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Biomedical subjects

M A Feldman

Publications and source records attributed to M A Feldman.

34 records · Page 2Linked to original sources
PubMed1988

Peripheral chemoreceptor control of neurohypophysial blood flow.

Neurohypophysial blood flow responses to hypoxic hypoxia were studied under conditions of vagotomy, carotid sinus denervation, and combined vagotomy and carotid sinus denervation. Arterial O2 tension was lowered from 128 +/- 3 to 31 +/- 1 Torr, whereas pH and arterial CO2 tension remained constant. Denervation of either carotid sinus or aortic arch chemoreceptors alone does not attenuate the dilation of neurohypophysial vessels that accompanies hypoxic hypoxia. Combined denervation, however, completely blocks this response for the neurohypophysis but not for any other brain region studied. Hypoxic hypoxia resulted in an increase in plasma vasopressin (AVP) from approximately 8 to approximately 40 pg/ml. This increase occurred in the intact, vagotomy, and carotid sinus-denervation conditions. This neurosecretory response was also completely inhibited by combined denervation. For most brain regions peripheral chemoreceptors are not involved in the blood flow response; however, the response of the neurohypophysis appears to be mediated via these chemoreceptors, presumably by altering the neuroeffector activity to this region. In addition our data suggest a temporal relationship between neurohypophysial vasodilation and neurosecretion of AVP.

Animals↗
PubMed1987

Influence of chemoreceptors on neurohypophyseal blood flow during hypoxic hypoxia.

Neurohypophyseal blood flow was studied using radiolabelled microspheres in 13 dogs. Hypoxic hypoxia and carbon monoxide hypoxia with similar arterial oxygen contents (CaO2, approximately 8 vol %) were produced. Under conditions of hypoxic hypoxia, 100-200% increases in blood flow in caudate nucleus, white matter, neurohypophysis, and all other brain regions occurred. Similar blood flow responses were observed with carbon monoxide hypoxia in all brain regions except the neurohypophysis. The role of carotid and aortic chemoreceptors in mediating this blood flow response was studied in 6 additional dogs. Similar degrees of hypoxic hypoxia were produced in chemoreceptor-intact and completely denervated animals (CaO2 approximately 8 vol %, PaO2 approximately 33 mm Hg). Hypoxic hypoxia produced a 250% increase in neurohypophyseal blood flow and a concurrent rise in plasma arginine vasopressin from 8 +/- 3 to 52 +/- 8 pg/ml. Chemoreceptor denervation completely inhibited the increase in neurohypophyseal blood flow associated with hypoxic hypoxia. Arginine vasopressin was not increased by hypoxic hypoxia under conditions of complete denervation. A unique role for peripheral chemoreceptors in regulating neurohypophyseal blood flow is postulated.

Animals↗
PubMed1986

Parent education project II. Increasing stimulating interactions of developmentally handicapped mothers.

Two studies are reported on the assessment and training of parent-child interactional skills in developmentally handicapped mothers. Study 1 compared the interactions of eight developmentally handicapped versus eight nonhandicapped mothers during play with their young (6-25 months) children. Results showed that the former group generally interacted much less with their children and that they were less likely to praise appropriate child behavior and imitate child vocalizations. Study 2 attempted to remediate these deficits, using a training package consisting of discussion, modeling, feedback, social reinforcement, and self-recording. Results showed, first, that the training did increase the targeted skills to well within the range found for the nonhandicapped mothers. Second, training effects generalized from the group instructional setting to the mothers' own homes. Third, newly acquired skills were generally maintained at or above levels found for the nonhandicapped mothers over a 5- to 10-month follow-up period. Finally, all seven children showed increases in vocalizations concomitant with parent training. The results suggest that developmentally handicapped mothers can be taught to provide more effective and stimulating interactions to their young children.

Adult↗
PubMed1986

Research on parenting by mentally retarded persons.

This article focuses on research related to the assessment and training of parenting competencies of persons with mental retardation and the status of the children being raised by retarded parents. Previous findings and that of our own investigations suggest that (1) children of mentally retarded parents are at risk for language and cognitive delays, mental retardation, maltreatment, and neglect; (2) child development is highly correlated with the quality of the home environment and mother-child interactions; (3) retarded mothers provide less positive interactions with their children during play than do nonretarded mothers; and (4) retarded mothers can be taught to improve their child-rearing skills.

