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Biomedical subjects

M A Morris

Publications and source records attributed to M A Morris.

12 recordsLinked to original sources
PubMed1992

Robinow syndrome in two siblings from consanguineous parents.

A Kurdish family had two children affected with Robinow syndrome. The daughter had short stature, macrocephaly, hypertelorism, hepatosplenomegaly, short forearms and marked vertebral anomalies. Her brother had hypertelorism, hypertrophied alveolar ridges, hepatosplenomegaly, short forearms, rib anomaly and ambiguous genitalia. The karyotype of the affected male sibling showed mosaicism for 45X, 46,X,dicY(q11.22), 47,X,dicY(q11.22),dicY(q11.22).

Abnormalities, Multiple↗
PubMed1992

High affinity, Ca2+ specific ATPase and Na+K(+)-ATPase in the gills of a supralittoral crab Leptograpsus variegatus.

1. The gills of Leptograpsus variegatus contain a high-affinity, Ca(2+)-activated ATPase, probably located in the basolateral plasma membrane of the gill epithelia. 2. The affinity of the ATPase for Ca2+ is in the micromolar concentration range (6-35 mumol/l). 3. The specific activity of the enzyme did not change during the moult cycle. The ATPase probably does not contribute substantially to increased calcium influx from the medium during the post moult period. 4. The enzyme is believed to function as a selective extrusion mechanism involved in the maintenance of a low cytosolic Ca2+ level in the epithelial cells.

Animals↗
PubMed1992

Lipids and Dupuytren's disease.

We studied prospectively the relationship between serum lipids and Dupuytren's disease of the hand in 85 patients, 65 men and 20 women. The Dupuytren patients had significantly higher fasting serum cholesterol and triglyceride levels than did the controls (p < 0.001). The raised levels of serum lipids appeared to be associated with the pathogenesis of Dupuytren's disease, and this may help to explain the high incidence of Dupuytren's disease in alcoholic, diabetic and epileptic patients, since these conditions are also associated with raised serum lipid levels.

Adult↗
PubMed1979

Enhanced nonenzymatic glucosylation of human serum albumin in diabetes mellitus.

Use of an ion exchange chromatographic method and a colorimetric method with thiobarbituric acid showed that levels of nonenzymatically glucosylated serum albumin were increased in patients with poorly controlled diabetes mellitus compared to controls. The two methods correlated well (r = 0.99) and clearly discriminated between normal and poorly controlled diabetic populations. The levels of glycosylated hemoglobin were also measured in both populations. Several patients apparently in good control based on glycosylated hemoglobin measurements were found to have increased levels of glycosylated albumin. Because albumin has a shorter circulating half-life than does the human erythrocyte, the plasma concentration of glucosylated albumin should be expected to reflect short-term control of hyperglycemia in diabetes. The studies reported here suggest that the level of glucosylated albumin may indeed be a sensitive indicator of moderate hyperglycemia and of early glucose intolerance.

Blood Glucose↗
PubMed1977

Morton's metatarsalgia.

In a series of 25 patients (predominantly women) with Morton's metatarsalgia, the most likely site for a neuroma is the third cleft of the left foot. If a swelling is present or if radiographic examination shows toe divergence then the diagnosis in unlikely to be a simple digital neuroma. A review of the literature suggests that there are other causes of pain in the forefoot. Usually the pain is diffuse by when it is localized, Morton's metatarsalgia is diagnosed. However, causes other than a digital neuroma, e.g. traumatic bursitis and rheumatoid arthritis, epithelial cyst, and foreign body should be borne in mind.

Adult↗