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Lucy Miller

Publications and source records attributed to Lucy Miller.

5 recordsLinked to original sources
PubMed2006

Visualizing three-dimensional facial soft tissue changes following orthognathic surgery.

Laser scanning can be used to visualize the face in three dimensions. These scans can then be processed to enable assessment of facial changes. The aim of this single-centre, prospective, longitudinal, cohort study was to investigate whether four different visualization methods correctly represented facial changes occurring as a result of orthognathic surgery. Twenty-six consecutive orthognathic patients (13 female mandibular advancement and 13 male bimaxillary Class III) were included as well as a control group of 12 non-growing adults (6 males and 6 females). Pre- and post-operative facial laser scans were superimposed and four different visualization methods applied: correspondences with sensitivity to movement, normals, radial, and closest point. A group of 10 'blinded' observers determined the surgical procedure (if any) that had been performed by applying a specific colour scale to each facial image. The sensitivities and specificities for each visualization method applied to each subject group were determined. The intraobserver repeatability was investigated using Cohen's kappa (k). The radial method was found to be superior for identifying mandibular advancement patients (sensitivity/specificity 58.5/92.4 per cent), the normals method for visualization of bimaxillary Class III cases (26.2/99.6 per cent), while the control group was best represented using the closest point (60.0/80.8 per cent). Overall, intraobserver repeatability was good (k = 0.61). A good level of repeatability was demonstrated in the separate subject groups (mandibular advancement 0.70, bimaxillary Class III 0.70, and controls 0.62). There was no significant difference in the abilities of the four visualization methods to represent facial changes. Each method allowed correct identification of different proportions of the subject groups.

Adolescent↗
PubMed2004

Audit of head injury management in Accident and Emergency at two hospitals: implications for NICE CT guidelines.

BACKGROUND: The National Institute for Clinical Excellence (NICE) has produced guidelines on the early management of head injury. This study audits the process of the management of patients with head injury presenting at Accident and Emergency (A&E) departments and examines the impact upon resources of introducing NICE guidelines for eligibility of a CT scan. METHODS: A retrospective audit of consecutive patients of any age, presenting at A&E with a complaint of head injury during one month in two northern District General Hospitals forming part of a single NHS Trust. RESULTS: 419 patients presented with a median age of 15.5 years, and 61% were male. 58% had a Glasgow Coma Score (GCS) recorded and 33 (8%) were admitted. Only four of the ten indicators for a CT scan were routinely assessed, but data were complete for only one (age), and largely absent for another (vomiting). Using just three (incomplete) indicators showed a likely 4 fold increase in the need for a CT scan. CONCLUSIONS: The majority of patients who present with a head injury to Accident and Emergency departments are discharged home. Current assessment processes and associated data collection routines do not provide the information necessary to implement NICE guidelines for CT brain scans. The development of such clinical audit systems in a busy A&E department is likely to require considerable investment in technology and/or staff. The resource implications for radiology are likely to be substantial.

Adolescent↗
PubMed2004

Impact of a physiologic definition on bronchopulmonary dysplasia rates.

OBJECTIVE: Bronchopulmonary dysplasia (BPD) is the endpoint of many intervention trials in neonatology, yet the outcome measure when based solely on oxygen administration may be confounded by differing criteria for oxygen administration between physicians. We previously reported a technique to standardize the definition of BPD between sites by using a timed room-air challenge in selected infants. We hypothesized that a physiologic definition of BPD would reduce the variation in observed rates of BPD among different neonatal centers. Methodology. A total of 1598 consecutive inborn premature infants (501-1249 g birth weight) who remained hospitalized at 36 weeks' postmenstrual age were prospectively assessed and assigned an outcome with both a clinical definition and physiologic definition of BPD. The clinical definition of BPD was oxygen supplementation at exactly 36 weeks' postmenstrual age. The physiologic definition of BPD was assigned at 36 +/- 1 weeks' postmenstrual age and included 2 distinct subpopulations. First, neonates on positive pressure support or receiving >30% supplemental oxygen with saturations between 90% and 96% were assigned the outcome BPD and not tested further. Second, those receiving < or =30% oxygen or effective oxygen >30% with saturations >96% underwent a room-air challenge with continuous observation and oxygen-saturation monitoring. Outcomes of the room-air challenge were "no BPD" (saturations > or =90% during weaning and in room air for 30 minutes) or "BPD" (saturation <90%). At the conclusion of the room-air challenge, all infants were returned to their baseline oxygen levels. Safety (apnea, bradycardia, increased oxygen use) and outcomes of the physiologic definition versus the clinical definition were assessed. RESULTS: A total of 560 (35.0%) neonates were diagnosed with BPD by the clinical definition of oxygen use at 36 weeks' postmenstrual age. The physiologic definition diagnosed BPD in 398 (25.0%) neonates in the cohort. All infants were safely studied. There were marked differences in the impact of the definition on BPD rates between centers (mean reduction: 10%; range: 0-44%). Sixteen centers had a decrease in their BPD rate, and 1 center had no change in their rate. CONCLUSIONS: The physiologic definition of BPD reduced the overall rate of BPD and reduced the variation among centers. Significant center differences in the impact of the physiologic definition were seen, and differences remained even with the use of this standardized definition. The magnitude of the change in BPD rate is comparable to the magnitude of treatment effects seen in some clinical trials in BPD. The physiologic definition of BPD facilitates the measurement of BPD as an outcome in clinical trials and the comparison between and within centers over time.

Apnea↗