For whom CME programme organised.
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Developed Countries↗
Biomedical subjects
M A Abdulla
Publications and source records attributed to M A Abdulla.
Cytodiagnosis of nipple discharge: a study of 602 samples from 484 cases.
To find out the gross and microscopic differentiating features between nipple discharges (ND) due to various breast lesions, smears of 602 ND samples from 484 cases were reviewed by one of the investigators (D.K.D.). The reviewed cytodiagnoses were as follows: benign nipple discharge (59.1%), inflammatory ND (6.5%), ?papillary lesions (2.5%), papillary lesions (20.6%), papillary lesions with atypia (3.8%), duct cells with atypia (0.2%), suspicious for malignancy (0.5%), malignant ND (1.2%), and inadequate (5.6%). Following review, samples with epithelial abnormalities (?papillary lesion, papillary lesion with and without atypia, duct cells with atypia, suspicious for malignancy, and malignancy) increased from 16.6% to 30.4% of adequate samples (P < 0.0001). 37.9% unilateral ND samples showed epithelial abnormalities, as opposed to 18.9% of bilateral ND samples (P < 0.0001). Bloodstained ND showed epithelial abnormalities in 41.5% samples, as compared to 22.1% of ND with other specified gross characteristics (P < 0.0001). The samples with epithelial abnormalities differed significantly from benign and inflammatory ND in respect of frequency of benign duct cells, duct cells with atypia, papillary clusters with or without atypia, malignant cells, columnar cells, red blood cells, inflammatory cells, and background lipid vacuoles (P < 0.01 to < 0.0001). The ND samples with suspicious and malignant cytology, besides the presence of malignant cells (P < 0.0001), differed significantly from rest of the lesions in respect of foam cells (P < 0.0001), red blood cells (P < 0.01), and inflammatory cells (P < 0.05). When compared with histopathological diagnosis in 20 cases, the benign or malignant nature of the lesion was correctly identified in ND in 80% cases. The ND cytologies in 7 histologically proved malignant cases were malignancy (3 cases), suspicious for malignancy (1 case), papillary lesion with atypia (1 case), papillary lesion (1 case), and benign ND (1 case).
Breast Diseases↗
Comparison of ThinPrep and conventional preparations: urine cytology evaluation.
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Evaluation Studies as Topic↗
Loss and regeneration of the microvilli of human placental syncytiotrophoblast.
In order to explore the functional role of microvilli of the syncytiotrophoblast of the human full-term placenta, 16 placentas were examined by scanning electron microscopy (SEM). Our results showed that the microvilli projecting from the apical portion of the syncytiotrophoblast appeared to be highly pleomorphic and showed regional variations in their distribution. This has been correlated to the difference in the stage of growth of microvilli following certain obvious examples of loss. Such a process of distortion and renewal or regeneration may suggest a dynamic functional activity of the microvilli on the villous surface.
Female↗
Loperamide in acute diarrhoea in childhood: results of a double blind, placebo controlled clinical trial.
Fifty-three young children with acute diarrhoea were included in a hospital-based, double-blind trial of loperamide at two dose levels (0.4 and 0.8 mg/kg/day), given with standard oral rehydration therapy versus placebo plus oral rehydration therapy. The differences in the overall recovery rate were significant (P less than 0.05), the fastest being in the group given 0.8 mg/kg and slowest in the placebo group. Comparison between weights on admission and weights by day 3 showed that more children in the loperamide groups gained weight than in the placebo group (P less than 0.05). No serious side effects of loperamide were observed. The drug was withdrawn in one child because of excessive lethargy and sleep. The results indicate that loperamide in the doses employed is safe and may be a useful adjunct to oral rehydration in certain children.
Child, Preschool↗
Distribution and ultrastructural characterization of the stroma in scirrhous 'infiltrating' carcinoma of the human breast.
