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Biomedical subjects

M A Sauri

Publications and source records attributed to M A Sauri.

6 recordsLinked to original sources
PubMed1991

The staging and monitoring by primary care providers of patients with human immunodeficiency virus infections.

As HIV testing expands through the population, primary care physicians will become more involved in the testing process. They will also be caring for increasingly larger numbers of HIV infected people from the asymptomatic through those with AIDS, through hospice care, should that become appropriate. This article summarizes key areas of clinician support for the HIV infected, clinical and laboratory markers associated with rapid progression of the disease, and important problem areas in clinical management. It also presents a series of staging diagrams that have proven useful in assisting clinicians in educating patients about the natural history of the HIV infection, the rationale for staging, the rationale for the timing of AZT therapy and Pneumocystis prophylactic treatment, and the significance of various prognosticators in management as the disease progresses.

Biomarkers↗
PubMed1991

Disseminated histoplasmosis in AIDS patients in Maryland.

These patients demonstrate the difficulty in arriving at the diagnosis of disseminated histoplasmosis. The diagnosis in two of the three patients also served as the initial AIDS case-defining opportunistic infection. In each of these patients, the clinical presentations were atypical and in only one patient was a positive exposure history elicited. Recurrent bowel obstruction was the presenting complaint in the first patient and the diagnosis was made only on pathologic exam of the resected small bowel. The second patient's diagnosis was made on biopsy of the colon via colonoscopy. The third patient's diagnosis also eluded an extensive FUO workup; he was diagnosed by bone marrow culture and silver stain of a mediastinal lymph node biopsy, despite serial negative serologic tests for histoplasmosis. The first two patients had significant gastrointestinal disease which is a relatively unusual manifestation for disseminated histoplasmosis. The third patient illustrates the limited diagnostic usefulness of serologic testing in AIDS patients and the continued usefulness of bone marrow analysis in an FUO evaluation. In conclusion, these case presentations demonstrate that disseminated histoplasmosis in patients with HIV infection can present with unusual manifestations, outside of the typical endemic arca, without a positive exposure history or positive serologic test, and may be the initial AIDS case-defining opportunistic infection in these patients. Consequently, a disseminated histoplasmosis should be considered in all AIDS patients with perplexing clinical presentations.

Acquired Immunodeficiency Syndrome↗