Biomedical subjects
Publications and source records attributed to M A Flerov.
The amount of lipid peroxidation products (conjugated dienes and trienes and Schiff bases) in cortical neurons of the cerebral hemispheres decreased by 30% at the peak of convulsions observed 10-15 min after intraperitoneal injection of picrotoxin. In neuroglial cells of control animals the intensity of lipid peroxidation in was 1.7-2.0 times lower. Picrotoxin had no effect on this parameter.
We studied the effect of prenatal stress on protein peroxidation in the plasma of rats during postnatal ontogeny. Oxidative destruction of proteins in prenatally stressed rats differed from that in control animals. These differences were most pronounced in postnatal ontogeny, i.e. during the development and maturation of CNS.
Lipid peroxidation processes were studied in the striatum during stress in conditions of prior administration of cortisol. Three doses of cortisol (25 mg/kg, daily) had no significant effect on the levels of lipid peroxidation products six days after injections ended. However, lipid peroxidation responses to stress during this period in animals given cortisol were significantly stronger than in controls (there were decreases in the intermediate products of lipid peroxidation and increases in the quantities of Schiff bases). Thus, administration of hormone leads to long-term changes in one of the most important regulatory systems of the body--lipid peroxidation--and has sensitizing effects on changes in the levels of stress-induced lipid peroxidation products.
We studied whether intranasal treatment with HSP70 can be used for the correction of maladaptive behavior in rats after unavoidable stress. After 3 intranasal injection of HSP70 in a dose of 3.25 microg we observed normalization of adaptive behavior after unavoidable stress and improvement of physiological reserves of the organism.
Serum protein peroxidation was studied in rats with different strategy of adaptive behavior at rest and during short-term immobilization stress. Oxidative destruction of serum proteins was less intensive in KLA rats compared to that in KHA rats. Stress stimulated peroxidation of serum proteins in KHA rats.
Differences in the intensity of serum protein peroxidation were detected in pregnant rats with high and low peripheral nervous system excitability threshold in stress. Stress induced shifts in serum protein peroxidation, but these changes were opposite in rats of the two studied strains.
Lipid peroxidation in the rat striatum under stress after cortisole injection was investigated. Three days cortisole injections (25 mg/kg every day) do not affect the level of lipid peroxidation products 6 days after termination of the hormone injection. However, in these periods, cortisole injected rats had a more significant response of lipid peroxidation to stress than the control animals (decrease of intermediate products and increase of Shift bases). Thus, the hormone injection induced a long-term changes in so important a regulatory system of the organisms as the lipid peroxidation, causing sensitization of its response to stress.
Cortisol administration for 3 days prior to a 6-day rest decreased formation of lipid peroxides in the rat hippocampus under stress. Exogenous cortisol limits the response of oxygen-reactive species to the lipids and exerts a regulating influence on development of a response to stress.
The study has shown seasonal changes in the responses of the frog bladder isolated preparation to exogenous adrenalin. The finding is explained by heterogeneity of the smooth muscle adrenoreceptors and alteration of functionally domineering populations during the winter-spring cycle. The changes corresponded to modifications of the fraction composition of phospholipids, the modifications being, probably, one of the ways of regulation of the smooth muscle adrenoreceptor apparatus' activity.
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Na+,K(+)-ATPase activity was studied in neurones and neuroglia under conditions of convulsions caused by picrotoxin administration. Picrotoxin is a stimulant which causes convulsions by suppression of presynaptic inhibition. Na+,K(+)-ATPase activity in neuroglia was increased in convulsion, bat was not altered in neurones. It is possible, that glial Na+, K(+)-ATPase activity plays the role of neuronal ion's flows regulator and neuronal protector from convulsions. In recovery period ATPase activities in neuronal and neuroglial cells run up to control.
Heroin addicts at the initial stage of abstinence syndrome were subjected to detoxication by liquorosorption technique. The fractions of their cerebrospinal fluid obtained by the thin layer chromatography technique were analyzed. The substances extracted from the cerebrospinal fluid of drug addicts, presumably peptides, negatively affected the conductive function and synaptic transmission in surviving slices of the olfactory cortex of rats. The conclusion was drawn about a possibility of application of surviving rat brain slices as test object for estimation of the extent of purification of the cerebrospinal fluid from toxic endogenous substances after the liquorosorption.