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M Abramowicz

Publications and source records attributed to M Abramowicz.

At least 19 recordsLinked to original sources
PubMed1992

Effects of chronic congestive heart failure on 24-hour blood pressure and heart rate patterns: a hemodynamic approach.

For 29 patients with congestive heart failure (CHF), 24-hour noninvasive ambulatory blood pressure (ABP) and heart rate (HR) measurement profiles were described, using the periodogram method, and were compared with the same findings in 22 matched controls. Right-sided heart catheterization was performed in all patients. The mean cardiac index was 2.2 L/min/m2 (range 1.3 to 2.9 L/min/m2). More severe CHF, as assessed by cardiac index, pulmonary artery wedge pressure, and right atrial pressure, correlated significantly with a reduction in the amplitude of the circadian ABP and HR rhythms (0.38 less than r less than 0.63; p less than 0.05). Moreover, a reduced increase in cardiac index during cycloergometric exercise in 11 CHF patients correlated with a blunting of the circadian systolic ABP and HR profiles (0.57 less than r less than 0.90; p less than 0.05). Our results indicate that there is a reduction in the amplitude of the circadian BP and HR rhythms related to the severity of CHF.

Blood Pressure↗
PubMed1991

Intravenous diltiazem versus nitroglycerin for silent and symptomatic myocardial ischemia in unstable angina pectoris.

For 18 patients consecutively admitted to the coronary care unit for unstable angina, 48-hour electrocardiographic Holter monitoring was performed after they were randomly assigned in a single-blind fashion to 1 of 2 treatment groups. The first group was treated with acetylsalicylic acid (ASA) and intravenous nitroglycerin, the second with ASA and intravenous diltiazem. All of the patients treated with nitroglycerin still had ischemic episodes after 48 hours (33% were symptomatic), in contrast with 11% of the diltiazem group (11% asymptomatic). Maximal ST-segment depressions of symptomatic and asymptomatic episodes were significantly different; and no significant increases in heart rate were observed either during the 15 seconds before ischemia began or during the ischemic episode. During the 48 hours, the diltiazem group had significantly fewer ischemic episodes (17) than did the nitroglycerin group (145). We concluded that "on-line" ST-segment observation is of prime importance for monitoring unstable angina; that the majority of the ischemic episodes associated with unstable angina are silent; and that intravenous diltiazem could be an effective pretreatment for patients who must undergo mechanical or surgical therapy.

Aged↗
PubMed1991

High cardiac output as a paraneoplastic syndrome.

A high cardiac output (17 1 min-1) was recorded in a young man suffering from lymphoplasmatocytotic lymphoma. The evolution of the blood disease was characterized by two relapses, during which clinical signs of heart failure were prominent but resolved with efficient blood chemotherapy. The known aetiologies of high cardiac output were excluded. The complete normalization of the cardiac parameters with blood remission suggests that the high cardiac output represented an unusual paraneoplastic syndrome, the pathogenesis of which still remains unknown, although several hypotheses were tested.

Adult↗
PubMed1990

RDC8 codes for an adenosine A2 receptor with physiological constitutive activity.

The cDNA of an unidentified recently cloned G protein-coupled receptor, RDC8, has been expressed in Y1 adrenal cells, in dog thyrocytes in primary culture and in Xenopus oocytes. In all these systems this resulted in the activation of adenylyl cyclase and of the cyclic AMP cascade in the absence of any added external signal. However, this physiologically constitutive activator was inhibited by adenosine deaminase and by inhibitors of the adenosine A2 receptor. Cos 7 cells transfected with RDC8 cDNA constructs acquired binding characteristics of an adenosine A2 receptor. Moreover, RDC8 mRNA and adenosine A2 receptors display a very similar distribution in the brain. RDC8 therefore codes for an A2 adenosine receptor. Whether the physiologically constitutive activation of this receptor is entirely explained by endogeneously produced adenosine is as yet unknown.

Adenosine↗
PubMed1990

CF screening.

Explore the source record for details and available documents.

Cystic Fibrosis↗
PubMed1990

[Molecular and diagnostic genetics].

Using the recent developments of molecular biology techniques, our laboratory is offering carrier and prenatal diagnosis for a variety of genetic disorders including cystic fibrosis, phenylketonuria, thalassaemia alpha and beta, sickle cell anaemia, myotonic dystrophy, von Recklinghausen's disease, autosomal polycystic kidney disease, haemophilia A and B, Martin-Bell syndrome (fragile X), Becker and Duchenne muscular dystrophy, etc. It is likely that the rapid advances made in the establishment of the human genetic map will considerably expand the spectrum of diseases for which diagnosis by molecular genetics will become available.

Genetic Carrier Screening↗
PubMed1988

Preserved renal perfusion during beta blockade by tertatolol with and without cyclooxygenase inhibition in normal humans.

