PubMed Health⌕ Search

Biomedical subjects

M A Scheinberg

Publications and source records attributed to M A Scheinberg.

At least 37 records · Page 2Linked to original sources
PubMed1986

The effect of isoxicam on neutrophil and monocyte function.

1 Isoxicam was found to inhibit monocyte and neutrophil cell chemotaxis at therapeutic concentrations. 2 The effect was observed after in vitro incubation of normal cells and in vivo in patients with rheumatoid arthritis. 3 Compared to other NSAIDs studied in our laboratory, isoxicam was shown to have a broader spectrum of inhibitory action on the cells involved in the chronic inflammation associated with rheumatoid arthritis.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1986

Chemical classification of hereditary amyloidosis in Brazilian families and identification of gene carriers.

Plasma prealbumin was isolated from individuals in 3 kindreds from Brazil with biopsy proven heredofamilial amyloidosis as well as from a number of asymptomatic family members. The prealbumin samples were cleaved with cyanogen bromide and the resulting peptide mixtures separated by reverse phase high performance liquid chromatography. The peptide elution pattern seen for the individuals with confirmed amyloidosis is consistent for the presence of a prealbumin variant with a methionine for valine at position 30 of the molecule. Sequence analysis of the isolated peptides confirms this observation and shows that the 3 Brazilian families investigated in our study have the same prealbumin variant as individuals with amyloidosis of Swedish/American, Portuguese and Japanese origins.

Adult↗
PubMed1985

Monocyte and lymphocyte interaction in patients with advanced cancer. Evidence for deficient IL-1 production.

Patients with advanced neoplasms have a variety of immunologic abnormalities, including the impaired responsiveness of peripheral blood lymphocytes to mitogen and alloantigen. In the current study it was observed that cancer patients have increased monocyte suppressor cell activity that is mediated by prostaglandins and contributes to the depressed proliferative response of the patients' T-cells. This monocyte suppression, however, is not the major cause of the depressed proliferative response. The study also demonstrated that levels of interleukin 1 (IL-1) produced by lypopolysacharide-activated monocytes from cancer patients are significantly lower than they are in normal subjects.

Adolescent↗
PubMed1985

The effect of piroxicam and auranofin on cell migration.

Previous work at our laboratory has shown that Piroxicam is a potent inhibitor of neutrophil cell migration "in vitro". We have now extended these observations by comparing the effect of Piroxicam "in vivo" on neutrophil and monocyte chemotactic activity as well as comparing the findings with those obtained with Auranofin, a novel oral gold salt preparation. The data presented support the notion that Piroxicam appears to be an inhibitor of neutrophil cell function while Auranofin predominantly affects monocyte cell migration.

Adult↗
PubMed1984

T-lymphocyte subsets in the aqueous humor and peripheral blood of patients with acute untreated uveitis.

We evaluated T-lymphocyte subsets in 18 patients with active untreated uveitis and in 20 controls by monoclonal OKT (Ortho-Kung-T cell) antibodies. Both OKT4- and OKT8-positive cells were detected in the aqueous humor of patients with uveitis. The percentage of OKT4-positive cells (21.1 +/- 7.4) was larger than that of OKT8-positive cells (15.2 +/- 5.3) and the OKT4-OKT8 ratio was 1.40 +/- 0.3. A comparison of aqueous humor and peripheral blood cells from patients with uveitis showed diminished frequencies of OKT4- and OKT8-positive cells. The OKT4-OKT8 ratios were not significantly different. A comparison of peripheral blood cells from patients with uveitis and from controls showed that patients with uveitis had lower OKT4-OKT8 ratios. Lower percentages of OKT4-positive cells were also observed in the peripheral blood cells of patients with uveitis.

Acute Disease↗
PubMed1984

DMSO and colchicine therapy in amyloid disease.

There is no specific therapy for primary amyloidosis, and acquired generalised amyloidosis can be treated only if the underlying disease is eliminated. In this study we have investigated the role of colchicine therapy in primary amyloidosis, and dimethylsulphoxide (DMSO) in leprosy associated secondary amyloidosis. No effect on creatinine clearance or 24 h proteinuria could be observed in the patients with primary amyloidosis. In the DMSO group renal function was considerably improved in 3 patients with moderate renal failure but not in those with severe renal impairment (creatinine clearance less than 10 ml/min). Serum SAA determinations were not particularly informative. These findings point to a beneficial effect of DMSO in human secondary amyloidosis when given at an early stage of renal involvement.

Amyloidosis↗
PubMed1983

The pathogenesis of rheumatoid arthritis and the immune response.

The interrelationship among lymphocytes, macrophages, and neutrophils appears to be an important aspect of the synovial inflammation that is characteristic of rheumatoid arthritis. In a study comparing gold sodium aurothiomalate (GST) with auranofin (Au), an orally absorbed compound, both appeared to inhibit the disease process and no difference between parenteral and oral administration was observed. Another study involved two groups of nine patients with severe rheumatoid arthritis. One group underwent plasmapheresis. The second group underwent total lymphoid irradiation. Both agents appeared to inhibit the disease process. Plasmapheresis was better tolerated that irradiation.

Arthritis, Rheumatoid↗
PubMed1983

The effect of piroxicam on neutrophil and monocyte-macrophage function.

The effect of piroxicam on neutrophil and monocyte chemotaxis was evaluated in vitro and in vivo. Piroxicam demonstrated a marked inhibitory activity on neutrophil chemotaxis and to a lesser extent on monocyte chemotaxis. The data here presented supports the notion that piroxicam interfere with the inflammatory process by affecting primarily neutrophil and to a lesser degree monocyte function.

Anti-Inflammatory Agents↗
PubMed1980

Serum amyloid protein levels in south american children with rheumatoid arthritis: a co-operative study.

Serum amyloid protein (SAA) levels were determined by radioimmunoassay in 90 children with juvenile rheumatoid arthritis (JRA). Significantly higher levels of SAA were present in children with the polyarticular and systemic forms of the disease. SAA levels correlate with disease activity, increasing during acute exacerbations, decreasing during remission and in patients having prednisone therapy. High serum SAA concentrations in children with JRA did not correlate with the presence of secondary amyloidosis and may be useful as a disease monitor.

Amyloid↗
PubMed1980

Peripheral blood monocyte function in leprosy patients.

The activities of monocytes from lepromatous (LL) and tuberculoid (TT) leprosy patients were studied in a variety of in vitro systems. In assays of receptor activity, increased densities of Fc and C3b receptor sites were observed in monocytes of LL and TT patients as compared to normals. No differences were observed between the polar forms of the disease. Similar results were obtained in the nitroblue tetrazolium (NBT) reduction test. Glucosamine incorporation by monocytes from LL and TT patients was not significantly different from that by monocytes from normal controls. A diminished monocyte spontaneous migration and chemotactic activity to lymphocyte derived chemotactic factor (LDCF) was found in both forms of the disease. Plasma inhibitory factor of monocyte chemotaxis was more evident in the lepromatous form of the disease.

Adolescent↗