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Biomedical subjects

M A Sobrinho-Simões

Publications and source records attributed to M A Sobrinho-Simões.

At least 19 recordsLinked to original sources
PubMed1985

Prognosis in colorectal carcinoma. A reassessment of the pathologist's role.

The prognostic significance of some pathologic features was evaluated in a series of 177 patients with colorectal carcinoma consecutively treated by curative resection in a department of Surgery from 1960 to 1981. There were 90 men and 87 women with a mean age of 59.2 +/- 12.8 and a range from 23 to 88 years. Current follow-up information was obtained in 92.7% of the patients. Pathologic staging as classified according to a modification of Dukes' original scheme was found to be the most important prognostic factor. Evaluation of lymphatic and venous invasion, histologic differentiation, and site of tumors also provided valuable prognostic information. Size, configuration, mucin-producing ability and the morphologic evaluation of the so-called "host immunologic response" were found to be irrelevant for the prognosis when the influence of the other indices was controlled.

Adult↗
PubMed1985

Prognostic significance of some pathologic factors in breast carcinoma.

The prognostic significance of several pathologic factors was analysed in a series of 221 cases of breast carcinoma consecutively and primarily treated in a department of surgery. It was found that the outcome of patients could be fairly well outlined in routine practice using the axillary nodal involvement (absence or presence of metastases and number of "positive" nodes), tumor size as measured in surgical specimens and histopathologic evaluation. It was also found that the predictive value of tumor grading is clearly enhanced when it is used in combination with the histological classification. The histological pattern and sinus histiocytosis of regional lymph nodes, as well as the lymphoid infiltration of the tumors, were also found to have some prognostic importance. The presence of vascular invasion in primary tumors of patients with nodal metastases as well as the finding of extranodal extension did not provides additional prognostic information.

Adult↗
PubMed1985

Hürthle-cell lesions of the thyroid: a combined study using transmission electron microscopy, scanning electron microscopy, and immunocytochemistry.

Hürthle cell transformation found in 2 nodular goiters, 2 cases of Hashimoto's thyroiditis, 4 follicular adenomas, 3 follicular carcinomas, 2 papillary carcinomas and 1 anaplastic carcinoma were studied by transmission electron microscopy, scanning electron microscopy and immunocytochemistry. Ultrastructural features of Hürthle cells were identical in non-neoplastic and neoplastic lesions. Cells crammed with mitochondria, showing abnormalities in size, shape and content were prominent in most cases. The presence of distinct smooth-surfaced cells interspersed with cells with many microvilli is almost a pathognomonic scanning electron microscopic feature of benign and malignant Hürthle cell lesions. Most Hürthle cells stained positively for thyroglobulin in all cases, but no immunoreactivity for CEA and calcitonin was found.

Adenocarcinoma↗
PubMed1985

Hürthle cell and mitochondrion-rich papillary carcinomas of the thyroid gland: an ultrastructural and immunocytochemical study.

Of 52 consecutive papillary carcinomas of the thyroid, the following cases were included in this study: one Hürthle cell papillary carcinoma, one papillary carcinoma with foci of Hürthle cells, and 10 cases of papillary carcinoma with abundant mitochondria (volumetric density of mitochondria greater than or equal to 20%). All cases were studied by light microscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and immunocytochemistry. Our results showed that papillary carcinomas mainly or exclusively composed of Hürthle cells are very rare; that Hürthle cell papillary carcinomas of the thyroid share the biologic characteristics and blend insidiously with the so-called mitochondrion-rich papillary carcinomas; that TEM and SEM can provide useful evidence for achieving the differential diagnosis between Hürthle cell and so-called mitochondrion-rich papillary carcinomas; and that immunocytochemical studies are useless in the aforementioned differential diagnosis.

Aged↗
PubMed1983

High relative frequency of thyroid papillary carcinoma in northern Portugal.

Two hundred and twelve papillary and 40 follicular carcinomas were found in 3002 thyroid glands examined from 1931 to 1975 in four Laboratories of Pathology that fairly cover northern Portugal. There was a striking preponderance of women both in papillary (female:male = 6.9:1) and follicular carcinoma (5.7:1). Sex-specific frequency of malignancy was significantly greater in men (13.3%) than in women (8.8%). The overall papillary/follicular ratio was 5.3:1 and did not significantly change throughout the study period. Papillary/follicular ratio was not significantly greater in litoral (5.5:1) than in regions with a low iodine intake and a relatively high prevalence of goiter (3.5:1). It is advanced that this high relative frequency of papillary carcinoma in northern Portugal, even in goiter areas, may reflect the existence of a racial factor since there is not enough evidence to support the influence of dietary iodine, previous irradiation and concurrent thyroiditis.

