Biomedical subjects

Lorraine G. Shapeero

Publications and source records attributed to Lorraine G. Shapeero.

3 recordsLinked to original sources

PubMed1999

Dynamic Contrast-Enhanced MR Imaging for Soft Tissue Sarcomas.

Dynamic contrast-enhanced magnetic resonance imaging has recently emerged as an important method for evaluating soft tissue sarcomas for biopsy localization, chemotherapeutic response, and long-term follow-up because of its ability to detect viable tumor. This article presents the basic principles of contrast kinetics in soft tissue sarcomas after bolus injection of contrast agent and discusses the current postprocessing methods (subtraction, first-pass image and time-intensity curves with region of interest, and color-encoded techniques) used to display these dynamic studies. Because of its excellent temporal resolution, dynamic MR imaging can delineate the early uptake of contrast agent in sarcomas within seconds after injection, almost synchronous with arterial enhancement, and thereby differentiate the rapidly enhancing viable tumor from the nonenhancing necrotic tumor and the late enhancing changes after surgery, radiation therapy, and chemotherapy.

Journal Article↗

PubMed1999

MR Imaging in the Follow-Up Evaluation of Aggressive Soft Tissue Tumors.

Although newer imaging techniques aid in the diagnosis of soft tissue sarcomas and current surgical procedures and adjunct therapy decrease the incidence of their recurrences when patients are referred to oncologic centers, the majority of these tumors are suboptimally evaluated in general practice with frequent recurrences. Close surveillance of these patients is necessary for early recognition and treatment of recurrent disease. This article describes an organized, stepwise magnetic resonance imaging evaluation of these patients after surgery and radiation therapy. The initial sequence should be T2-weighted. Low signal intensity or diffuse high signal intensity without mass on T2-weighted sequence excludes recurrence in 99% of patients. A high signal intensity mass, however, should be studied with bolus injection of contrast medium. Although standard contrast-enhanced MR imaging differentiates the non-enhancing hygroma or hematoma from the enhancing recurrence or pseudotumor, dynamic contrast-enhanced MR imaging is required to distinguish the rapidly enhancing recurrent tumor from the slowly enhancing pseudotumor of inflammation.

Journal Article↗

PubMed1999

An Algorithm for Soft Tissue Tumors: Current Perspectives.

The diagnosis and treatment of soft tissue sarcomas has dramatically changed in the last 10 to 15 years with more precise preoperative diagnosis, resection, adjunct therapy, and long-term follow-up. With correct preoperative diagnosis and staging of a soft tissue sarcoma, the surgeon, in conjunction with the radiation therapist and the medical oncologist, can select the optimal therapeutic approach to minimize the development of recurrences and metastases. Recognition of a mass as benign or non-neoplastic prevents unnecessary surgery. This article presents an algorithm that demonstrates the important interactions and contributions of the various oncologic-related disciplines (surgery, radiology, pathology, medical oncology, and radiation therapy) to the care of patients with soft tissue tumors.

Journal Article↗