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Biomedical subjects

M A Beg

Publications and source records attributed to M A Beg.

8 recordsLinked to original sources
PubMed1979

Renal function during ticrynafen therapy.

526 patients with essential hypertension or congestive cardiac failure were treated with ticrynafen (250--500 mg/day) or hydrochlorothiazide (50--100 mg/day) for 6 weeks to 6 months. There was no appreciable effect on renal function, as measured by changes in blood urea nitrogen and serum creatinine levels. Both drugs exhibited similar antihypertensive activity and ability to control signs and symptoms of congestive cardiac failure. Side effects were mild and reversible. A notable difference is the marked reduction in serum uric acid in patients treated with ticrynafen, unlike the elevated urate levels occurring after treatment with hydrochlorothiazide.

Antihypertensive Agents↗
PubMed1979

A double-blind study of tienilic acid with two year follow-up of patients with mild to moderate essential hypertension.

In a double-blind study, thirty patients having mild to moderate essential hypertension were randomly assigned to a six week regimen of either tienilic acid, hydrochlorothiazide, or placebo. Blood pressure was significantly reduced with tienilic acid and hydrochlorothiazide although more so with tienilic acid. Serum uric acid declined strikingly with tienilic acid and increased significantly with hydrochlorothiazide. Serum potassium declined slightly with tienilic acid but more so with hydrochlorothiazide. Serum creatinine and blood urea nitrogen increased slightly more with tienilic acid than with hydrochlorothiazide. There were no clinical adverse effects to any of the medications during this study. Twenty-four months of continuous administration of tienilic acid revealed maintenance of blood pressure effect, but with slight increases in blood urea nitrogen, serum creatinine and uric acid and slight decreases in serum potassium as compared to six weeks administration. Tienilic acid appears to be a useful new antihypertensive agent. The hypouricaemic effect is profound and strongly suggests the need for continuing evaluation of this compound because of its unique combination of diuretic, antihypertensive and hypouricaemic properties.

Adult↗
PubMed1979

Long-term usage of tienilic acid in essential hypertension.

The purpose of this double-blind study was to compare the effects on blood pressure of tienilic acid and hydrochlorothiazide in patients with essential hypertension. The biochemical effects of tienilic acid in relation to those of hydrochlorothiazide were also determined over a long-term period of therapy. Sixty-six outpatients with mild to moderate essential hypertension were treated for seven months with either 250 mg of tienilic acid or 50 mg of hydrochlorothiazide after a 3 week placebo period. When warranted, dosage was increased to a maximum of 500 mg of tienilic acid and 100 mg of hydrochlorothiazide daily. Results indicate that tienilic acid reduced blood pressure significantly and to the same extent as hydrochlorothiazide. No significant side effects were observed. The effects on potassium, blood urea nitrogen and creatinine were comparable in both groups. However, serum uric acid rose with hydrochlorothiazide but fell with tienilic acid. In view of this effect, tienilic acid may have certain advantages over thiazide therapy in the treatment of hypertension.

Adult↗
PubMed1979

Safety of tienilic acid.

The safety and efficacy of tienilic acid have been evaluated in studies of patients with mild to moderate essential hypertension, salt and water retention states and hyperuricaemia associated with gout. During the course of these studies 675 patients were treated with tienilic acid, 310 were treated with hydrochlorothiazide, 43 were treated with probenecid and 34 were treated with placebo. Overall, adverse reactions characterized as probably drug-related or questinably drug-related were reported in 28% of patients treated with tienilic acid, 24% treated with hydrochlorothiazide, 25% of patients treated with probenecid and 33% treated with placebo. The side effects encountered were mild in severity, reversible and represented extensions of the pharmacological activity of tienilic acid, hydrochlorothiazide and probenecid. These initial studies demonstrate that tienilic acid is safe and effective in the treatment of mild to moderate essential hypertension, salt and water retention states, including oedema associated with congestive cardiac failure or mild to moderate renal dysfunction, and in the management of elevated serum uric acid levels associated with gout.

Clinical Trials as Topic↗
PubMed1976

Anatomical and neurohistological observations on the tongue of 60 mm embryo of opossum, Didetphis marsupialis.

The anatomy, histology and innervation of the tongue of 60 mm embryo of opossum, Didelphis marsupialis have been described. The tongue measures 13 mm in length and 4.5 mm in breadth. The tip of the tongue is somewhat pointed and bordered by soft fringe of simple filiform papillae which are probably tactile in function. The fungiform papillae are small rounded bead-like structures scattered over the dorsum. The circumvallate papillae are three in number and arranged in an inverted V-shape. Taste buds are developed over the dorsum of fungiform papillae. The foliate papillae are concealed. The filiform papillae in various stages of development are seen over the entire dorsum. The circumvallate papillae are not fully developed. Mucous glands and their ducts are well-developed. The innervation of the tongue of 60 mm embryo of opossum is almost similar to that of other mammals. The dorsal side of the tongue is covered with thick squamous epithelium and is innervated by thick nerve fibres. The ventral surface is thin and comparatively poor in nerve supply. The skeletal muscles and connective tissue are richly innervated by thick and thin nerve fibres. A large number of ganglion cells lie singly or in irregular groups in the plexuses of the intermingling nerve fibres. The filiform papillae are heavily innervated by thick nerve fibres. Nerve elements could not be observed in the circumvallate papillae. Fungiform papillae are also provided with fine nerve fibres. A few nerve fibres and nerve bundles are seen in the gullet region.

Animals↗
PubMed1975

Anatomical and neurohistological observations on the tongue of the India goat, Capra aegagrus.

The anatomy and neurohistology of the tongue of the Indian goat, Capra aegagrus, have been described. The apex linguae is notched in the centre. The foramen caecum is found to be absent. The sublingua could not be traced. The filiform papillae are the most common and divided into three types: the simple, giant, and true filiform papillae. The true filiform papillae are the most developed of the three types. The foliate papillae are absent. There are 13--14 circumvallate papillae arranged in two rows in a V-shaped pattern. The fungiform papillae are large and could easily be seen with the naked eye. They are scattered over the entire dorsum, being in abundance at the tip. The tongue of the goat is richly innervated. On the dorsum, the lamina propria is innervated by thick nerve fibres. In the fungiform papillae quite a large number of nerve fibres could be seen. The circumvallate papillae are also abundantly provided with nerves. A few ganglion cells are found below the circumvallate papillae. Thick nerve fibres are seen across the numerous glands and their ducts. Muscle fibres and connective tissue are also richly innervated.

Animals↗