Biomedical subjects

Luiz César Peres

Publications and source records attributed to Luiz César Peres.

3 recordsLinked to original sources

PubMed2006

Histopathologic changes in human true vocal folds: a postmortem study.

Several articles describe the gross pathology alterations of the true vocal cords (TVC), but the histopathology descriptions in adults are rare in the literature and are normally associated with neoplasia. The aim of this study is to identify the TVC morphological lesions in adult autopsies. This was a cross-sectional study of 266 adults' larynxes consecutively autopsied from 1993 to 2003. Histochemical and immunohistochemical methods were used for morphological analysis. Considering the morphological analysis, 97 TVC (36.5%) were considered normal. The following lesions were found in the TVC: thickening of the basal membrane of the TVC in 81 patients (30.5%), inflammatory reaction in 66 patients (24.8%), hemorrhage in 19 patients (7.1%), and ulceration in 3 patients (1.1%). Our study demonstrated that the TVC microscopic lesions are frequent, present different morphological patterns, and showed different causes from what had been described until nowadays by the literature. Despite this difference in the morphological pattern, we were able to identify a common lesion pathway for ethiological different diseases.

Adult↗

PubMed2004

Adult-type hypolactasia: clinical, morphologic and functional characteristics in Brazilian patients at a university hospital.

BACKGROUND: Adult-type hypolactasia (AH) is the most common form of disaccharidase deficiency in humans, with a prevalence that varies among ethnic groups. In Brazil, the few available studies suggest a high prevalence of this condition. The objective of this study was to determine the prevalence of AH in Brazilian patients at the Ribeirão Preto University Hospital, and to study its morphologic and functional expression. METHODS: One hundred fifteen patients between 5 and 60 years undergoing upper gastrointestinal endoscopy were included. Mucosal biopsy specimens were obtained from the second portion of the duodenum. AH was defined by the disaccharidase activity (lactase/sucrase ratio) of the duodenal mucosa. The morphologic expression of lactase was studied by immunohistochemistry. RESULTS: The mean age of the subjects was 28.8 +/- 14.8 years. Seventy of the 115 subjects (60.8% prevalence) had AH by enzyme activity measurements. Milk drinking was common and similar in patients with and without AH. Among the patients, 91.3% of the nonwhite and 53.2% of the white individuals had hypolactasia (P = 0.002). Immunohistochemistry revealed the presence of lactase in 73.3% of individuals with normal lactase activity. Two different expression patterns were found in patients with AH. CONCLUSIONS: The prevalence of AH was high in our subjects and similar to that reported in other Brazilian studies. Hypolactasia was more common among nonwhites. Immunohistochemistry permitted the identification of two phenotypes of AH, the first characterized by the absence of both stainable lactase and lactase activity, and the second by the presence of stainable lactase without significant activity.

Adolescent↗

PubMedDate not supplied

[Assessment of educational objectives in two different curricular structures--Faculty of Medicine of Ribeiráo Preto, University of São Paulo, Brazil].

OBJECTIVE: The objective of the study was to assess the impact of the curricular change on the achievement of the educational objectives of the institution, analyzing the performance of graduating students, from the Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil. METHODS: Techniques of recognized validity and reliability (MCQ, OSCE, PMP) were used for the evaluation of skills and competence in the cognitive, psychomotor and clinical domains. Three of the 3 final years classes educated according to the previous curricular structure (n=222) and three classes educated according to the new curricular structure (n=261) were evaluated during the study period. RESULTS: The performance of graduating students in these different tests permitted us to estimate the extent of achievement of 17 of the 36 intermediate educational objectives of the institution in the two curricular structures. Comparison of the two curricula demonstrated the absence of significant differences in the extent of achievement of ten of the 17 objectives. For six of the seven remaining objectives a significant increase (p<0.05) in the extent of achievement was observed with the new curricular structure. CONCLUSIONS. The results indicate that the new curricular structure was associated with a better performance of the students in cognitive skills related to general practice and in basic clinical and psychomotor skills.

Brazil↗