PubMed Health⌕ Search

Biomedical subjects

M A Ephros

Publications and source records attributed to M A Ephros.

4 recordsLinked to original sources

Severe Clostridium difficile-associated colitis in young patients with cystic fibrosis.

We report four patients with cystic fibrosis and fulminant Clostridium difficile-associated colitis: two died, and one required hemicolectomy. Three of four patients carried the N1303K mutation. Severe and fatal C. difficile colitis can occur in cystic fibrosis patients, possibly with a genotype-specific predilection (i.e., N1303K/other). Because cystic fibrosis patients may have a wide spectrum of gastrointestinal symptoms, disease caused by C. difficile must be considered when these patients have acute abdominal pain, diarrhea, or severe leukocytosis.

Child↗

Plasmodium falciparum malaria in an asplenic man.

An asplenic man with no prior exposure to malaria was infected with Plasmodium falciparum on a visit to Kenya. The peripheral blood showed a parasitaemia of 5% and displayed all developmental stages of the parasite, resembling the asplenic simian model of malaria.

Adult↗

Infection with Streptococcus milleri.

Streptococcus milleri is unique among the viridans streptococci because it produces abscesses. Five serious S. milleri infections were seen in our hospital in 1 year. The English literature dealing with S. milleri was reviewed. An infection caused by S. milleri is often associated with a gastro-intestinal source. Thus, the speciation of viridans streptococci from pus or blood cultures is clinically relevant. The identification of S. milleri from blood cultures suggests the possibility of serious purulent infection, the source of which may lie in the gastro-intestinal tract. The resultant clinical approach to S. milleri infection is discussed.

Abscess↗

Syndrome of opsoclonus-myoclonus caused by Coxsackie B3 infection.

Coxsackie B3 was cultured from 2 children who presented within two weeks of each other from the Cape Cod, Massachusetts, area showing opsoclonus and myoclonus. The organism was recovered from the cerebrospinal fluid of 1 patient and from the stools of both. Both children had cerebrospinal fluid pleocytosis and gradual, spontaneous resolution of their symptoms.

Cerebrospinal Fluid↗