Important bias in the Astragalus meta-analysis.
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Biomedical subjects
Publications and source records attributed to Luigi Gori.
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We analyzed Internet information about herbal products and dietary supplements regulated by Ministry of Public Health. We screened 522 Italian web sites and we found information about toxic risks on Germander (Teucrium chamaedrys), Red yeast fermented rice (Monascus ruber), Borage (Borago officinalis) and Coltsfoot (Tussilago farfara) respectively in: 63%, 47%, 3% and 22% of the web sites. It is also possible the on-line purchase. Results show that in Internet there are not correct instructions about risks of herbal products.
In the last years, the word "posturology" has been used in complementary medicine to define the discipline studying the relation between posture and many pathologies, above all chronic pain. Posturology is more and more frequently recommended as a diagnostic-therapeutic system for treatment of chronic complaints, on the base of which different health caregivers (physicians and not) treat the same clinical problem, with very different methodological patterns and therapies. If it is true that many scientific papers highlight a relation between body posture and muscoloskeletal disorders; nevertheless on the base of scientific literature, it is not possible to demonstrate any scientific principle showing that the correction of small alterations of posture on the base of a stabilometric analysis can improve muscoloskeletal pain or other diseases. Rather, it is true the opposite. Today a positive stabilometric test can be referred only to an alteration of the vestibulo-spinal system.
In every country traditional medicines find foundation in magical or religious beliefs, or popular experience. The World Health Organization is engaged to establish guidelines for methodology of clinical research and the appraisal of effectiveness of traditional medicine. In Italy it has been adopted the term non-conventional medicines in order to group one series of therapies and medicines which are radically different one from the other. Phytotherapy uses medicinal plants prepared by means of adapted extractive technologies and proper pharmacological preparations, purified and standardized in their chemical principles. As for any shape of therapy there are possible side effects, contraindications, pharmacological interactions. It is deemed necessary that a basic knowledge of the pharmacological aspects of phytotherapy be included in the regular Course of Medicine.
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Liquorice, a medicinal plant of the Italian pharmacopoeia, can give rise to adverse reactions and drugs interferences. On the main international scientific databases we made an "all years" search to find out case reports dealing with rhabdomyolisis due to liquorice ingestion. We found 77 cases, 7 of which in Italy.
Flavonoids are polyphenolic compounds that occur ubiquitously in fruits and vegetables. Over 4,000 different flavonoids have been described, and they are categorized into flavonols, flavones, catechins, flavanones, anthocyanidins and isoflavonoids. Flavonoids have many different biological effects in numerous mammalian cell systems, showed both in vitro and in vivo. Recently, much attention has been paid to their antioxidant properties and to their inhibitory role in various stages of tumour development in animal studies. In epidemiological studies the intake of flavonoids was inversely associated with subsequent coronary heart disease and cancer. Soy, St. John's Wort, Silybum marianum, Ginkgo biloba, Citrus species, Vaccinum mirtillus, Hawthorn and tea are medicinal plants containing flavonoids whose efficacy in the treatment of a variety of diseases has been demonstrated in numerous clinical studies. The main question that has not been answered satisfactorily deal with the triad absorption/metabolism/efficacy of flavonoids and is actually an important unsolved problem in judging their many alleged health effects. The aim of this review is based on providing by means of experimental and clinical studies information about efficacy and toxicity of flavonoids, especially focusing on infantile leukaemia for which there has been an international warning without sufficient and affordable scientific data.