Observation of albumin deposits on teflon surfaces.
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Biomedical subjects
Publications and source records attributed to M A Wilkov.
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In recent years, significant advances have been made in treating surfaces to enhance their biocompatibility. This has generally involved the chemical attachmet of very thin molecular coatings to a substrate. Because failure of coated surfaces occurs often, an investigation of the stability of one such molecular coating was undertaken. The specific system studied is a polytetrafluoroethylene polymer (Teflon) with organic macromolecules of heparin ionically bonded to the polymer through use of an intermediate bonding agent. Polymers properly treated in this fashion have been shown to have excellent antithrombogenic properties. To investigate the molecular stability of the heparin coating, the surface heparin concentration of a properly coated sample was reduced by using three different methods: exposure of bonding agent to a suitable solvent; mechanical flexing; and ultrasonic vibration in saline solution...
Nitinol, a metal alloy which is able to remember (and return to with slight heating) the shape it had before it was deformed, is demonstrated to be useful in the Harrington rod treatment of scoliosis. A bent nitinol rod can return to its original straight length, applying both axial and lateral forces to the spine during the operation of postoperatively by means of external heating. A research program using simulated spinal forces in a test fixture and implantation in a cadaver was undertaken to show the feasibility of modifying the existing procedure.
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