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Biomedical subjects

M A Hafiz

Publications and source records attributed to M A Hafiz.

At least 19 recordsLinked to original sources
PubMed2002

Anti-HIV activity of a glycoprotein from first trimester placental tissue.

Human Immunodeficiency Virus-1 (HIV-1) transmission from a mother to the offspring during pregnancy is highly complex and a variable process in part due to the presence of several anti-HIV factors. In this study, we report an early pregnancy-associated protein (early pregnancy associated protein-1, Epap-1) with an apparent molecular weight of 90 kDa in placental tissue of pregnant women during the first trimester. Epap-1 was isolated and purified using Sambucus nigra agarose lectin affinity chromatography. Epap-1 strongly inhibits HIV-1(MN), HIV-1(91US056), HIV-1(VB-7) replication in vitro while it exhibits low activity with HIV-1(VB-66) strain. The molecular analysis of action of Epap-1 shows that it affects HIV-CD4 binding through inhibition of CD4-gp120 interaction.

Anti-HIV Agents↗
PubMed1988

Cytomorphologic changes in split-course radiation-treated bronchogenic carcinomas.

The cellular changes produced by radiation therapy were studied in cytologic specimens from seven patients with bronchogenic carcinoma: squamous-cell carcinoma (four patients), adenocarcinoma (two patients), and small-cell undifferentiated carcinoma (one patient). Cytologic samples were obtained from sputum and bronchoscopic examination in patients before and after they received a course of radiation. The cells were studied by light microscopy. An increase in the percentage of columnar cells was detected in five of seven patients independent of the latency of cytologic sampling posttherapy. The percentage of macrophages was unchanged in patients sampled at 15, 18, and 24 mo after the last radiation dose; leukocytes were decreased in relative frequency in the majority of patients studied. Following irradiation, moderately atypical and severely atypical metaplastic cells were increased in relative frequency (48% versus 15% and 19% versus 3%, respectively) and malignant cells were decreased (40% versus 22%) or absent in all patients, irrespective of the type of carcinoma. Nuclear vacuolation, nuclear enlargement, loss of chromatin texture, and rupture of the chromatinic rim were seen in atypical and cancer cells. Infiltration of cancer cells by leukocytes was observed in two of four patients with squamous-cell carcinoma. In all treated patients, morphologic observations indicated that irradiation produces similar damage to "normal" bronchial epithelial cells although such changes are less apparent at longer time intervals following therapy.

Adenocarcinoma↗
PubMed1988

Cytophotometric determination of DNA in mesotheliomas and reactive mesothelial cells.

Cytophotometry was used to study the nuclear DNA content of cells in Feulgen-stained effusion specimens from 18 patients with mesothelioma and 14 patients with reactive mesothelial proliferations. The mean DNA content (MDNA) of mesothelioma cells was significantly higher than that of reactive mesothelial cells (P less than .001). Other parameters reflecting the DNA content also differed significantly between the two kinds of cells, including (1) the ratio of mean mesothelial DNA to mean lymphocyte DNA, (2) the percentage of mesothelial cells with DNA content exceeding three times the lymphocyte MDNA and (3) the coefficient of variation of the DNA content. Since these parameters were highly correlated, only one was accepted in a stepwise linear discriminant model for distinguishing reactive from mesotheliomatous effusions. The model correctly classified all of the reactive effusions studied and 89% of the mesotheliomatous effusions. These results indicate that DNA analysis, using the Feulgen stain and cytophotometry, yields criteria that may be useful in distinguishing benign reactive mesothelial cells from malignant mesothelioma in effusions when used in conjunction with other traditional parameters.

Adult↗
PubMed1986

Hemangioma of the masseter muscle: a case report and review of the literature.

The case of a patient with a hemangioma of the masseter muscle is presented. The treatment in this case was superficial parotidectomy and resection of the hemangioma. A review of the literature reveals that the masseter muscle is a fairly uncommon location for hemangiomas. Among the cases reported the diagnosis was rarely made preoperatively. Most authors recommended that superficial parotidectomy be done as part of the surgical excision.

Adult↗
PubMed1986

Multicentric ovarian and extraovarian cystadenofibroma.

A case of multicentric ovarian and diffuse pelvic cystadenofibroma is described. Despite multicentricity, the histologic findings are completely benign. Electron microscopy was performed and possible mesothelial origin is discussed.

