A rotation in population-based health for internal medicine residents.
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Biomedical subjects
Publications and source records attributed to M A Patmas.
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Erythema chronicum migrans and acrodermatitis chronica atrophicans are both recognized to be lesions associated with Lyme disease, although they are thought to be distinct entities. In this paper, the clear evolution of erythema chronicum migrans into acrodermatitis chronica atrophicans is demonstrated.
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The author reports a case of eosinophilia-myalgia syndrome (EMS), not associated with the use of tryptophan. Other nutritional supplements should be considered as possible etiologic agents in EMS. Further research in this area is needed.
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been implicated as a cause of acute liver failure, acute renal failure, and acute autoimmune hemolytic anemia. Since NSAIDs are capable of causing serious injury to multiple organ systems, it is surprising that no one has observed multisystem involvement in any of the described patients. We describe two patients with multisystem involvement presumed to be secondary to NSAIDs. Both patients had renal failure consistent with acute tubular necrosis. Both patients had liver failure, one with hepatocellular disease and the other with a cholestatic picture. One patient had a Coombs'-positive hemolytic anemia.