Biomedical subjects
Publications and source records attributed to M A Kramen.
An embryo was recovered surgically from a naturally ovulating, naturally inseminated Papio cynocephalus female on day 5 of gestation and transferred surgically to a naturally synchronized, nonmated Papio cynocephalus female on 20 March 1975. A male baboon weighing 875 grams was delivered by cesarean section on 5 September 1975, 174 days after estimated ovulation time.
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Preimplantation mouse embryos were incubated for various periods in the (14)C-labeled intermediates of the tricarboxylic acid cycle, malate, citrate, or 2-oxoglutarate. A marked increase in uptake of these substrates first occurred at the 4-cell stage, the uptake increasing with the length of incubation and the developmental stage of the embryo. In the light of recent observations on ultrastructural changes in mouse embryos with development, studies of mitochondrial transport systems, and the growth of metabolic activities in developing mouse embryos, the increase in accumulation of the tricarboxylic acid cycle intermediates with development may indicate fundamental changes in mitochondrial function that is necessary for further development.