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Biomedical subjects

M A Fadeeva

Publications and source records attributed to M A Fadeeva.

At least 19 recordsLinked to original sources
PubMed1990

[Beam radiotherapy of malignant tumors using computer-assisted radiotherapy programs].

The authors give a brief description a ROKUS-M + Altai-MT system, its software ASPECT-1, stages of radiotherapy design and implementation of optimized programs. They gave examples of optimum computerized design of irradiation in tumors of the nasopharynx, breast, female genitals, esophagus, lungs, bladder, and rectum. The paper is illustrated with charts of isodoses and distributions corresponding to optimized programs of irradiation.

Breast Neoplasms↗
PubMed1988

[The TDF (time-dose-fractionation) model in brachytherapy].

A method to determine TDF values by standard tables with account of RBE of low-energy x-radiation and a small area of irradiation fields was proposed. Corresponding formulas confirmed by the authors' clinical data, were developed. The authors outlined ways of using these data for assessment and design of courses of brachytherapy to minimize the risk of development of skin radiation damages.

Brachytherapy↗
PubMed1986

[Application of the DMF model taking into account volume and area of irradiated tissue to the prognosis of radiation complications].

Coefficients Kv and Ks for determination of the influence of a volume and area of irradiated tissues in the assessment of DMF factors were presented. The above coefficients were derived on the basis of calculations and a retrospective analysis of the authors' clinical data on radiation complications in the subcutaneous fatty tissue in teleradiotherapy of malignant tumors. The use of the coefficients will make it possible to predict with greater reliability the probability of radiation complications in designing radiation therapy.

Humans↗
PubMed1983

[Single large-dose preoperative irradiation in breast cancer].

Proceeding from radiobiological data, the TDF concept and a cumulative radiation effect the authors proposed a new variant of preoperative radiotherapy in operable breast cancer patients. Single doses for the breast and axillary-subclavicular zone that were 15 and 12.5 Gy, were determined. Observation over 72 patients showed that single irradiation did not influence the course of operation and the postoperative period. Good functional and short-term results of treatment make it possible to recommend single large fraction preoperative irradiation for trials in special oncological and radiological institutions.

Breast Neoplasms↗
PubMed1983

[A system of automated radiation treatment of malignant tumors using optimal irradiation programs].

The authors sum up their clinical experience in the implementation of optimized irradiation programs for tumors of different sites (the esophagus, lung, female genital organs, ear-nose-throat, rectum and urinary bladder) with the help of the first serial specimen of the system of automated control over irradiation--Altai-MT. The utilization of the system makes it possible to save time and avoid an error in the implementation of complex irradiation programs as well as to lower the exposure of medical personnel to radiation. Tumors with average and low radiosensitivity, biologically highly active and located in the vicinity of organs and tissues with a low limit of tolerance to ionising radiation were used as clinical models. Automated programs of irradiation meet the requirements of the conformity and homogeneity of a dose field within a focus of lesion, gradient conditions on the border with normal tissues, the minimization of radiation exposure in critical organs. The purpose of the automation of gamma-beam therapy of tumors is to unite within the common system automated information topometric units and a gamma-therapeutic computer controlled device.

Computers↗
PubMed1983

[Use of time-dose-fractionation models in planning the radiation treatment of malignant tumors].

New methods of the fractionation of preoperative gamma-beam therapy for breast carcinoma and intracavitary irradiation of cervical cancer patients with 252Cf fast neutron sources have been devised and tested on the basis of the concept of a cumulative radiation effect (CRE) and the system of TDF factors at the Chair of Clinical Radiology, Central Institute for Advanced Medical Training. In the selection of regimens of the fractionation of intracavitary irradiation of cervical cancer with 252Cf fast neutrons using the system of TDF factors one should take into account the RBE of the type of radiation that would be equal to 5 by the criterion of a direct response of a tumor within the range of dose rates between 20-30s Gy/hr. Taking account of a short period of half-life of 252Cf sources fractionation schemes should be corrected from the view-point of the system of TDF factors not less than once in 2-3 mos.

Brachytherapy↗
PubMed1980

[Prognostic factors of the probability of the occurrence of complications in the radiation therapy of malignant neoplasms].

The authors present an analysis of the causes of radiation induced complications in 383 patients referred to the Chair of Clinical Radiology from different medical institutions of the country. It was found that under distant gamma therapy, to prevent the development of complications the value of TDF-factor should not exceed 105--110, for the associated radiotherapy--130--140, and that for close focal roentgenotherapy--130--150. In vast majority of patients (95.3%) the complications resulted from surpassing the normal tissue tolerance. To prevent radiation injuries it is suggested to take into consideration the TDF-factor values, while in planning radiotherapy to choose such schedules of irradiation, which preclude any surpassing of the tolerance of normal tissues and organs adjacent to the tumor.

Humans↗