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Biomedical subjects

M A Kahn

Publications and source records attributed to M A Kahn.

8 recordsLinked to original sources
PubMed1992

Demonstration of human papillomavirus DNA in a peripheral ameloblastoma by in situ hybridization.

The peripheral ameloblastoma (PA) is a rare, extraosseous, odontogenic lesion usually located on the mandibular or maxillary gingiva. It often appears as an asymptomatic, firm, pink-red nodule with occasional secondary involvement of the underlying bone. Although histologically identical to primary intraosseous ameloblastoma, the PA is notably less aggressive in biologic behavior and rarely recurs following conservative treatment. It has a proposed dual histogenesis, while its etiology remains obscure. Several benign oral mucosal lesions have been found to be associated with various types of human papillomavirus (HPV). The following study uses a commercially available HPV DNA in situ hybridization technique to confirm the presence of HPV in a previously reported case of PA. Results were positive for HPV types 16/18 but negative for HPV types 6/11. The implications of these results with regard to etiology are discussed.

Adolescent↗
PubMed1992

Mucinous ovarian tumors with pseudomyxoma peritonei: a clinicopathological study.

Eight patients with mucinous ovarian tumors and pseudomyxoma peritonei were matched by their original ovarian tumor histology with eight tumor controls without pseudomyxoma peritonei. In each group, four tumors were benign, three were low malignant potential, and one was malignant. Cases compared with controls more frequently showed cyst rupture (3 vs. 2), periovarian adhesions (5 vs. 4), mucinous lesions of the appendix (4 vs. 0), goblet cells (8 vs. 4), and tumor necrosis (3 vs. 1). All cases displayed pseudomyxoma ovarii, which contained mucinous epithelial cells. Only one control exhibited pseudomyxoma ovarii, but it did not contain epithelial cells. In all cases, the peritoneal mucin contained epithelial cells. Two cases were noteworthy, each of which displayed a change in histology (benign to low malignant potential and benign to malignant) 6 years after the original ovarian tumor operation. One of these cases was not associated with pseudomyxoma peritonei until the first recurrence of the benign ovarian tumor. These data suggest that pseudomyxoma ovarii, with epithelial cells, may presage the development of pseudomyxoma peritonei and/or malignant recurrence.

Appendiceal Neoplasms↗
PubMed1992

Flow cytometer analysis of oral premalignant lesions: a pilot study and review.

In a retrospective study, we examined 34 premalignant lesions of the oral cavity by flow cytometer analysis on formalin-fixed, paraffin-embedded tissue submitted to the University of Tennessee, Memphis, Oral Pathology Laboratory. Three categories of oral epithelial dysplasia were represented (eight mild, seven moderate, nine severe), as well as five epithelial hyperplasias without dysplasia and five fibrous nodules as controls. The DNA index and total proliferative index of each case were calculated. The objective of the study was to determine the amount of epithelial dysplasia necessary in oral lesions before DNA aneuploidy or high proliferative index is detectable and thus determine if flow cytometric analysis can be a diagnostic adjunct for oral premalignant lesions. The results showed that some cases in both the control and dysplastic categories exhibited a high total proliferative index (control = 1, no dysplasia = 1, mild dysplasia = 3, moderate dysplasia = 2, severe dysplasia = 2), whereas only the dysplastic lesions had an abnormal DNA index [8 of 24 (33%)]. The results indicate that flow cytometric analysis may have some limited potential as a diagnostic adjunct in oral premalignant lesions.

Aneuploidy↗
PubMed1991

Regional odontodysplasia. Case report with etiologic and treatment considerations.

Regional odontodysplasia, a relatively rare developmental abnormality of the dental hard tissues, most often unilaterally and segmentally involves the anterior maxillary teeth of young females. Patients often have pulpal pathosis, periodontal manifestations, and irregularities of the eruption sequence of the affected teeth. The resultant reduced density of the enamel and dentin imparts a radiographic appearance of "ghosting" with correspondingly enlarged pulp chambers and canals. Etiology is uncertain; numerous local and systemic factors have been proposed. Treatment may sometimes be controversial, and timing of extractions and restorative procedures is critical. This case report illustrates the signs and symptoms of regional odontodysplasia, to aid clinicians in early recognition of the condition, to provide further evidence that a local circulatory disorder might be involved in its pathogenesis, and to illustrate treatment options that consider the patient's development and welfare.

Child, Preschool↗