Inhibition of adjuvant arthritis by statolon.
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Adjuvants, Immunologic↗
Biomedical subjects
M A Kapusta
Publications and source records attributed to M A Kapusta.
Periostitis: an early diagnostic sign of juvenile rheumatoid arthritis.
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Arthritis, Juvenile↗
Restoration of diminished splenic responses to phytohemagglutinin and concanavalin A in adjuvant-induced disease by corticosteroids: further evidence for the presence and pathogenetic role of two populations of splenic suppressor cells.
This study confirms observations that active adjuvant-induced disease is accompanied by diminished spleen cell responses to phytohemagglutinin and concanavalin A; and that these diminished responses are due to suppressor cells, some adherent only to glass, and others adherent to plastic or glass. Corticosteroid inhibition of adjuvant disease is accompanied by a diminution or absence of these splenic suppressor cells. Some of these suppressor cells are inhibited in vitro by corticosteroids, in preference to the mitogen-responsive cells. This suggests that suppressor cells may play a role in the pathogenesis of AID.
Animals↗
The virus-activated suppressor cell hypothesis in experimental and human rheumatic diseases.
I suggest that many of the features of the autoimmune diseases may be explained by an alteration in the immunoregulatory balance of various T lymphocyte populations by virus-activated suppressor cells. The evidence for this hypothesis is presented and evaluated in adjuvant disease in rats, NZB/W disease in mice, and in human autoimmune diseases.
Animals↗
Wegener's granulomatosis and relapsing polychondritis: a case report.
Relapsing polychondritis, a rare disorder characterized by inflammation of cartilaginous tissue, is often associated with vasculitic features. Wegener's granulomatosis is an uncommon form of vasculitis, usually responsive to treatment with cyclophosphamide. A 59-yr-old man with relapsing polychondritis, initially well controlled by corticosteroid therapy, developed pulmonary infiltrates and glomerulonephritis. After pathological confirmation of Wegener's granulomatosis, cyclophosphamide therapy was instituted and remission achieved.
Cyclophosphamide↗