONCLUSION: The rate of subsequent venous thromboembolism after negative results on CTPA is similar to that seen after negative results on conventional pulmonary angiography. It appears to be safe to withhold anticoagulation after negative CTPA results.

Angiography↗
PubMed2004

Practical utility of clinical prediction rules for suspected acute pulmonary embolism in a large academic institution.

INTRODUCTION: In an attempt to standardize clinicians' approach to the determination of pretest probability (PTP) in pulmonary embolism (PE), two simplified scoring models have recently been proposed. We sought to determine the utility of these algorithms in patients with suspected PE in a large, tertiary, academic medical center. METHODS: We performed a retrospective analysis of 295 inpatients and outpatients from our institution who were evaluated for suspected PE. Pretest probability (PTP) was calculated using two previously formulated scoring systems by Wells et al. (Canadian score) and Wicki et al. (Geneva score). Our primary endpoint was the prevalence of PE within each strata of PTP. RESULTS: The prevalence of pulmonary embolism in our cohort was 30%. The prevalence of PE in the low, intermediate and high PTP groups using the Canadian score was 15.3% (95% CI 9.5-23.7%), 34.8% (95% CI 27.9-42.4%), and 47.2% (95% CI 32.0-63.0), respectively. When compared with the low PTP group, the odds ratios of the likelihood of PE was 2.95 (95% CI 1.56-5.59) in the intermediate PTP group and 4.95 (95% CI 2.11-11.64) in the high PTP. The Wicki analysis was divided into "Geneva pure" and "Geneva presumed", where the fractional inspired oxygen concentration was known and presumed to have been sampled on room air, respectively. Neither of the Geneva scores showed statistical significance in the prevalence of PE among the PTP groups. CONCLUSIONS: The Wells' clinical prediction score is easily applied and meaningfully risk stratifies patients with suspected PE. In our population, the Geneva score was less useful.

Academic Medical Centers↗
PubMed2004

Cost-minimization analysis of two algorithms for diagnosing acute pulmonary embolism.

INTRODUCTION: Pulmonary embolism is a common disorder that often requires extensive diagnostic testing. We hypothesized that an algorithmic approach to diagnosis of pulmonary embolism based upon clinical risk stratification and D-dimer testing would be less costly than a standard approach. MATERIALS AND METHODS: We constructed a decision tree based upon two published algorithms for diagnosing acute pulmonary embolism. Branch point probabilities were obtained from the best available published literature. Costs were based upon Medicare charges. From this we obtained a base-case analysis and conducted sensitivity analysis. RESULTS: Our base-case analysis revealed that the cost-per-patient for diagnostic testing were US$216.52 for the algorithm based upon pre-test probability and D-dimer testing and US$538.62 for the standard algorithm. The cost difference per patient evaluated was US$322.10. One- and two-way sensitivity analyses did not reveal any instances in which the clinical risk algorithm was more costly than the standard algorithm. Two-way sensitivity analysis revealed several scenarios in which the standard algorithm would be less costly; however, the conditions required for these scenarios are rarely encountered in clinical practice. CONCLUSIONS: Costs of testing using an algorithm based on clinical pre-test probability and D-dimer testing are less than with a standard approach for evaluating suspected acute pulmonary embolism. This new algorithm has previously been shown to be safe and has the potential for large cost savings if widely applied.

Algorithms↗
PubMed2004

Credible threat: assessing the likelihood of a chemical or biologic attack.

Threat assessment for weapons of mass destruction is a complex task,requiring many assumptions. As a general rule, weapons of mass destruction are expensive, complex, and difficult-to-use weapons. It is not likely that any current terrorist group has the capability to strike the United States with a weapon capable of producing millions of casualties. Smaller-scale attacks with weapons of mass destruction, however. may result in significant disruption from social and psychologic changes. even though actual casualty rates would probably be quite low. It is., however, highly unlikely that any terrorist attack on the United States could completely undermine national security or threaten the survival of the United States as a nation.

Bioterrorism↗
PubMed2002

Faculty development seminars based on the one-minute preceptor improve feedback in the ambulatory setting.

OBJECTIVE: While several models of medical student instruction in the ambulatory setting exist, few have been formally studied. We wished to assess the impact of a faculty development workshop based on the One-Minute Preceptor model on the amount and quality of feedback in the outpatient setting. DESIGN: Ambulatory teaching behaviors were studied during consecutive outpatient precepting sessions before and after 3 faculty development workshops. Student-teacher interactions were assessed using audiotapes of teaching encounters coded through qualitative techniques, and surveys of teacher, learner, and patient satisfaction. SETTING: Ambulatory internal medicine clinic in a tertiary care medical center. PATIENTS/PARTICIPANTS: Nine board-certified internist faculty preceptors and 44 third-year medical students. INTERVENTIONS: Three 90-minute faculty development seminars based on the One-Minute Preceptor teaching model. MEASUREMENTS AND MAIN RESULTS: Ninety-four encounters with 18577 utterances were recorded, half before and half after the seminars. After the workshops, the proportion of utterances that contained feedback increased from 17% to 22% (P =.09) and was more likely to be specific (9% vs 15%; P =.02). After the workshops, teachers reported that the learning encounters were more successful (P =.03) and that they were better at letting the students reach their own Conclusions (P =.001), at evaluating the learners (P =.03), and at creating plans for post-encounter learning (P =.02). The workshops had no effect on the duration of the student-teacher encounter or on student or patient satisfaction with the encounters. CONCLUSIONS: Brief, interactive, faculty development workshops based on the One-Minute Preceptor model of clinical teaching resulted in modest improvements in the quality of feedback delivered in the ambulatory setting.

Ambulatory Care↗