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Biomedical subjects

M A Carrera

Publications and source records attributed to M A Carrera.

17 recordsLinked to original sources
PubMed1990

[Trophic effect of testosterone on erythropoiesis in the mouse].

Some differences between erythropoietin biogenesis under the action of natural stimuli and that resulting from testosterone administration are commented. Evidences are presented suggesting that androgens, apart from amplifying erythropoietin production, might exert some action on the stroma as specific erythrocytic tissue. This action could be anabolic or trophic and not erythropoietin dependent, at least to some extent, its effect being applied on the quantitative erythropoietic homeostasis.

Animals↗
PubMed1984

Systemic oxygen transport and erythropoiesis in the mouse.

Removal of 15% of blood volume in the mouse increases erythropoiesis by a factor of 2.2 when measured 12 h after bleeding. Exposure of normal mice to 40% reduced barometric pressure for the same period of time increases erythropoiesis only by a factor of 1.6. The response to hypoxia takes place in the presence of a 40% reduction of oxygen consumption and tissue-venous PO2, changes which are concomitant with a 5-fold increase in plasma erythropoietin activity. The larger response in anemic animals on the other hand occurs without any detectable change in these parameters. These results cast serious doubts about the interpretation of the quantitative homeostatic control of erythropoiesis based solely on the action of erythropoietin.

Anemia↗
PubMed1980

Acute hypocalcemia and erythropoiesis in the mouse.

Mice were made acutely hypocalcemic by injection of sodium oxalate. After the transient drop of plasma calcium marked changes in erythroblastic proliferation, number of erythroblasts and 59Fe kinetics were observed. The probable mechanism of this response that may reflect increased erythropoiesis is discussed.

Acute Disease↗
PubMed1977

[Erythropoiesis in the mouse following chronic administration of small doses of busulphan (author's transl)].

After both splenectomized and non-splenectomized mice had received a total amount of five doses of Busulfan at a rate of 0.14 mg/48 h, the recovery of their erythropoietic organs through the addition of 59Fe was investigated, after the cytostatic treatment had been cut off. In the non-splenectomized animals recovery was clear, keeping high 59Fe uptake values, significantly above normal, throughout the 21 days of the experiment. In the splenectomized mice, 59Fe uptake reached a peak of 38 per cent three days after the supply had been cut off, and from then on it descended to subnormal values.

Animals↗
PubMed1976

[Effect of a beta-adrenergic blocking agent on erythropoietin production in the mouse (author's transl)].

The effects of the beta-adrenergic blocking agent (propranolol) on erythropoietin production in carbon monoxide intoxicated mice were studied. The raise in plasma erythropoietin after a 4 hour intoxication with carbon monoxide was 47% less in the propranolol treated group. A decrease of 65% in the endogenous erythropoietic response after 75 minutes of carbon monoxide intoxication was found in policithemic treated mice, as against the untreated ones. The tissue oxygen tension was reduced in the propranolol treated group. No changes was found in the hemoglobin oxygen affinity.

Animals↗
PubMed1975

Carbon monoxide and erythropoietin production in mice.

The effects of hypoxemia caused by hypoxia (H-H) and CO (H-CO) on the production of erythropoietin (ESF) in mice were investigated. When mice breathed for 6 hr mixtures of air containing 0.1% of CO or a mixture of air and nitrogen with a pO2 of 52 mm Hg, the tissue pO2 as measured by the gas pocket technique was 16.9 +/- 1.1 and 17.1 +/- 1.4 (mean +/- S.D.), respectively. Plasma ESF content in H-CO mice, however, was twice higher than in the H-H mice. The greater ESF production in H-CO was associated to a significantly less hyperventilatory response as measured by acid-base balance changes and to a lower O2 consumption and was interpreted as the result of displacement of the OHb curve in opposite directions. The ESF organ appears thus to be sensitive to variations in the amount of O2 delivered to the tissues but independent of the arterial pO2.

Acid-Base Equilibrium↗