Biomedical subjects

M A Andreeva

Publications and source records attributed to M A Andreeva.

3 recordsLinked to original sources

PubMed1997

Isoforms of Serratia marcescens nuclease. The role of Mg2+ in the hydrolysis mechanism.

Structural and functional differences between isoforms Sm1 and Sm2, a lack of influence of free Mg2+ on the isoform structures, formation of DNA-magnesium complex serving with great probability as a real substrate for the nuclease has been summarized on the basis of experimental data. Mg2+ forming a complex with phosphate groups of DNA are supposed to further increase the electrophilicity of the phosphorus atoms besides causing a conformational change of the substrate.

Circular Dichroism↗

PubMed1982

[Ischemic bone necrosis in Itsenko-Cushing disease].

X-ray alterations of the type ischemic osseous necrosis were established in three patients (two females and one male) with Icenko-Cushing disease. In the first case--the haed of femur was unilaterally affected: in the second--bilateral lesions with the same localization; and in the third--a combination of changes in the head of femur and the heads of some metatarsal bones. In all patients, secondary ostheoarthrosis alterations were also observed. The tomographic study enabled the visualization of details, characterizing the stage of the progress of the process. The similarity in the roentgenological images, with a substrate of ischemic osseous necrosis in case of exogenous and endogenous hypercortisolism, provide grounds to admit a similarity in the pathogenesis of those states.

Adult↗

PubMedDate not supplied

[Principles of selection of the method of treating Itsenko-Cushing disease].

Various methods for therapy of Icenko-Cushing's disease: radiotherapeutic, surgical and medicinal were evaluated. A total of 184 patients were treated. The authors have been of opinion that therapeutic methods depended on function of the neuroendocrine system and adrenal cortex, e. g. reserpine used after gamma-therapy alone or in combination with unilateral adrenalectomy increased the efficacy of therapy and reduced the time of remission. Parlodel used alone or in combination with chloditan could be used in therapy of early forms of the disease in young patients. Transsphenoidal adenomectomy and proton beam therapy of the hypophysis were recommended in hypophysial adenomas. Proton beam therapy of the hypophysis was an effective method for therapy of patients with diffuse hyperplasia of the adrenal cortex and could be used in diffuse nodular hyperplasia of the adrenal cortex in combination with unilateral adrenalectomy.

Adolescent↗