[Prenatal diagnosis of anencephalus].
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Biomedical subjects
Publications and source records attributed to M A Fuks.
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A promising method of ultrasonic diagnostics is compound or multiple scanning. Its application in obstetrics makes it possible to more distinctly define the contours of the structures studied. Results subsequent to an examination of 750 pregnant women showed that by using this method it becomes possible to determine the position of the fetus, biparietal diameter of its head, the size of the placenta, abnormalities in the development of the fetus, etc. The advantages of compound scanning are particularly spectacular in estimating the growth of the fetal head during early periods of gestation.
The prenatal diagnosis of mannosidosis was carried out in one at-risk fetus by the analysis of chorionic villi obtained after 9 weeks of pregnancy. The diagnosis was based on the absence of acid alpha-mannosidase activity as determined by specific enzyme assay. The activity of two other lysosomal hydrolases (beta-galactosidase and beta-hexosaminidase) in chorion biopsy specimen was similar to the control values. The enzymatic diagnosis was confirmed after studies of fetal tissue.
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