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Biomedical subjects

M A Selim

Publications and source records attributed to M A Selim.

At least 19 recordsLinked to original sources
PubMed1998

Long-term outcomes of therapeutic pelvic lymphadenectomy for stage I endometrial adenocarcinoma.

OBJECTIVE: The treatment of patients with stage I endometrial adenocarcinoma is often shorter and less expensive if total abdominal hysterectomy (TAH), bilateral salpingo-oophorectomy (BSO), and therapeutic lymphadenectomy are used rather than TAH, BSO, pelvic lymph node sampling, and pelvic external beam radiation. We studied whether the survival and morbidity of patients treated with therapeutic lymphadenectomy are equal to or better than with these alternative treatments. METHODS: We reviewed the medical records of patients with stage I endometrial adenocarcinoma who were enrolled in the MetroHealth Medical Center tumor registry between 1970 and 1993 after undergoing full pelvic lymph node dissection, in addition to total abdominal hysterectomy, bilateral salpingo-oophorectomy, and vaginal brachytherapy. The mean number of resected nodes was 33 (median, 31; interquartile range, 19). Patients were followed for 1. 6-20 years (median, 8 years; interquartile range, 5.8 years). Morbidity and survival rates were compared to published series using similar treatment strategies and to those from studies using pelvic external beam radiation and pelvic lymph node sampling rather than lymphadenectomy. RESULTS: Of 192 patients with pathologic stage I (FIGO 1988) endometrial adenocarcinoma, 178 patients had full pelvic lymph node dissection; 159 patients were evaluable. The 15-year overall survival was 98%; 10- and 15- year disease-free survivals were 96 and 94%, respectively. Overall morbidity was 18% (29/159), and moderate-to-severe morbidity was 13% (21/159). Recurrences were seen in 4.4% (7/159) of patients. Grade and myometrial invasion were not significant predictors of disease-free survival after full pelvic lymph node dissection (grade, P = 0.42; stage, P = 0.67). The results compare favorably with those of similar studies and with studies of pelvic external beam radiation. CONCLUSIONS: Primary surgical management with total abdominal hysterectomy, bilateral salpingo-oophorectomy, therapeutic pelvic lymphadenectomy, and vaginal brachytherapy is a viable and possibly preferable option for patients with stage I endometrial adenocarcinoma.

Adenocarcinoma↗
PubMed1996

Serological diagnosis of extraintestinal Sarcocystosis.

The present study was carried out on eighty patients attending Zagazig University Hospitals. Forty cases suffered idiopathic cardiac diseases (28 with cardiomyopathy, 8 with myocarditis & 4 with valvular lesions) and forty cases suffered idiopathic rheumatic diseases (30 with musculoskeletal complaints and 10 with myositis). Sera were investigated by enzyme-linked immunosorbent assay (ELISA) and indirect fluorescent antibody technique (IFAT) using Sarcocystis fusiformis antigen in order to detect the role of Sarcocystis in initiation of these diseases. Twenty positive toxoplasmic sera and sera from twenty normal individuals were considered as control group. The sera of the investigated cases were tested against Toxoplasma gondii antigen to exclude it as one of the causative agents of these idiopathic lesions. No statistical difference was found between IFAT and ELISA in diagnosis of sarcocystosis (P < 0.05). Also, there was no cross reaction between Sarcocystis and Toxoplasma. This study showed that Sarcocystis can be considered as one of the possible causes of some idiopathic diseases.

Animals↗
PubMed1996

P 53 suppressor gene and cathepsin D expression in correlation with cellular and humoral immunity in cutaneous leishmaniasis.

A total of fifteen clinically and parasitologically proven adult cases of cutaneous leishmaniasis were studied for the demonstration of premalignant factor(s). The levels of antibodies against Leishmania parasite were measured with the indirect haemagglutination test (IHAT) and evaluated with the results of lymphoblast transformation test (LTT), a tumour suppressor gene (P53) and an asportic proteinase enzyme (Cathepsin D). Three patients (females) refused to be biopsied. The results showed a direct correlation between elevation of IHAT in 7/12 patients (Titers 1/128 to 1/512) and elevation of LTT in 7/12 patients (82 to 90%). On the other hand, two males with low (?) seropositive IHAT (1/64) and low LTT (20 & 40%) gave positive P53 antibody and moderate (1) and marked (1) degrees Cathepsin D. So, it is concluded that cutaneous leishmaniasis infection particularly chronic one favours the premalignant changes in the granulomatous lesions.

Animals↗
PubMed1993

Endometrial adenocarcinoma arising in a secretory endometrium.

Endometrial adenocarcinoma in young women below the age of 45 years and in a functioning endometrium is rare. We present the case of a 41-year-old woman, who without clinical risk factors, was found to have a focal well-differentiated endometrial adenocarcinoma in the background of a histologically secretory endometrium. Endometrial evaluation for abnormal vaginal bleeding in a young ovulating female and thorough examination of the endometrium in its entirety in the hysterectomized uterus are reemphasized.

Adenocarcinoma↗
PubMed1988

Determination of the elastic properties of the cervix.

