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Biomedical subjects

M A Stenchever

Publications and source records attributed to M A Stenchever.

At least 55 records · Page 3Linked to original sources
PubMed1978

Promethazine hydrochloride: use in patients with Rh isoimmunization.

Twenty-two babies born to 21 mothers were treated prenatally for varying periods of time with promethazine hydrochloride in doses of 150 mg. per day. Seven of the 22 babies required intrauterine transfusions. With the exception of positive clinical impressions in some cases, specific ameliorating effects of the drug in this group could not be demonstrated.

Blood Transfusion, Intrauterine↗
PubMed1978

Genital herpes and the FTA-ABS.

The fluorescent treponemal antibody-absorption test (FTA-ABS) was obtained on a series of 55 healthy men and women with documented recurrent genital herpes. In contrast to a previous report indicating that a significant number of these patients demonstrated a false positive FTA-ABS, the present series failed to confirm these findings. Of interest, however, was the high incidence of borderline FTA-ABS tests seen in both the control group and the group with herpes. The significance and use of the FTA-ABS are briefly discussed.

False Positive Reactions↗
PubMed1977

Combined therapy for endometrial carcinoma preoperative intracavitary irradiation followed promptly by hysterectomy.

A group of 99 patients with endometrial cancer clinically confined to the uterus has been treated with preoperative adjunctive intracavitary irradiation followed within 72 hours by total abdominal hysterectomy and bilateral salpingoophorectomy. Those patients with poorly differentiated tumors, deep myometrial invasion, cervical involvement, or pelvic metastasis were then considered for external beam radiotherapy to the whole pelvis because of the increased risk of involvement of pelvic nodes or other pelvic structures. Only one of 16 patients so treated has failed in the pelvis. The overall Berkson-Gage actuarial survival at 3 years, uncorrected for death from intercurrent disease, is 85.8%. No vaginal recurrences have been identified. Although this series has not been randomized, it appears that there has been a reduction in vaginal and pelvic recurrences when compared with patients reported by others who have received no adjuvant radiotherapy. The low recurrent rate and favorable survival in this group of patients was achieved with low morbidity from this treatment technique.

Castration↗
PubMed1977

The results of a five-year study of continuous fetal monitoring on an obstetric service.

A 5-year experience of the effects of fetal monitoring at the University of Utah College of Medicine (1971-1975) are reported. During this period there were 5087 deliveries, of which 4237 (83%) were monitored electronically during labor. During this time the primary cesarean section rate increased from 3.19% in the year before monitoring has begun to 10.5% in the last year of the period studied. This increase, however, was due primarily to a number of changes in obstetric practice and to an increase in the number of high-risk patients followed at our institution. The rate of primary cesarean section as compared to total deliveries due to fetal distress resulting from observations made with electronic monitoring was a fairly stable 3-3.5%. The number of cases of Apgar scores at 1 minute of 6 or less dropped markedly during the period of study and cases of 5-minute Apgar scores of 6 or less decreased slightly. The number of patients demonstrating early, late, and variable deceleration patterns remained fairly stable throughout the years of the study. Variable and late deceleration patterns correlated well with cord compression and small placentas, respectively.

Apgar Score↗
PubMed1976

Effects of bis(2-ethylhexyl) phthalate on chromosomes of human leukocytes and human fetal lung cells.

Blood from two male and two female donors was exposed at 37degrees for 4 hr to concentrations of 60.0, 6.0, 0.6, and 0.06 mug of a widely used plasticizer, bis (2-ethylhexyl) phthalate, per milliliter of blood. The bis(2-ethylhexyl) phthalate was solubilized with polysorbate 80. Appropriate polysorbate and nonpolysorbate controls also were established. Following the 4 hr of incubation, phytohemagglutinin was added and tissue cultures were established. In addition, human fetal lung cells were exposed in tissue culture to a medium containing 6.0 mug/ml of bis(2-ethylhexyl) phthalate in polysorbate 80 for 5 days. Similar controls also were established for these experiments. Analysis of chromosome preparations from all cultures obtained failed to show any increased evidence of isochromatid and chromatid breaks or gaps or abnormal forms at any studied concentration when compared to the control cultures. In addition, analysis of fetal lung cell preparations for aneuploidy failed to reveal any differences between cells from study and control cultures. This study involved a short-term exposure to bis(2-ethylhexyl) phthalate in various concentrations which did not cause damage in leukocytes or fetal lung cells.

Cells, Cultured↗
PubMed1975

Some effects of diazepam on pregnancy in the Balb/C mouse.

Female Balb/C mice aged 60 to 72 days were mated with males aged 60 to 150 days and conception was diagnosed when a vaginal plug was noted. Females were randomized into five groups, Group A animals were fed a mixture of diazepam-propylene glycol which contained 0.02 mg. of diazepam in 0.1 ml. solution per day from day 1 to 9 of the gestation. Group B animals were fed the same mixture on days 5 to 12 of the gestation. Groups C and D animals were fed 0.1 ml. of propylene glycol on gestational days 1 to 9 and 5 to 12, respectively. Group E animals served as pure controls and were fed no drug or vehicle. All animals were killed on pregnancy day 15; All pups were counted, weighed, and studied grossly for anomalies. All uteri were scored for absorption sites. Nonpregnant uteri were studied histologically and scored for day of estrogen cycle. Animals fed diazepam on days 5 to 12 of gestation (Group B) had a significantly fewer number of pregnancies than did the other groups (p smaller than 0.001). In addition, pups delivered of diazepam-fed mice were heavier than control animals. No significant differences were noted, however, with respect to litter size, number of resorption sites, or presence of gross anomalies. In view of these data it would seem prudent to continue to avoid the use of diazepam during pregnancy.

Abnormalities, Drug-Induced↗
PubMed1975

Teaching pelvic examination to second-year medical students using programmed patients.

A great deal of interest has been expressed in the use of the "programmed" patient during the past several years. This pilot study used programmed patients to teach medical students the techniques of pelvic examination. From the study, it was concluded that the experience with the programmed patient adds significantly to an undergraduate learning program, that this technique is well accepted by students and faculty, and that it adds realism to the study of obstetrics and gynecology early in a medical school curriculum.

Education, Medical, Undergraduate↗