A combination of light microscopic, histochemical, immunohistochemical and transmission electron microscopic techniques were used to study the distribution and ultrastructural characterization of the stroma of Scirrhous 'infiltrating' carcinoma of the human breast. Both the light and electron microscopic techniques emphasized the presence of regional variations in the distribution of fibrous tissue in this type of tumour. Whilst fibronectin and collagen type III appeared relatively rich in both periductal and diffused regions, there was a clear contrast in the distribution of collagen type I and elastic tissue between the two regions. Collagen type I was more numerous in the diffused regions whereas elastic tissue was more produced in the periductal regions. The present study confirmed the views that Scirrhous carcinoma cells secrete inappropriately the majority of collagen, elastic and possibly other fibrillar elements of the connective tissue stroma. Fibroblasts, myofibroblasts and myoepithelial cells are believed to contribute in a minor way to the production of the various connective tissue elements. Finally, our findings have been discussed in relation to the mechanism of invasiveness of the tumour cells.
Breast Neoplasms↗
Tropical pyomyositis in Saudi Arabia.
Tropical pyomyositis is a disease of skeletal muscle characterised by single or multiple abscesses with Staphylococcus aureus the most commonly isolated organism. Most cases have been reported from the hot and humid tropics. This report reviews the literature, describes a case from hot, dry Saudi Arabia and suggests that such cases may be missed because local clinicians may be unaware of the existence of such a clinical entity.
Abscess↗
Preparation of void-free casts from vinyl polysiloxane impressions.
PURPOSE: To investigate two techniques to produce void-free casts from vinyl polysiloxane impressions. MATERIALS AND METHODS: Thirty casts prepared using a conventional technique were compared with 30 casts prepared using a technique involving syringing of stone in terms of numbers of surface voids. RESULTS: Significantly fewer surface voids were observed in the casts prepared using syringing technique. CONCLUSION: The syringing technique investigated is considered to have advantages over the conventional technique for the production of casts from vinyl polysiloxane impressions.
Air↗
Fine needle aspiration biopsy of azoospermic testes. Could it replace histologic biopsy?
OBJECTIVE: To evaluate the possibility of replacing histologic biopsy of azoospermic testes by fine needle aspiration (FNA) for diagnostic and management purposes. STUDY DESIGN: Twenty-seven patients were examined under general anesthesia, and 53 testes were biopsied by FNA. Fifty-four testes were biopsied for histologic examination. Histology and cytology of each testis were compared to assess the discrepancy or concordance between the diagnoses. RESULTS: Twenty-seven testes showed complete concordance of cytology and histology, and 13 testes showed a mild degree of discrepancy. A severe degree of discrepancy was seen in 13 testes. In the majority of discrepant cases, FNA biopsy diagnosis was more sensitive in detecting evidence of full or advanced maturation. In one case of discrepancy, the histologic finding was Sertoli cells only, and cytology revealed focal full maturation. In vitro fertilization using sperm from this case was successful. CONCLUSION: FNA biopsy of testes in azoospermia is a fast, reliable and minimally traumatic method. The prospects for utilizing FNA biopsy material in assisted and microassisted fertilization are promising.
Adult↗
Detection of Schistosoma mansoni in bronchoalveolar lavage fluid. A case report.
BACKGROUND: Bronchoalveolar lavage (BAL) is a useful tool in the diagnosis of bacterial, viral, fungal and parasitic pulmonary infections. There have been rare reports of parasitic infestations in bronchoalveolar lavage fluid. This is the first case report on detecting a Schistosoma ova in BAL fluid. CASE: A 40-year-old, Egyptian male presented with a fever and productive cough. He had a right pleural effusion and segmental collapse of the right lower lobe. BAL fluid showed several ova of Schistosoma mansoni and established the diagnosis of schistosomiasis. Abdominal ultrasound revealed mild hepatic cirrhosis. CONCLUSION: Schistosomiasis should be considered in the differential diagnosis of pulmonary problems in patients with disseminated disease in endemic areas.
Adult↗