The elastance of the uterine cervix of nonpregnant women was measured by placing a 3- or 4-cm compliant balloon in the cervical canal and determining its pressure-volume characteristic while filling with up to 5 mL of sterile water at a rate of 12 mL/minute. The mean elastance for 247 patients who had previously suffered either one or more spontaneous midterm pregnancy losses, preterm birth, or three or more early spontaneous abortions was significantly lower than that of 42 controls who did not meet these criteria. Elastances were significantly lower in groups having a clinically observed patulous cervix or laceration, or a clinically diagnosed incompetent cervix, than in the normal cervix group. No significant difference was found between the follicular and luteal phases for 64 regularly cycling women. Values were significantly reduced in women showing a widened cervix on a hysterosalpingogram when compared with those with a normal-appearing cervix. When larger Hegar dilators were passed without resistance, the elastance was generally lower, although there was not always good correlation between the largest dilator passed and elastance.

Catheterization↗
PubMed1986

Primary carcinoma of the fallopian tube in an adolescent.

Only three cases of adenocarcinoma of the fallopian tube in an adolescent have been reported previously in the literature, and we report the fourth such case. The main presenting symptom in those patients was lower abdominal pain. Type of therapy and outcome of these four cases is reviewed. The small number of patients precludes definitive conclusion on optimal therapy. For this reason, we urge continued reporting of cases to insure the formation of concrete therapeutic recommendations.

Adult↗
PubMed1986

Improvement of the Botstein-Zacharopolous radiation applicator.

The Botstein-Zacharopolous afterloading radiation source has been modified to facilitate its application to patients receiving intracavitary irradiation therapy. A new clamp assembly, in which each ovoid and the tandum can be separately controlled, has been designed and implemented. A study of 74 patients who alternately received the original or the modified applicator showed the time of the application procedure to be significantly less (p less than 0.001) with the modified device than it was with the original instrument. Fewer X rays were required for evaluating the placement of the modified instrument than the original applicator (p = .055).

Brachytherapy↗
PubMed1985

Cisplatin ototoxicity in gynecologic cancer patients. A preliminary report.

The ototoxicity associated with long-term cisplatin therapy in gynecologic cancer patients was investigated. Twenty-three of 31 patients developed hearing loss and 21 patients reported the onset of tinnitus. The hearing loss was bilateral, cochlear, and permanent. The tinnitus was transient and not predictive of change in hearing level. The likelihood of developing hearing loss appeared to be greatest in patients older than 40 years and in patients with preexisting hearing loss. The amount of change did not appear to be related to the degree of preexisting hearing loss.

Adult↗
PubMed1984

Parametrial needle biopsy: follow-up of pelvic malignancies.

A total of 95 patients had 150 parametrial biopsies with all patients receiving follow-up for a period of 2-10 yr. The analysis of these patients revealed that needle biopsy was successful in differentiating between recurrent, persistent, and/or radiation changes in 97% of the patients. The biopsy was helpful in planning definitive treatment and follow-up in 93% of the patients with minimal complications. This study suggests that parametrial needle biopsy is very useful for diagnosis of persistent and/or recurrent carcinoma of the pelvis and carries minimal complications.

Adenocarcinoma↗
PubMed1980

Cryosurgery for intraepithelial neoplasia of the cervix.

Cryosurgery was used as the means of therapy in 203 patients with intraepithelial neoplasia of the cervix. One hundred and ten patients were diagnosed by colposcopy, directed biopsy, and endocervical curettings. The histological diagnosis varied between mild dysplasia and carcinoma in situ. Carbon dioxide gas was used as the refrigerant. Cryosurgery was effective in 96% of the 203 patients treated. The main causes of failure were: lack of colposcopy, endocervical involvement, the size of the lesion, single freeze, and severity of the lesion. False-negative Pap smear rates were 12.8%. The results suggest that carefully selected patients with early intraepithelial neoplasia can be treated adequately by cryosurgery with low incidence of recurrence and without risk and the cost of hospitalization. Meanwhile, this study reaffirms the need to perform biopsies and investigate any abnormal changes of the cervix, even in the absence of an abnormal cytology smear, before any treatment.

Adolescent↗
PubMed1979

Verrucous carcinoma of the vulva.

A case of invasive verrucous carcinoma of the vulva is reported. The English literature is reviewed and the mode of therapy discussed.

Aged↗
PubMed1979

Modified Marshall, Marchetti and Krantz operation.

A modification of the Marshall, Marchetti and Krantz procedure is described that uses the Babcock clamp for exposure and the rectus muscle for suspension in order to reduce the complications and technical difficulties. The procedure was utilized for 30 patients, and in the same period 27 patients were treated with the nonmodified procedure. A follow-up from one to six years resulted in one patient with a complete failure and another with a partial failure in the modified group and five patients with complete failure in the nonmodified group. The complications rates were essentially the same. However, in the nonmodified group there was one patient with osteitis pubis, one patient with urethral stenosis and two patients with prolonged urinary retention. The results suggest that the modified technique is simple and successful in correcting stress urinary incontinence in women if coupled with adequate study of the patient and careful selection of the treatment.

Adult↗