The systemic and renal hemodynamic effects of tertatolol, a new noncardioselective beta blocker without partial agonist activity, given alone or in combination with cyclooxygenase inhibition by acetylsalicylic acid (aspirin), were investigated in eight healthy volunteers. Tertatolol 5 mg, aspirin 1 g, tertatolol 5 mg together with aspirin 1 g and placebo were administered at 1-week intervals in a random order and in a double-blind fashion. Cardiac output was measured by Doppler echography and renal blood flow and glomerular filtration rate (GFR) by constant infusion techniques using (123I) iodohippurate and (51Cr) EDTA, respectively. Measurements were performed before and then successively 2 and 4 hours after oral intake of drugs or placebo. Tertatolol decreased cardiac output by 22% (P less than .05) and heart rate by 17% (P less than .05) without change in blood pressure, renal blood flow, and GFR. The same effects occurred when tertatolol was given together with aspirin. Either placebo or aspirin alone had no effect on systemic and renal hemodynamics. These results suggest that cardiac output is redistributed to the kidneys after tertatolol intake in normal humans. This favorable effect on renal hemodynamics is probably not mediated by a local release of vasodilating prostaglandins.

Adult↗
PubMed1988

Acute effects of tertatolol and nadolol on systemic and renal hemodynamics in patients with essential hypertension.

The acute systemic and renal hemodynamic effects of tertatolol, a new noncardioselective beta-blocker without partial agonist activity, were compared to those of an equipotent dose of nadolol in eight patients with essential hypertension. Tertatolol (5 mg) or nadolol (80 mg) were administered orally at an interval of 1 week in a random order as a double-blind, cross-over study. Cardiac output was measured by Doppler echography, and renal blood flow and glomerular filtration rate were measured by constant infusion techniques using 123I-iodohippurate and 51CR-EDTA, respectively. Measurements were performed before and then successively 2 and 4 hours after ingestion of the drugs. Both nadolol and tertatolol decreased blood pressure and cardiac output to a comparable extent. Renal blood flow remained unchanged, so that the renal fraction of cardiac output increased from 14.4 +/- 1.5% to 21.3 +/- 2% after nadolol and from 14.8 +/- 2.4% to 20.5 +/- 1.8% after tertatolol (mean +/- SE, P less than 0.01 before vs. after; nadolol vs. tertatolol was not significant). The glomerular filtration rate remained unchanged, from 68 +/- 9 to 64 +/- 6 mL/min.m2 after nadolol and from 71 +/- 8 to 67 +/- 7 mL/min.m2 after tertatolol (before vs. after and nadolol vs. tertatolol levels were not significant). These results show that both tertatolol and nadolol redistribute cardiac output to the kidneys in patients with essential hypertension.

Adult↗
PubMed1987

Protection against ischemic heart disease in the Belgian Physical Fitness Study: physical fitness rather than physical activity?

Occupational and leisure time physical activity and conventional risk factors were determined in the Belgian Physical Fitness Study, a prospective study of 2,363 healthy male factory workers who were aged 40-55 years at entry in 1976-1978 and who were followed for five years. Physical fitness, defined as the interpolated physical working capacity at heart rate 150 beats per minute, was measured in 2,109 subjects. In this subgroup, there were 31 myocardial infarctions and sudden deaths. Smoking, physical fitness, and high density lipoprotein cholesterol (HDL cholesterol) were independent risk indicators for subsequent ischemic heart disease, while both physical activity scores were not. It is concluded that in this healthy, predominantly sedentary population, the fitness level, but not the physical activity pattern, is an independent protective factor against ischemic heart disease.

Adult↗
PubMed1987

Comparison of the immediate effects of two beta-blocking drugs: a nonselective and a cardioselective with modest ISA in exercise-induced angina.

To compare the effects of two beta-blocking drugs: a nonselective (propranolol) and a cardioselective with modest intrinsic sympathomimetic activity (visacor), 24 patients with stable angina pectoris performed a control exercise (without medication) on a bicycle ergometer (increments of 30 W every 3 min), and thereafter were randomized to receive either propranolol (40 mg t.i.d.) or visacor (200 mg once daily) for a 48-hour double-blind trial. The 2 groups on control exercise were similar with regard to their exercise tolerance: 7.6 +/- 2.3 versus 7.1 +/- 1.4 min (NS) and the behavior of heart rate, systolic, diastolic blood pressure and double product, at rest and during exercise. They exercised on the 2nd day 2 h after the intake of propranolol or visacor. In the 12 patients randomized to propranolol, heart rate, systolic and diastolic pressures, double product were significantly reduced at rest, compared with control exercise: 67 +/- 8 versus 81 +/- 10 beats/min (p less than 0.01), 132 +/- 20 versus 146 +/- 21 mm Hg (p less than 0.02), 80 +/- 8 versus 88 +/- 10 mm Hg (p less than 0.02), 8,828 +/- 1,927 versus 11,863 +/- 2,138 mm Hg X min-1 (p less than 0.001), respectively. On the contrary, in the 12 patients randomized to visacor, these parameters at rest were less modified and only heart rate was significantly decreased: 71 +/- 9 versus 81 +/- 11 beats/min (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenergic beta-Antagonists↗
PubMed1986

Role of alpha-adrenergic coronary tone in exercise-induced angina pectoris.

