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Biomedical subjects

M A Redding

Publications and source records attributed to M A Redding.

5 recordsLinked to original sources
PubMed1980

Controlled comparison of anew antihistamine-decongestant combination to its individual components.

A new antihistamine-decongestant combination tablet, containing azatadine maleate and pseudoephedrine sulfate, was compared to its individual ingredients and also to placebo, in a double-blind, randomized parallel-group clinical study. Two patient groups were treated, one with seasonal allergic rhinitis for two days during the peak of the ragweed season, and another with perennial allergic rhinitis for an extended six-week period. In both groups the combination was found better than its single components, and all three treatments better than placebo, in relieving the symptoms of allergic rhinitis. A few patients reported a transient drowsiness attributable to azatadine.

Cyproheptadine↗
PubMed1980

Combined vs. single-entity pharmacologic inhibition of induced asthma.

The capacity of single oral doses of theophylline, ephedrine and hydroxyzine, alone and in combination, to prevent antigen-induced changes in airways dynamics was compared in patients with seasonal asthma. Each of the individual components was significantly more effective than placebo. Combinations of theophylline-ephedrine and theophylline-ephedrine-hydroxyzine exerted a significantly greater protective effect than the other treatments. Treatment with theophylline-ephedrine-hydroxyzine was associated with fewer side effects than any other treatment, except hydroxyzine alone.

Adult↗
PubMed1978

Inhibition of cutaneous and mucosal allergy with phenyltoloxamine.

A dose-and-time related-effect of oral phenyltoloxamine citrate, a Class I, H1 antihistamine compound, has been demonstrated against allergen-induced wheal-and-erythema skin reactions among 10 adults with a diagnosis of allergic rhinitis and seasonal pollinosis. Clinical improvement in the existing symptoms of rhinorrhea, nasal obstruction, pruritus and sneezing, showed a significant correlation with the inhibition of reagin-mediated skin reactivity caused by phenytoloxamine. No adverse side effects were observed. It can be concluded that oral phenyltoloxamine citrate possesses antihistaminic properties and a range of safety which make it a useful agent for the symptomatic management of upper respiratory allergy.

Adolescent↗