Biomedical subjects

Ludovic Josien

Publications and source records attributed to Ludovic Josien.

3 recordsLinked to original sources

PubMed2003

Synthesis and crystal structure of IM-6, a new open framework cobalt-gallium phosphate with ten- and twelve-membered pore openings.

A new three-dimensional microporous cobalt-gallium phosphate, named IM-6, has been synthesized under solvothermal conditions with an N-substituted piperazine as organic template. The structure was solved by single-crystal X-ray diffraction (triclinic, P(-)1, a=9.848(20), b=12.470(32), c=12.603(28)A, alpha=63.47(16) degrees, beta=74.56(16) degrees, gamma=76.03(17) degrees). IM-6 exhibits a new framework topology. The inorganic framework is built up of MO(4) (M=Co, Ga) and PO(4) tetrahedra. It displays a two-dimensional interconnected channel system running along the [0(-)11] and [100] directions and delimited by ten- and twelve-membered ring openings, respectively.

Journal Article↗

PubMed2002

Easy access to phosphonothioates.

A new and particularly mild method for the formation of phosphorus-sulfur bonds has been achieved through base-catalyzed addition of thiocyanate to the corresponding H-phosphine oxide, phosphinate, or phosphonate. This reaction procedure offers many advantages: the use as starting material of a stable and not oxygen-sensitive phosphorus(v) species, particularly mild and nonaqueous reaction conditions and workup (a pivotal point for these sensitive phosphonothioates), and, through optimized access to thiocyanates, a wider scope of substrates. This method has been applied to achieve the synthesis of substrate analogues for the study of antibody-catalyzed hydrolysis of acetylcholinesterase inhibitor PhX (11).

Cholinesterase Inhibitors↗

PubMed2002

Hydrothermal synthesis and characterization of the new layered fluorogallophosphate mu-23.

Mu-23, [(C(6)H(15)N(2))(C(6)H(16)N(2))Ga(5)F(6)(H(2)O)(2)(PO(4))(4)] x 4 H(2)O, the first layered fluorinated gallophosphate with a Ga/P molar ratio of 5:4, was obtained in the presence of fluoride ions with 1,4-dimethylpiperazine as an organic template. It crystallizes in the triclinic space group P1 (no. 2) with unit cell parameters a=8.735(11), b=8.864(5), c=12.636(10) A, alpha=98.36(5), beta=100.18(8), gamma=115.84(7) degrees. The layers consist of GaO(2)F(3)(H(2)O), GaO(4)F(2) octahedra, and GaO(4) and PO(4) tetrahedra; these moieties share their oxygen and some of their fluorine atoms. The connectivity scheme of these different polyhedra leads to the formation of eight-membered rings.

Journal Article↗