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Biomedical subjects

M A Bernard

Publications and source records attributed to M A Bernard.

30 records · Page 2Linked to original sources
PubMed1993

The health status of African-American elderly.

This article reviews the health status of African-American elderly, based on a computerized search of the medical literature from 1987 to 1991, as well as careful review of the report of the Secretary of Health's Task Force on Black and Minority Health. Black Americans have a higher prevalence of malignancies, diabetes, hypertension, obesity, homicide, and unintentional injury than white Americans. These problems contribute to a high mortality rate in young blacks and a greater prevalence of problems with activities of daily living in elderly blacks. Despite the high disease burden among young blacks, blacks are living progressively longer. As the number of elderly blacks increases, health-care practitioners will need to increase risk factor reduction in young-old blacks. Additionally, there will be a need for increased support of physical functioning in elderly African American.

Black or African American↗
PubMed1992

Morbidity, disability, and health status of black American elderly: a new look at the oldest-old.

There are over 2.5 million black Americans aged 65 and over living in the United States today, including some 258,000 persons aged 85 years and over. The post-World War II baby boom within the US black population should ensure that the numbers of persons aged 65 and over will increase into the 21st Century. If present trends continue, it is projected that the current population of black elders will also age. This means that the numbers of black persons aged 85 and over will also increase. Data from both national surveys and population-based community studies concerning the health and well-being of black elders are now becoming available. This report presents information concerning self-reported health status, chronic disease prevalence, disease-risk-factor prevalence, measures of physical functioning, and nursing home utilization rates for age groups within the black population aged 65 years and over. The availability of such data should lead to the development of targeted interventions designed to lessen impairment and prolong independent living.

Black or African American↗
PubMed1990

Alpha-L-fucosidase isoenzyme pattern in hairy cell leukaemia.

alpha-L-Fucosidase isoenzymes pattern in hairy cell leukaemia (HCL) is characterized by the disappearance of the more acidic form when compared to normal lymphocytes. Our data seem to indicate that this profile could not be related to the T or B phenotype because in normal lymphocytes (mainly T), MO cells possessing T markers, as well as lymphocytes from chronic lymphoid leukaemia (CLL) known to exhibit normal-like B phenotypes two alpha-L-fucosidase forms are identified and especially the more acidic one.

Adult↗
PubMed1989

Alpha-L-fucosidase activity in normal human lymphocytes.

After DEAE-Trisacryl chromatography two forms of alpha-L-fucosidase have been characterized in normal human lymphocytes. These enzymatic forms were different with respect to their optimum pH, kinetic properties and isoelectric behaviour. After neuraminidase treatment two forms are still observed with a neutral shift in pI values. These results suggest that at least two structurally different alpha-L-fucosidase units exist.

Adult↗
PubMed1979

Mushroom poisoning in a dog.

The false morel (Gyromitra esculenta), a mushroom responsible for occasional fatalities in man, caused a fatal hemolytic episode in a ten week old dog. The clinical symptoms observed and the gross and histopathological findings, are discussed.

Animals↗
PubMed1977

Visceral leishmaniasis in a dog: clinical, hematological and pathological observations.

Visceral leishmaniasis was diagnosed in a dog that had been living with his owners in Spain for two years. Clinical diagnosis was somewhat delayed as the disease is largely unknown to Canada and was manifested by a nonresponsive anemia which was not easily explained on peripheral blood evaluation alone, and concomitant interstitial nephritis. On post mortem examination splenomegaly was the main gross pathological finding. Light microscopic examination of bone marrow aspirates and subsequent electron microscopic examination of splenic and hepatic tissues revealed numerous Leishman-Donovan bodies in cells of the reticuloendothelial system. Parasitized reticuloendothelial cells were seen singly or forming granulomata. These latter did not contain giant cells and were confined mainly to the liver and spleen, being sparse and single in the first but extremely numerous and coalescing in the latter. Accumulation of intrafollicular hyaline material was seen in a small number of splenic follicles. Leishman-Donovan bodies on electron microscopic examination had a trilaminar periplast, a large round nucleus with heavy blocks of marginated chromatin and two nucleoli, a short flagellum and a kinetoplast. Lymph nodes and bone marrow had numerous parasitized macrophages but no granulomata. Leishman-Donovan bodies were not detected in the lungs and kidneys both of which exhibited a chronic intersitital reaction. The comparative hematological profile as well as the importance of bone marrow and electron microscopic examinations of the spleen and liver in diagnosis are discussed. The potential public health hazard of leishmaniasis to North America and particularly to Canada is considered.

Animals↗