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Biomedical subjects

M A Ostrovskiĭ

Publications and source records attributed to M A Ostrovskiĭ.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Comparative study of lipid peroxidation in the eye pigment epithelium of pigmented and albino animals].

The induction of lipid peroxidation in the eye pigment epithelium of pigmented rabbits by the Fe2+ + ascorbate and xanthine--xanthine oxidase systems did not result in accumulation of malonic dialdehyde. In albino rabbits the lipid peroxidation of the non-pigmented pigment epithelium and retina occurred at a high rate under the same conditions. The rate of lipid peroxidation also showed an increase after removal of melanoprotein granules from the pigmented pigment epithelium. The latter inhibited the rate of lipid peroxidation in the eye retina. In albino animals the rate of lipid peroxidation in a mixture of the tow tissues (i.e. pigment epithelium and retina) is almost 4 times that in the pigmented animals. Consequently, the pigmented pigment epithelium of the eye is much more resistant to the effect of prooxidant systems as compared to the non-pigmented one. It is assumed that one of the main functions of the melanoprotein granules in the eye pigment epithelium cells is their protective effect.

Albinism↗
PubMed1980

[Inhibition of lipid peroxidation by melanoprotein granules].

The effects of melanoprotein granules of the eye pigment epithelium and synthetic melanin on lipid peroxidation in rat liver microsomes and azolectin liposomes were studied. It was shown that lipid peroxidation in the microsomes and liposomes induced by ascorbate or the Fe2+ + ascorbate system is effectively inhibited by the melanoprotein granules and synthetic melanin. The enzymatic lipid peroxidation in the microsomes induced by NADPH and NADPH + Fe2+ is insensitive to the effect of the melanoprotein granules, but is inhibited by synthetic melanin. It is assumed that melanin is mainly responsible for the inhibitory action of the melanoprotein granules.

Animals↗
PubMed1978

[ATP regeneration in the outer segments of frog photoreceptors].

The outer segments of retinal photoreceptors of the frog Rana temporaria were found to possess the adenylate kinase and creatine phosphokinase activities. It was shown that the activities found are not due to contaminations by the fragments of inner photoreceptor segments and pigment epithelium processes which are in direct contact with outer segments. The absolute value of the ATP resynthesis rate exceeds the rate of its hydrolysis. It is concluded that ATP synthesis in the creatine phosphokinase and adenylate kinase reactions is one of the pathways of ATP regeneration in vivo.

Adenosine Triphosphatases↗