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Biomedical subjects

M ATKINSON

Publications and source records attributed to M ATKINSON.

At least 19 recordsLinked to original sources
PubMed1961

Mucosal tears at the oesophagogastric junction (the Mallory-Weiss syndrome).

This is a re-appraisal of the supposedly rare Mallory-Weiss syndrome in which 11 patients with mucosal tears at the oesophagogastric junction are described. The fact that these cases were collected from general hospitals within a short period suggests that the condition is more common than supposed and may account for a considerable proportion of the 20 to 25% of patients with upper gastrointestinal bleeding in whom no radiological abnormality can subsequently be found. Of the 11 patients, eight presented with gastrointestinal bleeding, two with mediastinitis, and one without relevant symptoms. The classical history of antecedent vomiting before the bleeding was obtained in only four patients, its absence not excluding the diagnosis. The presence of a small hiatal hernia in four patients appeared to predispose to mucosal tears as did mucosal atrophy occurring with advancing age. Some experimental findings pertaining to the mechanism of the tears are presented.

Disease↗
PubMed1961

Potassium replacement therapy.

Potassium replacement is often an important therapeutic measure, and the advantages of effervescing potassium-containing granules are put forward in this article.

Biological Therapy↗
PubMed1960

Percutaneous transhepatic cholangiography.

This is an evaluation of percutaneous transhepatic cholangiography, a technique of over eight years' standing, previously considered by many authorities as both unrewarding and dangerous. The value and risks of the procedure have been examined in 20 patients with obstructive jaundice of uncertain origin and in one further patient with a post-cholecystectomy syndrome. The presence and the nature of extrahepatic obstructive lesions was correctly diagnosed in 10 of 11 patients shown to have this cause for jaundice. The failure to obtain cholangiograms in the remaining 10 patients was correctly correlated with the presence of intrahepatic obstructive disease due to hepatitis or primary biliary cirrhosis. The risks of percutaneous cholangiography seem over-rated, biliary peritonitis occurring in under 5% of patients submitted to the procedure.

Cholangiography↗