Cross serological reactions between human and animal schistosomes by the fluorescent antibody technique in some laboratory animals.
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Animals↗
Biomedical subjects
M A Amin
Publications and source records attributed to M A Amin.
Studies on heterologous immunity in schistosomiasis. 3. Further observations on heterologous immunity in mice.
Previous studies on heterologous immunity in mice and rhesus monkeys have shown that immunization with Schistosoma bovis, S. mattheei or S. rodhaini cercariae can limit the severity of infection resulting from subsequent challenge with S. mansoni. The present report describes further evidence of the protection afforded by heterologous immunization. It has been demonstrated that mice immunized with S. mattheei can withstand S. mansoni infections that are lethal to normal mice and that the degree of immunity developed is influenced by the level of maturation and the duration of the initial infection, the size and number of immunizing doses, the route of exposure and the sex of the parasite.
Animals↗
Studies on heterologous immunity in schistosomiasis. 2. Heterologous schistosome immunity in rhesus monkeys.
Previous studies on heterologous immunity in mice have indicated that Schistosoma bovis and S. mattheei could be used to limit the severity of infection resulting from subsequent challenge by S. mansoni. These observations have now been extended to study the immunizing effect in rhesus monkeys of both S. mattheei and S. bovis.The bovine schistosomes were shown to be relatively non-pathogenic in rhesus monkeys. Immunization with 1000-2000 cercariae resulted in a marked reduction in the pathogenic effect of subsequent challenge with S. mansoni. This effect was demonstrated by a decrease in the worm load and tissue egg densities in 10 immunized monkeys as compared with 5 control animals.There was no correlation between fluorescent antibody titres and the intensity of infection or the degree of acquired immunity. There was a cross-reaction between S. mansoni and the bovine schistosomes.It is suggested that natural heterologous immunity (zooprophylaxis) may be of considerable epidemiological importance in determining the severity of schistosomiasis in man.
Animals↗
Studies on heterologous immunity in schistosomiasis. I. Heterologous schistosome immunity in mice.
Epidemiological and experimental studies indicate that heterologous immunity resulting from exposure to bovine and other animal schistosomes might be of some importance in determining the relative severity of schistosome infection in man in different parts of the world. The reduction in the severity of a disease process, resulting from exposure to relatively non-pathogenic infections, has been called "zooprophylaxis".The observations recorded in the present paper on the interaction in mice of Schistosoma bovis, S. mattheei and S. rodhaini with S. mansoni provide further evidence of this phenomenon. The most potent immunizing effect was produced with S. bovis and S. mattheei, which resulted in a reduction in the expected S. mansoni egg load of 74% and 85.7%, respectively.It is suggested that zooprophylaxis may be an important factor in limiting the severity of schistosomiasis in areas of Africa where bovine and other animal schistosomes are prevalent. The relatively more severe nature of the disease in Egypt and Brazil may be in part due to the absence of concomitant transmission of bovine schistosomes.
Animals↗
The effect of low-voltage electric therapy on the healing of resistant skin burns.
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Burns↗
Delay in the diagnosis and prognosis of caecal carcinoma--a study of 20 cases.
BACKGROUND: Caecum is the dilated part of the right colon situated in the right iliac fossa, therefore the etiology of this cancer is similar to those of the rest of the colon. Caecal carcinoma is more common in developed countries but it is not a rare disease in underdeveloped countries. This is more common in high socio-economic people who use less fibrous and purified diet. With improvement in health education and social status of the people of Pakistan, there is an emerging trend of Westernization in our society. This may increase the incidence of cancer in Pakistan. Carcinoma of caecum is curable disease is diagnosed early and treated. If we are aware of the pathogenesis, etiology, clinical presentation and management of the disease, we can offer a lot to these patients by diagnosing the caecal carcinoma at an earlier stage, this was the aim of this study. METHODS: 20 cases (15 males and 5 females) of Carcinoma of Caecum were studied from January 1997 to December 1999. Out of these six patients presented in emergency ward, 2 as acute appendicitis and 4 as intestinal obstruction. After routine non-specific investigations, our specific investigations included USG abdomen, barium contrast studies and colonoscopy, Barium study and USG remained of primary importance. RESULTS: Most of the patients were between age 45-65 years, oldest patient being 80 years old and the youngest was of only 30 years. Most of the patients presented as mass in the right iliac fossa and only some patients as intestinal obstruction. Right hemicolectomy with primary ileo-transverse anastomosis was our standard surgical procedure and was done in about 14 cases. But in some cases ileo-transverse by-pass operation was done as the growth was locally advanced. However, only the omental biopsy was taken in the cases where carcinoma was too advanced. CONCLUSIONS: We think that our sociodemographic factors put a hindrance in detection of this carcinoma at early stages and therefore curative procedures are difficult to bear good results.
Adenocarcinoma↗
Diagnosis of deep vein thrombosis in the leg by using colour coded duplex sonography.
BACKGROUND: Deep Vein Thrombosis (DVT) is regarded rare [not readable: see text] Asia. There is no documentation of the incidence of DVT in Pakistan. Clinical diagnosis of Deep Vein Thrombosis is inaccurate. Venography is the most reliable method of diagnosis, but it has several disadvantages. Many non-invasive diagnostic methods have therefore been developed in the past decade. Of these only duplex sonography has comparable accuracy. METHODS: We studied 100 cases of suspected DVT by using colour coded duplex sonography. We report the results of a prospective study in patients with suspected deep vein thrombosis evaluated by both colour coded Doppler sonography and venography. CONCLUSION: We conclude that colour coded duplex sonography is a highly accurate, simple, non-invasive method for detecting femoropopliteal thrombosis. Additional venography is not necessary. Its value in diagnosing isolated calf vein thrombosis remains to be established.
Blood Flow Velocity↗