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Biomedical subjects

M A Pilot

Publications and source records attributed to M A Pilot.

26 records · Page 2Linked to original sources
PubMed1986

Comparison of the side effects and gastrointestinal motility observed after administration of erythromycin and josamycin to dogs.

The effects of intravenous erythromycin and josamycin on gastrointestinal motility in dogs have been compared. Erythromycin interrupted the basal motility pattern in the fasted state and induced irregular bursts of spikes in both the fasted and fed states. Emesis occurred in all the dogs in the fasted state experiments and in four out of six dogs in the fed state experiments. Josamycin did not disturb gastrointestinal motility and no dog showed signs of discomfort. The difference in the chemical structure of erythromycin and josamycin is the main reason for their differential effect on the gastrointestinal tract.

Animals↗
PubMed1985

Organization of fasting and postprandial myoelectric activity in stomach and duodenum of conscious dogs.

In conscious dogs, contractile and myoelectric activity was recorded from force transducers and monopolar electrodes chronically implanted in the serosal surface of the proximal and distal stomach. Periodic activity during fasting was characterized at each site. Proximally, activity fronts consisted of a series of regular large-amplitude contractions, without correlated myoelectric changes, occurring at 50-s intervals. The distal activity front comprised a series of bursts of two to three contractions 11 s apart, with each burst in phase with a proximal contraction. Only during the burst sequence was each electrical slow wave associated with a spike burst (1:1 phase locking). In contrast, 1:1 phase locking characterized the electrical correlates of the duodenal activity front. Oral feeding abolished periodic activity for at least 3 h. Postprandially, the proximal stomach remained electrically silent; in the duodenum spike bursts were intermittently associated with regular slow waves, but in the distal stomach regular low-amplitude contractions were characterized electrically by 1:1 phase-locked spike bursts and slow waves. These observations suggest that the proximal stomach regulates the canine fasting activity front and require modification of the concept that 1:1 phase locking is a necessary condition of the activity front.

Action Potentials↗
PubMed1979

Acid secretion from the completely isolated blood perfused canine stomach.

1. The canine gastric arterial supply was isolated and perfused by means of an extracorporeal circuit. The gastric venous blood was returned to the dog's venous system. Histamine acid phosphate (20 microgram min-1) infused intra-arterially gave a mean peak acid output of 2.3 m-mole per 10 min. 2. When a plateau of acid secretion was observed, the gastric venous blood was diverted to the oxygenator, by-passing the dog entirely (vascular isolation). This resulted in an immediate decrease in acid output which fell to or near zero by 90 min after isolation. 3. In three dogs, part of a lung was perfused in series with the stomach before total isolation of the gastric vasculature. With histamine stimulation, acid secretion was observed for about 1 hr with a peak acid output of 0.5 m-mole per 10 min during the period of total isolation. 4. Indomethacin (10 mg kg-1) was given to five dogs approximately 1 hr before vascular isolation. After acid secretion reached a plateau (mean peak acid output 2.3 m-mole per 10 minutes), the gastric circulation was isolated by diverting the gastric venous blood to the oxygenator. Acid secretion was maintained for 50 min, after which it gradually declined to reach 30% of the peak value after 2 hr. 5. Indomethacin (10 mg kg-1) and methysergide bimaleate (1 mg) were given I.V. to five dogs approximately 1 hr before vascular isolation. After acid secretion reached a plateau (peak output 3.0 m-mole per 10 min), the gastric circulation was isolated by diverting the gastric venous blood to the oxygenator. The plateau of secretion was maintained for a further 2 hr with no inhibition. 6. Methysergide bimaleate given alone did not prevent the inhibition of secretion caused by the total vascular isolation of the stomach. 7. These results suggest that in the isolated canine stomach preparation naturally occurring inhibitors of gastric acid secretion, which are normally metabolized at least in part in the lungs, accumulate in the circulation and may account for the observed suppression of acid secretion.

Animals↗