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Biomedical subjects

M A Lange

Publications and source records attributed to M A Lange.

9 recordsLinked to original sources
PubMed1987

[Effect of x-irradiation on amoebocytopoiesis in the snail].

The [3H]thymidine radioautography technique was used to study the objective laws of the renewal of blood cells (amoebocytes) of the edible snail (Helix pomatia) after X-radiation. Cells which are the precursors of amoebocytes actively proliferating beyond the limits of peripheral blood have been shown to possess a high radiosensitivity. The action of lethal doses of radiation (200-500 Gr) suppresses their proliferation and leads to the irreversible amoebocytopenia. Radioresistant cells lost the ability to the proliferation circulate in the peripheral blood.

Animals↗
PubMed1979

[Origin of fibroblasts and macrophages of skin wound granulation tissue].

By the method of thymidine autoradiography and fluorescing antibodies, the origin of cells participating in healing the experimentally produced wounds was investigated. 3H-thymidine was administered a day before the production of the wounds. 14C-thymidine was injected impulsively 1 h before the material was fixed 1,3 and 8 days after the trauma. The analysis of the autographs demonstrated that during wound healing the cell-precursors of macrophages and fibroblasts migrate from beyond the limits of the connective tissue. By means of the fluorescing antibodies in mouse radiation xenogenic chimaeras it was demonstrated that macrophages and fibroblasts participating in wound healing take their origin from the donor's elements, that is, are of bone marrow origin.

Animals↗
PubMed1978

[Electron-microscopic and autoradiographic study of giant cells of foreign bodies in the focus of aseptic inflammation].

Ultrastructure of sinuous proximal and straight distal tubules, as well as collecting tubules of the cortical layer in the rat kidney fixed with perfusion has been studied with electron microscopic morphometry 7--8 weeks after contralateral nephrectomy. The volume of mitochondria, the area of their crists, the area of the membranes in intracellular labyrinth and other morphometrical parameters have been calculated. Relative volume of mitochondria in the nephron areas studied does not change, while in the collecting tubules it is elevated. The area of crists in mitochondria and "coefficient of morphological organization level" of these organells in the proximal tubules are increased, in the distal do not change, in the collecting tubules increase again. Subcellular changes described are discussed mainly in terms of enhancement of concentrating function of the compensatory-hypertrophic kidney.

Animals↗