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Biomedical subjects

M A Razzak

Publications and source records attributed to M A Razzak.

At least 19 recordsLinked to original sources
PubMed1980

Sensitivity of radionuclide brain imaging and computerized transaxial tomography in detecting subdural hematoma.

In a series of 23 patients with surgically proven subdural hematoma of durations ranging between two days to seven months, the detection rate of Tc-99m-pertechnetate brain imaging was higher than computerized transaxial tomography (CT). With dynamic perfusion scanning, the detection rate was 71.5%. However, when combined with sequential static images obtained at 10 minutes, 2 hours and 3--4 hours, the detection rate rose to 92% regardless of the duration of the disease. In contrast, CT demonstrated the hematoma in 52% of the cases. In another 28% the diagnosis was suggested through nonconclusive evidence or presence of contralateral shift of midline structures. Lastly, the result of CT scanning was dependent on the size of the subdural hematoma as evaluated at the time of operation.

Adult↗
PubMed1978

Thallium-201 myocardial perfusion scintigrams in the evaluation of aorto-coronary saphenous bypass surgery.

The effect of aorto-coronary bypass graft surgery (CBG) upon regional myocardial perfusion (RMP) was studied in 23 patients using thallium-201 myocardial perfusing imaging after exercise. We compared the changes in RMP with the clinical status and ECG's during graded treadmill exercise (GTX) before and after CBG. After CBG, the New York Heart Association's "functional class" improved from 3.2 +/- 0.1 (mean +/- SE) to 1.2 +/- 0.2, p less than 0.005. The GTX performance of the patients was also significantly improved postoperatively as judged by the total exercise time (11.7 +/- 0.6 min postop, compared with 7.2 +/- 0.5 min preop; p less than 0.005). Postoperative improved Tl-201 scintigrams were observed in 19 patients, but in only nine patients did the perfusion distribution return to normal. Thus, Tl-201 exercise scintigrams following CBG demonstrate improved RMP in most patients. Failure of regional myocardial perfusion to improve postoperatively, however, does not preclude marked alleviation of angina and improved exercise tolerance.

Adult↗
PubMed1976

Analysis of radiohippuran renogram by subtraction of extrarenal radioactivity.

A method is presented for the simple, non-computerized analysis of the radiohippuran renogram by subtraction of the extrarenal radioactivity as monitored simultaneously by a detector centered over the manubrium sterni. This method requires the application of a calibration factor, relating the level of radioactivity recorded by the sternal detector to that over each kidney area at the end point of the phase of initial rise on each side separately. The results in 15 normal individuals showed a narrow range of values, indicating a high degree of resolution. Verification of the basis of this method of analysis was obtained by accounting for all of the counting rate as extrarenal sources in the tracings of nephrectomized subjects. A further advantage is that the tracing recorded by the sternal detector may be used to calculate renal blood flow.

Adult↗
PubMed1976

Radionuclide scanning of the spleen. Technical modification, normal variants and dimensions.

In order to cut down the time needed for the preparation of the thermally damaged erythrocytes, the effect of heat was combined with the use of a higher concentration of ACD. Heating of the 51Cr tagged red cells was performed in a water bath, at 50 degrees C for 15 minutes, in the presence of ACD in the ratio of one ml ACD for every 3 ml blood. Using this technique, the obtained splenic scans in 20 normal individuals were excellent in quality. In the posterior view, the spleen was oval with an oblique long axis in 65% of the cases and transverse long axis in another 15%. In the remaining 20% the spleen was globular. The average measurements of the spleen were 10.5 X 7,1 cm, with a circumference of 29.8 cm. By planimetry, the surface area of the spleen averaged (59 +/- 12.4) cm2 (Mean +/- 1 S.D.) In the lateral projection, the surface area of the splenic scan was larger by an average of 40% than the picture obtained through the posterior approach in all the six examined subjects.

Adolescent↗
PubMed1976

Splenic radionuclide scanning and sequestration of thermally altered erythrocytes in hepatosplenic sch istosomiasis.

Using heat-treated 51Cr tagged red cells radionuclide scanning of the spleen was performed in 17 patients suffering from hepatosplenic schistosomiasis. Furthermore, following the injection of the thermally damaged erythrocytes, the disappearance half time of radioactivity was calculated from splenic radioactivity build-up tracings. Out of the 17 bilharzial patients examined, 12 had disappearance half times shorter than the lowest limit obtained in normal subjects, denoting exaggerated splenic trapping of heat-treated red cells. Analysis of the results showed that the rate of trapping of heated erythrocytes was more rapid in patients presenting with bigger splenic enlargement, as well as in those having more marked anemia. This might be taken to indicate a possible link between the occurrence of anemia and the spleen in schistosomiasis. By radionuclide scanning, the bilharzial spleen was bigger than normal. In addition, the splenic shadow appeared to be either oval, triangular or kidney shaped. In 9 patients, the distribution of radioactivity was homogenous, with decrease in the density towards the periphery. In the remaining 8 cases, patchy distribution of radioactivity was observed. Mottling was more marked in the huge spleens as well as in the presence of severe anemia.

Adolescent↗