Child↗
PubMed1985

Parent Education Project. I: Development and nurturance of children of mentally retarded parents.

The development and home environments of 12, 2-year-old children raised by mentally retarded mothers were assessed using the Bayley Scales of Infant Development and the Caldwell Home Observation for Measurement of the Environment (HOME) Inventory. Results indicated that the children were at-risk for developmental delay, particularly in language. The child's cognitive development was significantly correlated with (a) whether the mother had a previous child removed from the home by child protection authorities and (b) HOME Inventory total scores. Analyses of HOME subscales revealed that mothers who were involved, responsive, and restrictive and punishing had children with higher Bayley Mental Development Index scores.

Adult↗
PubMed1983

Isolation of cells secreting specific polypeptides.

Antibody coupled erythrocytes in an agar overlay were used as a simple, nontoxic technique for the isolation of cell clones secreting proteins and hormones in vitro. The adaptation of the reverse hemolytic plaque assay was developed to provide a rapid, sensitive, and specific method for the screening of any antigen secreting cell without the need of prior isolation. This technique promises to be of use in the characterization and cloning of cells growing in mixed culture.

Animals↗
PubMed1982

A new method for recovering latent fingerprints from skin.

The developed method for detecting fingerprints on live human skin involves first fuming the suspected area with iodine, and then placing a 35-mm clear plastic strip with a leuco crystal violet coating and a trace of water over the fumed area. A few seconds later a dark purple reproduction of the ridge pattern develops. It is a stable direct positive and can be mounted in a 35-mm slide mount for direct viewing. Readable prints may be obtained up to 1 h after impression on live human skin and two or three lifts may be obtained from the same print.

Dermatoglyphics↗
PubMedDate not supplied

Effectiveness of home-based early intervention on the language development of children of mothers with mental retardation.

The authors evaluated the effects of a home-based parent training program for mothers with mental retardation on the language development of their children who were at risk for language delay. The participants, 28 mothers labelled mentally retarded with children under 28 months of age, initially showed significantly fewer positive mother-child interactions and child vocalizations and verbalizations than did a comparison group of 38 families with children of similar age whose mothers were not mentally retarded. The 28 mothers with low IQ were then matched on child entry age and randomly assigned to either an interaction training or attention-control group (this group received training in safety and emergency skills unrelated to interactions). Interaction training consisted of verbal instruction, modelling, feedback, and tangible reinforcement. After training, the training group scores were no longer lower than those of the comparison group of mothers without mental retardation and were also significantly higher than the scores of the attention-control group on all maternal positive interactions, child vocalizations, verbalizations, and language and social domains of the Bayley Scales of Infant Development. Speech emerged significantly sooner in the training group as compared to the control group. The training group parents and children maintained improvements up to 82 weeks following training, and the attention-control group, when subsequently trained, replicated the original training group results. Thus, home-based parent training increased positive maternal interactions of mothers with mental retardation, which facilitated language development in their young children.

Child Abuse↗
PubMedDate not supplied

Parenting education for parents with intellectual disabilities: a review of outcome studies.

Parents with intellectual disabilities (i.e., IQ < 80; mental retardation) are overrepresented in child maltreatment cases and have a variety of parenting skill deficits. Their children are at risk for neglect, developmental delay, and behavioral disorders. This review of parenting education interventions for such parents identified 20 published studies with adequate outcome data. A total of 190 such parents (188 mothers, 2 fathers), with IQs ranging from 50 to 79 were involved. Parenting skills trained included basic child-care, safety, nutrition, problem solving, positive parent-child interactions, and child behavior management. The most common instructional approach was behavioral (e.g., task analysis, modeling, feedback, reinforcement). Overall, initial training, follow-up, and social validity results are encouraging. Generalization and child outcome data are weak. Further research is needed to (a) identify variables associated with responsiveness to intervention, and (b) develop and compare innovative programs that teach parents with cognitive disabilities the necessary generalized skills to demonstrate long-term beneficial effects on their children.

Adult↗