Hepatitis B virus transmission by blood donation negative for hepatitis B surface antigen, antibody to HBsAg, antibody to hepatitis B core antigen and HBV DNA.
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Adult↗
Biomedical subjects
M A Peterkin
Publications and source records attributed to M A Peterkin.
Positive direct antiglobulin test due to antiphospholipid antibodies in normal healthy blood donors.
OBJECTIVES: Positive direct antiglobulin tests (DAT) occur occasionally, without obvious cause, among normal blood donors. This is sometimes associated with a false-positive serologic test for syphilis. Positive DATs due to antiphospholipid antibodies (APAbs) are well documented in the antiphospholipid syndrome with systemic lupus erythematosus and the primary antiphospholipid syndrome. METHODS: Using conventional haematologic and serologic methods, we tested 474,545 normal blood donors in the west of Scotland during the years 1991 through 1993. RESULTS: We identified 42 normal blood donors with a positive DAT and observed three who had positive DATs and false-positive VDRL tests, all of whom expressed raised APAbs. CONCLUSION: APAbs may be an incidental cause of positive DATs among healthy blood donors.
Antibodies, Antiphospholipid↗
The therapeutic value of HPA-1a-negative platelet transfusion in post-transfusion purpura complicated by life-threatening haemorrhage.
Post-transfusion purpura (PTP) was diagnosed in a female patient 1 week after transfusion for hysterectomy. Despite treatment with oral steroids and intravenous immunoglobulin, platelet counts remained low, and the patient developed profuse rectal bleeding. Random platelet transfusion is reported to be ineffective in PTP. We report a case in which the transfusion of HPA-la negative platelets provided good increment and clinical haemostasis before intravenous immunoglobulin could have had an effect.
Antigens, Human Platelet↗