Biomedical subjects

Luciana Reis Azevedo

Publications and source records attributed to Luciana Reis Azevedo.

5 recordsLinked to original sources

PubMed2006

Quantitative age-related differences in human sublingual gland.

OBJECTIVE: To quantify morphological age- and gender-related differences in human sublingual glands (SLG). DESIGN: Ninety right human SLG from necropsies were distributed by gender and age groups. Individuals with ages ranging from 7 months to 92 years were divided into Groups I (0-30 years), II (31-60 years) and III (61-92 years). The glandular volume of each SLG was calculated. The morphometric quantifications of the volume density and total volume of acini, ducts, stroma, adipose tissue and septa were realized under light microscopy using a Zeiss II integration grid with 100 points symmetrically distributed. RESULTS: The glandular volume decreased, on average, 33.78% across the groups. The volume density (V(V)) of acini reduced 60.54% and of septa 34.82%, being replaced partly by an increase of 58.82%, 551.22% and 2,783.33% in the volume density of ducts, stroma and adipose tissue, respectively. In absolute terms, with aging, the total volume (V(T)) of the acini decreased by 54.04% and by 34.84% in the septa. In contrast, the total volume of ducts, stroma and adipose tissue showed increases of 62.53%, 363.25% and 2,308.64%, respectively. Both the V(V) and the V(T) of acini, ducts, stroma and adipose tissue and the V(V) of septa were statistically different with age. No significant difference was observed between genders. CONCLUSION: The decrease of parenchyma accompanied by an increase of stroma observed here in SLG is a common feature of aging in human salivary glands.

Adipose Tissue↗

PubMed2006

Odontogenic myxoma--a case report and clinico-radiographic study of seven tumors.

The primary aim of this paper is to present clinical and radiographic aspects of odontogenic myxomas diagnosed at the Stomatology Clinic of Bauru School of Dentistry, University of São Paulo, Brazil and to compare them with data reported in a series published in the literature. A second objective is to report a clinical case of odontogenic myxoma in a 9-year-old patient in whom the lesion involved the anterior region of the maxilla. Dental records between 1975 and 2000 were reviewed and seven cases diagnosed as odontogenic myxoma were found in individuals aged from nine to 60 years. Of these, four occurred in women and three in men. The mandible was affected in five cases and the maxilla in two. All patients presented with asymptomatic swelling in the affected area. A mixed radiographic result was observed in five patients, while in two patients the lesion was completely radiolucent. The borders of the lesion were well-defined in six patients. In four cases there was dental displacement, although root resorption was not observed in any of these. The treatment of choice was surgical excision. Four cases did not recur during the period of follow-up, which varied from nine months to 19 years. It was concluded the clinico-radiographic study of odontogenic myxomas should be continually refined with the aim of offering the patient an appropriate treatment, since the lesion presents a high potential for recurrence.

Adolescent↗

PubMed2005

Age-related changes in human sublingual glands: a post mortem study.

OBJECTIVES: To analyse age- and gender-related microscopic changes in sublingual glands obtained from human cadavers. STUDY DESIGN: One hundred eighty six human sublingual glands were obtained from 93 autopsies. Approximately five individuals of each gender per decade of life were allocated to three age groups: group I (0-30 years, n=26); group II (31-60 years, n=32) and group III (61-90 years, n=35). The specimens were fixed in 10% formalin and submitted to routine histological processing, and sections were stained with hematoxylin and eosin. RESULTS: Significant differences with increasing age were observed for the following microscopic aspects: acinar atrophy (r=0.26, p=0.0115); replacement of parenchyma by fibrous tissue (r=0.79, p<0.0001) and/or adipose tissue (r=0.63, p<0.0001); oncocytosis (r=0.61, p<0.0001); duct-like structures (chi(2)=14.68, p=0.0006) and congested blood vessels (chi(2)=7.18, p=0.0276). The mononuclear infiltrate changed from focal to diffuse with age (H=8.47, p=0.0144). No significant differences were observed between genders. CONCLUSIONS: The aging process starts with acinar atrophy, followed by the presence of duct-like structures and ends with the replacement of the parenchyma by fibrous and/or adipose tissue. The mononuclear infiltrate changes from focal to diffuse. No difference in the aging of the sublingual glands is observed between men and women.

Adolescent↗

PubMed2004

Orthodontic therapy in a patient with white sponge nevus.

An undesirable effect of fixed orthodontic appliances is irritation of the oral mucosa. Lesions are common, but they usually heal quickly because of the fast metabolism of oral mucosa cells. Alterations accompanying some injuries are temporary, but some are irreversible because of attrition. White sponge nevus constitutes a special situation, and little information about it is available in the orthodontic literature. This report presents a patient with white sponge nevus who received orthodontic treatment over a 40-month period. The condition was also noted in a sibling. Because of the similarity between white sponge nevus and other diseases, including some that are malignant, a thorough clinical history and differential diagnosis are essential.

Adolescent↗

PubMed2004

Glandular odontogenic cyst: case report and review of the literature.

Glandular odontogenic cyst (GOC) is a rare developmental cyst of the jaws. It is included in the World Health Organization (WHO) histologic typing of odontogenic tumors under the terms glandular odontogenic cyst or sialo-odontogenic cyst. The most common site of occurrence is the anterior mandible, and it occurs mostly in middle-aged people. A predilection for men is observed. Clinical findings are not specific, and an asymptomatic swelling is frequently observed. A unilocular or multilocular, well-defined radiolucency is usually seen. The microscopic features of GOC, particularly the morphology of the epithelium, strongly suggest an origin from the remains of dental lamina. GOC has an unpredictable and potentially aggressive nature, which may indicate a high tendency of recurrence. The treatment of choice is still controversial, varying from a curettage to local block excision. A long-term follow-up should be carried out. The aim of this article is to report a case of glandular odontogenic cyst that recurred four times and to emphasize the importance of long-term follow-up. The origin, epidemiology, clinical and radiographic aspects, and treatment of the GOC are also discussed.

Adult↗