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Biomedical subjects

M A Popova

Publications and source records attributed to M A Popova.

8 recordsLinked to original sources
PubMed1981

[Bioelectrical activity of the brain, cerebral circulation, and heart rate regulation in the early period of isolated cranio-cerebral injuries].

Combined clinico-physiological examination (electroencephalographic, rheoencephalographic and cardiointervalographic) of 48 victims with early-stage isolated craniocerebral injuries were carried out. From the results of the examination it was concluded that the most marked changes of the brain bioelectric activity in that period were associated with the diminution of the cerebral circulation. The higher frequencies of the EEG oscillations were found to be due to an increase of the sympathoadrenal system activity. The decrease of the sympathoadrenal activity and the diminution of the cerebral circulation intensity observed on the second-fourth day after the injury can be explained as being due to an increase of the permeability of the cerebral vessels and development of brain tissue edema.

Adolescent↗
PubMedDate not supplied

Changes in phagocyte activity in patients with ischaemic stroke.

The activity of peripheral phagocytes to generate reactive oxygen species (ROS) was studied in healthy individuals and patients with ischaemic stroke. The aim was to clarify the relationship between phagocyte activity, the time elapsed after the onset of disease and stroke severity. The total and extracellular production of ROS were evaluated by luminol chemiluminescence. Simultaneously the plasma oxidant activity was determined. When stimulated by opsonized zymosan, phagocytes in patients with stroke (regardless of its severity) showed fast activation. The total ROS generation increased over time in all stroke cases studied. However, the extracellular ROS generation was found to be greater in patients with severe stroke than in those with mild neurological deficiency. When stimulated by formyl-methionyl-leucyl-phenylalanine, the total oxidative phagocyte capacity (regardless of stroke severity) increased over time, but there was no change in the amount of extracellularly generated ROS. In patients with stroke the oxidant activity of plasma was enhanced. We conclude that circulating phagocytes in patients with ischaemic stroke are primed for enhanced ROS production by opsonin receptor-mediated stimulation and for increased secretion of myeloperoxidase by opsonin receptor-independent stimulation. The enhanced extracellular generation of ROS through opsonin receptor-dependent stimulation may be considered an oxidative stress biomarker in cerebral ischaemia.

Aged↗
PubMedDate not supplied

[Thermophilic aerobic and facultatively anaerobic bacteria as causative agents of acidification of crab preserves].

The authors studied the influence of regimen of canned crab sterilization on the viability of thermophilic aerobic and facultatively anaerobic bacteria in the product. It has been established that sterilization of canned crabs reduces contamination of the product with thermostable bacteria, although it does not ensure their complete death. During storage at a temperature of 8-10 degrees C thermophilic bacteria lose their capacity for acidification. The product can turn sour in the presence of these bacteria among the residual flora only during storage at higher temperatures.

Acids↗