Adenofibroma↗
PubMed1985

Cholesterol granuloma of the petrous apex and sphenoidal sinus: a case report.

A case of a cholesterol granuloma located in the petrous apex and eroding into the sphenoidal sinus is reported. Cholesterol granuloma is thought to occur when pneumatized cells in the temporal bone become obstructed. Although usually occurring in the middle ear, it can occur in the petrous apex. The diagnosis and surgical management are discussed.

Cholesterol↗
PubMed1985

Carcinoma of the uterine cervix resembling lymphoepithelioma.

A case of cervical carcinoma with marked lymphocytic infiltration is described. The tumor is histologically similar to lymphoepithelioma of the nasopharyngeal region or medullary carcinoma of the breast. This tumor may have a favorable prognosis. Only two Japanese groups have reported this tumor as a distinctive entity. One such case is reported herein.

Carcinoma, Squamous Cell↗
PubMed1984

An atypical fibromyxoid tumor of the prostate.

An unusual fibromyxoid tumor of the prostate is described that may be confused with embryonal rhabdomyosarcoma (botryoid sarcoma). The cells were fibroblastic, and the tumor lacked mitotic activity. Rhabdomyoblasts were not seen under either light or electron microscopy. Although the cells presented a strap-like appearance, striations were not observed. Results of immunoperoxidase studies were also negative for muscle origin. The tumor has pursued a benign clinical course.

Fibroma↗
PubMed1983

Adenocarcinoma arising in female urethral diverticulum.

Cancer arising from a female urethral diverticulum is rare, and because of its rarity, a review of the medical literature reveals significant nonuniformity in its management. We report an additional 2 cases of this disease, one of which has an even rarer feature of being mucin-producing. The management of our 2 cases is presented in detail and in line with the management of female urethral cancer. From our extensive literature search, diverticulectomy alone showed poor results with the highest rate of recurrence (67%). Extensive surgery, either in the form of cystourethrectomy or anterior exenteration, offered results comparable with those of combined therapy (diverticulectomy and full course of irradiation for early cases; preoperative irradiation followed by cystourethrectomy for late cases). Individualization of radiation treatment and cooperative effort between urologist and radiation oncologist are essential if best results are to be achieved.

Adenocarcinoma↗
PubMed1982

Congenital hemangioendothelioma of the hand--case report.

This is a case report of a congenital hemangioendothelioma-a rare vascular tumor of the hand. The literature concerning hemangioendothelioma has numerous conflicting statements as to histologic definition, malignant potential, and optimal treatment. A newborn found to have a hemangiomatous type of lesion on the index finger of the right hand was operated upon at 7 days of age. An intraoperative brachial arteriogram identified the radial digital artery as the major arterial supply to the lesion. The operating microscope allowed precise dissection and preservation of the digital nerves and the flexor and extensor tendons. The defect was covered with a full-thickness skin graft providing optimal follow-up for local recurrence.

Female↗
PubMedDate not supplied

Osteoblastoma of the temporal bone: CT findings.

A case of recurrent benign osteoblastoma of the temporal bone is presented with discussion of the clinical, radiological, and pathological findings. Previously reported cases of osteoblastoma of the temporal bone are briefly reviewed.

Adult↗
PubMedDate not supplied

Fine needle aspiration in stromal sarcoma of the breast. Light and electron microscopic findings with histologic correlation.

Stromal sarcoma of the breast, according to current concepts, is a rare lesion arising from the stroma surrounding the ductal epithelium. A case of this neoplasm is reported, with light and electron microscopic findings in fine needle aspirates and correlation with histologic findings. The findings, similar to those previously reported for stromal sarcoma of the breast, included a less-pleomorphic morphologic picture than is seen in malignant fibrous histiocytoma, but a more primitive ultrastructural appearance.

Aged↗
PubMedDate not supplied

Fine needle aspiration biopsy in the evaluation of lymphoma presenting as an ovarian and uterine mass.

Fine needle aspiration (FNA) was performed in conjunction with frozen section on a patient with primary uterine and ovarian lymphoma. While the frozen section showed evidence of tumor, a diagnosis of lymphoma was not possible on the frozen section alone. The fine needle aspirate showed the tumor to be a lymphoma. In cases of suspected lymphoma, FNA in conjunction with frozen section may be helpful for making the definitive diagnosis.

Aged↗