[Current news in the prevention and treatment of atherosclerosis].
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Biomedical subjects
Publications and source records attributed to M A Samsonov.
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93 patients with rheumatoid arthritis (RA) were given diet therapy and unloading diets (ULD). Adjuvant diets appeared beneficial for RA patients, allowed reduction in antirheumatic drug dosages. ULD are recommended as an alternative treatment of RA dependent on the process activity and pattern.
A controlled trial of 68 patients with rheumatoid arthritis on the medicinal efficacy of a dietetic therapy was made. The employment of a special diet favourably influenced the course of the disease and enabled the dosage of antirheumatic drugs to be reduced, thereby reducing the frequency of side-effects of the drugs.
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The analysis of clinical pattern, psychovegetative disturbances and metabolic defects in coronary patients with a history of myocardial infarction at young age provided information for recognition of two subgroups: normal-weight and overweight patients. Metabolic derangement manifesting with high total cholesterol and triglycerides levels occurred in group II whereas dystonia was registered in both groups as shown by assessment of reactivity and vegetative tone. Background parasympathetic activation and sympathoadrenal activation in exercise grew. Overweight patients seemed to have a marked vegetative dysfunction. The two patterns established have both theoretical and practical significance in terms of design of therapeutical measures.
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A study of 56 males, aged 22 to 56 years, with uncomplicated essential hypertension, stages IB-IIA, where pretreatment examination was followed by repeat investigation after 4 or 5 weeks of treatment with diuretics or low-sodium diets with strict (less than 2 g), moderate (up to 3 g), or mild (4-4.5 g) restriction of sodium uptake, demonstrated a tendency to sodium retention with fluid redistribution from the interstitium to intravascular space in the presence of diuretic treatment. Where dietary sodium was reduced, extracellular sodium was increased owing to increased residual sodium, while total metabolic sodium dropped, and extracellular fluid increased owing to the increase in interstitial fluid. All three variants of the low-sodium diet produced changes in sodium metabolism, with a drop in systemic residual sodium and arterial blood pressure. It is proposed to use strict limitation of dietary sodium for a limited period of time, to be followed by a transition to mildly limited sodium uptake after arterial BP is brought down and stabilized.
Study of the influence of a long-term staged use of diet therapy during prophylactic medical observation of post-myocardial infarction patients has shown that the anti-sclerosis diet used under clinical conditions was effective for relieving the angina pectoris syndrome and obtaining favourable dynamic changes in a number of metabolic parameters. Among the out-patients the diet was used by only 76 per cent. A comparative study of the results of diet therapy during the 3-year medical observation has shown a clear tendency to a gradual reduction of hyperlipoproteinemia and excessive body weight in patients who adhered to the diet. The parameters under study in the group of patients who violated the diet returned to the original level. The incidence of recurrent myocardial infarctions in patients on a diet was twice as low as in those who violated it. Prolonged diet therapy considerably improved parameters of IHD patients' working capacity. A special model has been elaborated for adequate use of the nutritional factor at all stages of the rehabilitation program.
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Influence of differentiated use of the alimentary factors on the lipemia level, hemocoagulation activity, arterial pressure level, carbohydrate tolerance and catecholamine content in the blood plasma of CHD patients was shown under the conditions of controlled dietotherapy. Incorporation of diet in multimodality therapy and prevention of this disease under inpatient, sanatorium-prophylactic and outpatient conditions was emphasized.
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