Clinical trial trouble: did the right thing.
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Animal Care Committees↗
Biomedical subjects
Lori R Hill
Publications and source records attributed to Lori R Hill.
Pig surgery: can reduction be a protocol violation?
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Animal Care Committees↗
SHIV transmission and susceptibility to re-exposure through social contact following vaccination with an HIV synthetic peptide-cocktail: a case study.
An effective vaccine against human immunodeficiency virus (HIV) should not only protect from infection and development of acquired immunodeficiency syndrome (AIDS), but also prevent potential transmission to naïve partners. We recently reported protection of rhesus macaques from chronic simian-human immunodeficiency virus (SHIV) infection and AIDS by an HIV envelope peptide-cocktail vaccine. In the present case study, we observed that one of the vaccinated females, with undetectable circulating virus, when housed in a pair with a naïve male, did not transmit the infection over a 35-week period of social contact. Subsequent experimental challenge of the male with the same SHIV strain resulted in high-level infection and transmission to its female cage-mate. However, the virus was undetectable in the female by 12 weeks without further vaccination, validating the multivalent peptide cocktail vaccine approach in the SHIV-rhesus model, and suggesting its potential utility as an HIV vaccine strategy for humans.
AIDS Vaccines↗
A simple, inexpensive method to minimize floor-drain obstructions while supporting environmental enrichment in primate facilities.
An important component of nonhuman primate environmental enrichment programs is affording the animals the opportunity to manipulate objects. Although these objects and various bulky food items enrich the quality of life for nonhuman primates, they complicate the duties of facility maintenance personnel. A prime example of these sometimes costly complications is a seemingly never-ending series of floor drain obstructions. We devised a simple, inexpensive modified drain cover that prevents large items from entering the drain. The total cost of materials for this device was 1.12 dollars, and it required only 15 min of labor for assembly. The design and implementation of this modified drain cover illustrate why the interaction between physical-plant personnel and animal-care personnel is key to the operation of a successful animal care and use program and proper maintenance of laboratory animal facilities.
Animal Welfare↗
Perineal swellings in two strains of mice.
Seven adult male mice of two different strains and from two different animal housing facilities were submitted for necropsy to evaluate unilateral or bilateral swellings in the ventral perineal area. On dissection, the swellings were oval to spherical cystic structures located near the base of the penis. Striated muscle and a delicate stroma encapsulated all cystic structures. Cysts were firm, tan, and filled with clear, yellow fluid, or were softer and filled with white, amorphous, marbled material and a smaller amount of clear, yellow fluid. Evaluation of the cysts led us to a diagnosis of cystic bulbourethral (or Cowper s) glands. Possible causes and the incidence of this condition in other species are discussed.
Animals↗