Adenocarcinoma↗
PubMed1981

Mediastinal and hilar fibrosis.

A case is described of mediastinal and hilar fibrosis in a woman aged 22 years. The fibrotic mass compressed the lobar arteries as well as the veins of various lobes of both lungs. These large vessels as well as numerous smaller arteries and veins were to a large extent obstructed by organized thrombi. It seems likely that 3 years after the beginning of symptoms the fibrosing process was still active. The case provides some support for an immunopathological aetiology of this condition.

Adult↗
PubMed1980

Comparative morphometric study of cerebellar neurons. I. Granule cells.

Several differences concerning granule cell characteristics have been reported in phylogenetic studies. In this work, the granule cell features of 4 frogs, 4 pigeons, 4 rats, 4 cats and 6 human subjects were determined using morphometric methods. Frog granule cells showed a significantly greater volume and a significantly lower numerical density in comparison with the other species; nevertheless no significant differences were found concerning their organelles. The volume of granule cells was significantly smaller in man than in the other two mammal species but no significant differences were observed in their numerical densities. A significant negative correlation was found between the mean cellular volume and the numerical density of granule cells in every species. These results support the assumption that the biological development of the human cerebellar granular layer is accompanied by a miniaturization of the granule cells, in a way similar to that previously suggested for cerebral neurons.

Adolescent↗
PubMed1980

Comparative morphometric study of cerebellar neurons. II. Purkinje cells.

The morphometric characteristics of Purkinje cell perikarya and dendritic trees were evaluated in 4 men, 4 cats and 4 rats. Purkinje cell perikaryon size, as well as the number of synapses and the synaptic surface per Purkinje cell, are significantly greater in man than in the cat and the rat. No significant differences were found as concerns the volumetric densities of nuclei and nucleoli. It is advanced that the higher number of synaptic afferences per Purkinje cell in man may represent the morphological counterpart for the increased resolution of the human mossy fiber-granule cell afferent system.

Adolescent↗
PubMed1978

Relative high frequency of childhood Hodgkin's disease in the north of Portugal.

Sex, age and histopathologic pattern of 322 cases of Hodgkin's disease diagnosed at the Laboratory of Pathology of Oporto Medical School between 1930 and 1974 are presented. 35 (10.9%) of the 322 patients were less than 10 years old. The male/female ratio of childhood Hodgkin's disease was 2.9:1 and the histologic observation revealed mixed cellularity in 18 (51.4%) and nodular sclerosis in 10 (28.6%) of the 35 cases. Childhood Hodgkin's disease relative frequency has abruptly decreased in the last five years of the study period. Most of the children belonged to large families living under poor socioeconomic conditions and the majority of them presented in advanced clinical stages. These findings are similar to those previously described in some developing countries of tropical and subtropical regions and reinforce the advanced relationship between under-development and the geographic variations in childhood Hodgkin's disease frequency and pattern.

Adolescent↗
PubMed1978

A comparative morphometric study of synaptic vesicles and other organelles in mossy fiber endings of the pigeon and the rat.

The mossy fiber ending organelles of 4 rats and 4 pigeons were studied using ultrastructural morphometric methods. The number of agranular vesicles per square micrometer of synaptic surface, as well as the number of agranular vesicles per synapse, were found to be greater in the rat than in the pigeon, while no significant differences were found in coated and dense core vesicles. A highly positive correlation was found, in both species, between the synaptic surface and the number of agranular vesicles per unit volume of mossy fiber endings, while no correlation was found between the synaptic surface and numerical densities of coated and dense core vesicles.

Animals↗
PubMed1978

Nucleolar abnormalities in human papillary thyroid carcinomas.

The nuclei of 17 occult and common papillary thyroid carcinomas were studied with an electron microscope. In most of the nuclei, numerous clusters of large interchromatin granules were seen. Nucleoli with a microfibrillar cortex and segregation of their components were observed in some tumors. Dense RNA containing microspherules were found in altered nucleoli and in complex nuclear bodies. These ultrastructural features seem to reinforce the advanced involvement of a disturbed RNA metabolism in human papillary thyroid carcinomas.

Carcinoma, Papillary↗