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Biomedical subjects

M A Serafini

Publications and source records attributed to M A Serafini.

6 recordsLinked to original sources
PubMed1996

Prospective assessment of pregnancy outcomes after first-trimester exposure to fluconazole.

OBJECTIVE: Our purpose was to study prospectively the pregnancy outcome after first-trimester exposure to fluconazole, an effective antifungal agent teratogenic in animals. STUDY DESIGN: We conducted a prospective cohort study of women who contacted three Italian teratogen information services. We compared the pregnancy outcomes of 226 women exposed to fluconazole with that of 452 women exposed to nonteratogenic agents, with use of logistic regression to control for potential confounders. RESULTS: Among the 226 pregnancies exposed to fluconazole there were 22 miscarriages, 1 stillbirth, and 7 infants with congenital anomalies. The prevalence of these outcomes and of neonatal growth parameters and the rate of neonatal complications were similar to those in the reference group. Women in the fluconazole group had a fivefold increased occurrence of induced abortions. CONCLUSIONS: First-trimester exposure to fluconazole does not appear to increase the prevalence of miscarriages, congenital anomalies, and low birth weight.

Adult↗
PubMed1994

[Injuries in pregnancy].

From a review of the literature on this subject it emerges that around 6-7% of women are injured during the course of pregnancy. Road accidents, falls and domestic accidents are the most frequent events: it is therefore important to provide pregnant women with information to prevent such events which may endanger both maternal and fetal health.

Accidental Falls↗
PubMedDate not supplied

[The psychological aspects of pregnancy].

Pregnancy is a stage of maturation crisis which, like other moments of crisis in a woman's life (adolescence and menopause), is characterised by phases of regression, the weakness of mental defences and transformation of the image of self. When there are conflicts with femininity, the experience of pregnancy may be complicated and unease may be expressed in somatic symptoms such as nausea and vomit, and may even lead to the onset of pathologies such as hypertension, miscarriage and pre-term labour. This has led to the term "psychological" risk pregnancy being used over the past 20 years.

Female↗