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M Abecassis

Publications and source records attributed to M Abecassis.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Immunosuppression is not required for reactivation of latent murine cytomegalovirus.

We have shown, for the first time, that TNF induces expression of MCMV IE RNA in the lungs of latently infected mice in the absence of immunosuppression. These initial data suggest that TNF may play an important role in the reactivation of latent MCMV, in the absence of immunosuppression, and provide a provocative insight into the mechanisms of CMV reactivation. Studies are in progress to determine whether genes associated with later stages of the viral life cycle are induced by TNF and whether infectious virus is produced.

Animals↗
PubMedDate not supplied

Activation of the immune coagulation system by murine hepatitis virus strain 3.

Viral infections result in alterations in hemostasis and coagulation. It has previously been shown that susceptibility to murine hepatitis virus strain 3 (MHV-3), a coronavirus, correlates directly with the spontaneous, T lymphocyte-instructed expression of a procoagulant monokine that exhibits prothrombin-cleaving activity (procoagulant activity [PCA]). A biologic role for PCA in the pathogenesis of MHV-3 infection is suggested by results of in vivo microscopic observations made during acute MHV-3 infection. Recently, it has been demonstrated that prostaglandin E2 abrogates the induction of PCA by MHV-3 both in vivo and in vitro and prevents hepatic necrosis and the associated microcirculatory changes. These data suggest that MHV-3 induces cellular injury through the activation of the coagulation cascade and provide further evidence for a role for PCA in the pathogenesis of MHV-3 infection.

Animals↗
PubMedDate not supplied

[Rhodococcus equi pneumonia in patients with AIDS].

Rhodococus equi infection is frequent in animals, but rare in humans. It usually appears as an opportunistic infection, occurring in clinical settings where a compromise of cellular immunity exists, such as in leukemia, neoplastic or transplanted patients. It is currently considered, as another opportunistic AIDS infection. Sixty six cases of Rhodococus equi pneumonia have been published until March 1996. The differential diagnosis includes TB and Staphyloccocal Pneumonia and is generally an infection which is difficult to treat, often resistant to Betalactamic drugs. Therapeutic options include an association of intracellular active antibiotics. The authors report the first Rhodococus equi pneumonia diagnosed in their Hospital and discuss the main difficulties in the diagnostic and therapeutic approach.

AIDS-Related Opportunistic Infections↗