Biomedical subjects

M A Comendador

Publications and source records attributed to M A Comendador.

4 recordsLinked to original sources

PubMed1992

Transmission of the hereditary S character in Drosophila simulans: effects of aging and temperature treatments.

The expression of the S character of Drosophila simulans associated to hereditary reovirus DSV is affected by the rearing temperature. The transmission of the S character and the consequences of the length of high temperature (28 degrees C) treatments on that transmission were investigated. Larvae treated at 28 degrees C from eclosion to imaginal emergence produce few S individuals in the offspring. The offspring of larvae treated between the 144th hr of development (middle of the pupal stage) and the imaginal emergence show variable levels of S phenotype expression. These levels appear to be related to the age and phenotype of their mothers. Those facts are discussed under the hypothesis of S character being caused by the hereditary reovirus Drosophila S virus.

Aging↗

PubMed1991

Decreased metabolic rate as an acrolein resistance mechanism in Drosophila melanogaster.

Using several mutant strains of Drosophila melanogaster, with different degrees of spontaneous activity, we have studied whether a decreased metabolic rate, measured by oxygen consumption, might be one of the mechanisms involved in acrolein resistance, such as predicted by Hoffmann and Parsons (1989a, b). The results agree with this prediction.

Acrolein↗

PubMed1991

Acrolein genotoxicity in Drosophila melanogaster. I. Somatic and germinal mutagenesis under proficient repair conditions.

The genotoxicity of acrolein in D. melanogaster was investigated using 2 different SMART assays, the eye spot and wing spot tests, and 2 germinal tests, the sex-linked recessive lethal (SLRLT) and sex chromosome loss (SCLT) tests. For the 2 latter, exposure by feeding as well as injection was used. The results indicate that: (i) acrolein is mutagenic in the SLRLT when injected but not when fed; (ii) the SCLT did not reveal clastogenic effects; (iii) acrolein had genotoxic effects in both SMART assays; (iv) we also had several indications that acrolein is metabolized into a second genotoxic product.

Acrolein↗

PubMed1986

EXPERFARM: a new package in BASIC for teaching genetics.

We have developed two interactive computer programs (together referred to as EXPERFARM), which enable simulation of a great variety of genetic situations. This package is designed for teaching basic genetics as well as quantitative and population genetics. The main advantages of EXPERFARM are its great versatility, as different situations can be simulated by simply changing the inputs, and the small amount of training necessary for the users.

Computer-Assisted Instruction↗