To provide more insight into the role of alpha-adrenergic coronary tone in exercise-induced angina, 9 patients with chronic stable angina underwent after coronary angiography a symptom-limited supine exercise test on a cyclo-ergometer. After recovery, phentolamine was directly injected into the most diseased vessel (2 mg in 5 minutes), and immediately thereafter the same exercise (identical workloads and exercise duration) was repeated. During exercise 1, heart rate (HR), mean blood pressure and cardiac index increased 51% (p less than 0.001), 23% (p less than 0.01) and 33% (p less than 0.01), respectively, and pulmonary artery wedge pressure (PA wedge) increased from 9 +/- 1 to 26 +/- 2 mm Hg (p less than 0.001). After intracoronary injection of phentolamine, control values (including PA wedge) at rest did not change significantly. During exercise 2, HR, mean blood pressure and cardiac index increased in a similar way--50% (p less than 0.001), 25% (p less than 0.01) and 40% (p less than 0.01), respectively; however the increase in PA wedge was less (p less than 0.01). ST-segment depression at the end of exercise 2 was smaller for identical workloads and double products: 1.5 +/- 0.3 mm vs 2.5 +/- 0.3 mm (p less than 0.01). ST/HR slope in exercise 2 also decreased 51% (p less than 0.01). These results show a less severe ischemic response after intracoronary alpha blockade and argue for an improvement in coronary blood supply.

Adrenergic alpha-Antagonists↗
PubMed1986

[Hemodynamic effects of microencapsulated delayed-release nitroglycerin in acute myocardial infarction].

The hemodynamic effects following an oral dose of 19.5 mg of nitroglycerin microencapsulated to give prolonged release have been studied in 10 patients during the 48 hours which followed the establishment of a myocardial infarct complicated by moderate left cardiac insufficiency. The right auricular pressure and the pulmonary capillary pressure diminished significantly 20 minutes after the dose; 4 hours later the persistence of these effects is significant. A transient diminution of the systolic arterial pressure was observed initially (p less than 0.05). We observed that the cardiac index tends to increase although the increase did not attain the threshold of significance. No difference was observed in cardiac frequency, diastolic and mean arterial pressure and in the systemic vascular resistance. We conclude that in the patient presenting an acute myocardial infarct, 19.5 mg of NTG, microencapsulated to give prolonged release, essentially produce a reduction of the preload, with an early onset of action and a hemodynamic efficacy lasting at least 4 hours.

Aged↗
PubMed1986

Parathyroid adenoma causing persistent hypercalcaemia after rhabdomyolysis-induced acute renal failure.

Persistent hypercalcaemia developed in a 26-year-old man after rhabdomyolysis-induced acute renal failure. Although several serum parathyroid values were normal following recovery of renal function, primary hyperparathyroidism was suspected after 9 months of prolonged hypercalcaemia. A single parathyroid adenoma was removed and serum calcium as well as serum parathyroid hormone returned to normal values. The persistence of increased serum calcium concentrations after rhabdomyolysis-induced acute renal failure should lead one to consider other causes of hypercalcaemia, and particularly primary hyperparathyroidism.

Acute Kidney Injury↗
PubMed1986

[Effects of physical training on the denervated human heart after orthotopic cardiac transplantation].

Three patients who had undergone an orthotopic cardiac transplantation followed a course of supervised intermittent physical training (60 to 80 per cent of the maximum load) involving three weekly sessions of thirty minutes, for a period of 150 +/- 80 days. During maximal effort, we observed increases of 50 per cent in the load in watts (0.05 less than p less than 0.1), 40 per cent in oxygen consumption (0.1 less than p less than 0.2), 10 per cent in heart rate (p = 0.5) and 21 per cent in systolic blood pressure (0.7 less than p less than 0.8). The respiratory equivalent for oxygen decreased by 21 per cent (0.025 less than p less than 0.05) and the respiratory quotient by 5 per cent (0.4 less than p less than 0.05). For a given submaximal effort (30 watts) the following decreases were observed: 9 per cent in oxygen consumption (V'O2) (0.1 less than p less than 0.2), 32 per cent in the minute ventilation (V'E) (0.05 less than p less than 0.1), 22 per cent in the respiratory equivalent for oxygen (REO2) (0.025 less than p less than 0.05), 8 per cent in the respiratory quotient (RQ) (0.2 less than p less than 0.3) and 11 per cent in the heart rate (HR) (0.1 less than p less than 0.2). The systolic blood pressure (SBP) increased by 6 per cent (0.2 less than p less than 0.3). No changes were observed in these parameters in the postoperative follow-ups (10 to 24 months) of two patients who did not undergo physical training. Physical training is, therefore, necessary in the process of physical readaptation of patients after orthotopic cardiac grafts.

Adult↗