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Biomedical subjects

M A Crum

Publications and source records attributed to M A Crum.

4 recordsLinked to original sources

Predictors of length of stay after coronary stenting.

BACKGROUND: Postprocedure length of stay (LOS) remains an important determinant of medical costs after coronary stenting. Variables that predict LOS in this setting have not been well characterized. METHODS: We evaluated 359 consecutive patients who underwent coronary stenting with antiplatelet therapy. Sequential multiple linear regression (MLR) models were constructed with use of 4 types of variables to predict log-transformed LOS: preprocedure, intraprocedure, and postprocedure factors and adverse outcomes. RESULTS: Preprocedure factors alone explained more than one third of the variability in postprocedure LOS (adjusted R(2) = 0.37). The addition of procedural variables added little to the model (adjusted R(2) = 0.39). Entering nonoutcome postprocedure variables significantly enhanced the predictive capacity of the model, explaining more than half the variability in postprocedure LOS (adjusted R(2) = 0.54). In the final model, addition of outcome variables increased its predictive capacity only slightly (adjusted R(2) = 0.61). In this model, significant preprocedure factors included: myocardial infarction (MI) within 24 hours, MI within 1 to 30 days, women with peripheral vascular disease, intravenous heparin, and chronic atrial fibrillation. High-risk intervention was the only significant intraprocedure variable. Significant postprocedure factors included periprocedure ischemia; cerebrovascular accident or transient ischemic attack; treatment with intravenous heparin or nitroglycerin or intra-aortic balloon pump; and need for blood transfusion. Significant adverse outcomes included contrast nephropathy, gastrointestinal bleeding, arrhythmia, vascular complication, and repeat angiography. CONCLUSION: This prediction model identifies a number of potentially reversible factors responsible for prolonging LOS and may enable the development of more accurate risk-adjusted methods with which to improve or compare care.

Coronary Disease↗

Detection of Chlamydia trachomatis endocervical infections by ligase chain reaction versus ACCESS Chlamydia antigen assay.

Ligase chain reaction (LCR) was compared with ACCESS immunoassay for detection of chlamydial infections in females. Despite efforts to improve ACCESS performance by evaluation of specimens that were in the test performance "grey zone," LCR remained more sensitive and was less expensive to perform. ACCESS had a sensitivity of 83.9%, a specificity of 99.7%, a positive predictive value of 96.3%, and a negative predictive value of 98.5%.

Antigens, Bacterial↗

The hyperactive acoustic reflex. Four case studies.

Four case studies are presented to illustrate that low acoustic reflex thresholds may have value in assessment of central auditory processing disorders. Neurologic, electronystagmographic, EEG, speech pathologic, and/or psychological evaluations suggested CNS impairment. Tests for central auditory processing disturbances were positive. For three subjects, acoustic reflex responses were elicited at unusually low hearing threshold levels. A fourth subject showed lowering of acoustic reflex thresholds following bilateral electroshock treatment. These lowered thresholds were interpreted as hyperactive acoustic reflex responses representing a decreased central inhibition on peripheral auditory function. It is proposed that presence of hyperactive acoustic reflex responses may be associated with a concomitant central auditory processing disorder.

Aged↗

Processing demands during auditory learning under degraded listening conditions.

This investigation employed measures of learning accuracy (performance) and learning ease (attention or psychological effort) to assess processing demands during auditory learning under degraded listening conditions. Learning accuracy was measured with a highly intelligible paired-associate learning task presented to 49 normal-hearing adults under different signal-to-competition ratios and signal presentation levels. Learning ease was assessed by a simultaneously presented probe reaction-time task. Final results indicated that (1) primary signal presentation level exerted no effect either on learning accuracy or ease, and (2) the introduction of competing speech into the listening environment exerted no effect on learning performance, but resulted in a significant increase in learning effort. These findings have important implications for listening conditions in educational settings, hearing aid selection, education of hearing-impaired and learning-disabled children, and future study of attentional demands during auditory processing.

Adult↗