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Biomedical subjects

M A Fox

Publications and source records attributed to M A Fox.

At least 73 records · Page 4Linked to original sources
PubMed1985

Patency of autogenous saphenous vein versus polytetrafluoroethylene grafts in femoropopliteal bypass for advanced ischemia of the extremity.

Eighty-six femoropopliteal bypass operations were performed for ischemic ulceration, gangrene or rest pain in 77 patients whose mean preoperative ABI was 0.35. In this homogeneous patient sample, we compared prospectively a trial of saphenous vein versus PTFE grafts. During the follow-up period amputations were required in 30 per cent of the patients with a vein graft and in 31 per cent of patients with a PTFE graft. However, the presence of gangrene significantly decreased the interval to first occlusion (p less than 0.001). Over-all, autogenous saphenous vein grafts had longer patency than PTFE grafts in both the femoropopliteal and distal bypass positions. This advantage prevailed when 45 of the patients were randomized, although not at statistically significant levels. In patients without gangrene who underwent limb salvage, bypassing the diseased femoropopliteal segment with either of the graft materials increased graft patency and limb salvage compared with patients who had ischemic tissue necrosis.

Adult↗
PubMed1984

Symptom use and self-regulation in type II diabetes.

A model of self-regulation that explains the health behavior of type II diabetic patients was tested by examining the use of symptoms as indicators of perceived blood glucose levels in 38 outpatients. Results of the study supported the self-regulation model by demonstrating that patients use symptoms to monitor blood glucose levels and to guide diabetes-related actions. Implications of the model for planning interventions with type II diabetes are discussed.

Attitude to Health↗
PubMed1984

Hypothermic cardiopulmonary bypass in a patient with sickle-cell trait.

A male patient, aged 7.5 years, with known sickle cell trait, presented for correction of Fallot's tetralogy. The successful management under hypothermic cardiopulmonary bypass is described and the behaviour of sickle haemoglobin under hypothermic conditions is discussed.

Anemia, Sickle Cell↗
PubMed1980

Endodermal sinus (yolk sac) tumors of the anterior mediastinum.

Seven cases of endodermal sinus tumor (yolk sac tumor) primary in the anterior mediastinum are added to the literature bringing to 21 the number of reported cases. This germ cell tumor should be included in the differential diagnosis of anterior mediastinal tumors. It has occurred in males 13--49 years old who are often systemically ill. Since this tumor almost always produces elevated levels of serum alpha-fetoprotein, a strong presumptive diagnosis is possible prior to biopsy. The prognosis is poor. The two disease-free survivors of the 21 reported cases were both treated with a combination of excision and chemotherapy.

Adult↗
PubMed1978

Treatment of cutaneous Herpesvirus hominis type 2 infection with 8-methoxypsoralen and long-wave ultraviolet light in guinea pigs.

Treatment of cutaneous Herpesvirus hominis type 2 infection in albino guinea pigs with 8-methoxypsoralen plus long-wave ultraviolet light was evaluated by clinical assessment and quantitative viral cultures. There was a statistically significant difference between the treated animals and the controls in relation to vesicular development, rate of healing, and viral titers. The treatment was effective after the appearance of lesions, when viral multiplication has already begun.

Animals↗
PubMed1973

Differentiation of Drosophila cells lacking ribosomal DNA, in vitro.

Drosophila melanogaster embryos that lacked ribosomal DNA were obtained from appropriate crosses. Cells were taken from such embryos before overt differentiation took place and were cultured in vitro. These cells differentiated into neurons and myocytes with the same success as did wild-type controls. Therefore, ribosomal RNA synthesis is not necessary for the differentiation of neurons and myocytes in vitro.

Animals↗
PubMedDate not supplied

The inability of CCK to block (or CCK antagonists to substitute for) the stimulus effects of chlordiazepoxide.

To further examine the relationship between cholecystokinin (CCK) and GABA, the present study assessed the ability of the CCK-A antagonist devazepide and the CCK-B antagonist L-365,260 to substitute for the stimulus effects of chlordiazepoxide (CDP), as well as the ability of CCK-8s to block these effects, in female Long-Evans rats within the conditioned taste aversion baseline of drug discrimination learning. Both devazepide and L-365,260 failed to substitute for the discriminative stimulus properties of CDP, and CCK-8s failed to block its stimulus effects. The benzodiazepine diazepam did substitute for, and the benzodiazepine antagonist flumazenil did block, the stimulus effects of CDP. This suggests that the lack of substitution for, or antagonism of, CDP by the CCK antagonists and CCK-8s, respectively, was not due to the inability of the present design to assess such effects. Possible bases for the current findings, e.g., necessity of an anxiogenic baseline, drug and receptor specificity, as well as the dose-response nature of the interaction, were discussed. Given that a relationship between CCK and GABA has been reported in other designs, the present results suggest that such a relationship may be preparation specific.

Animals↗