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Biomedical subjects

M Agathos

Publications and source records attributed to M Agathos.

11 recordsLinked to original sources

[Quality control in epicutaneous testing--reproducibility in the right-left comparison].

In 121 patients, 26 substances of a standard test battery were applied symmetrically on both sides of the upper back. The Finn chamber on Scanpor was the test system used, the final reading being taken on day 3 or 4. Of 166 tests, 131 were positive on both sides. Test substances and patients age had no influence. In comparison with the results in the literature, ours show a good reproducibility of 78.9%. Doubtful reactions (?+) were difficult to evaluate. These reactions deserve future research.

Adolescent

[Behavior and attitude regarding skin cancer prevention and early detection in relation to current knowledge--studies of visitors to an industrial fair].

During the course of the 42nd International Trade Fair 1990 in Munich a total of 1245 visitors were interrogated with regard to their education in the early recognition of skin cancer, and their behaviour in respect of exposure to sunlight. The same persons were also subjected to melanoma screening, both with regard to special assessment of pigment lesions and inspection of the entire skin. The questionnaire showed that women were better informed than men. Approximately 87% of the questioned women had heard of the problems of melanoma, whereas only about 55% of the men belonged to the informed group. The knowledge of cancer education proved to be above average in the age group between 30 and 60 years. Persons with ample knowledge on melanoma education demonstrated more motivation to take part in cancer prevention examinations and also in examinations relating to other organ systems. Thus, the necessity of cancer screening examinations was substantially more often a matter of course among women than among men. The occurrence of skin cancer on the own body as well as its occurrence in members of one's own family does not guarantee essential knowledge on melanoma education, although in the informed group the percentage of persons directly or indirectly affected by melanoma, was higher. With regard to the behaviour towards sunlight, young people dealt more cautiously and consciously with the sun than those aged 45 and over who had exposed themselves to sunlight without exercising any caution, especially in the past.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult

[The formaldehyde problem].

Regarding formaldehyde (FA), we face the following problems: (1) It is a wide-spread substance being found as free FA, in FA releasers and FA resins. (2) FA contact allergy occurs either as occupational or non-occupational disease. (3) In spite of its frequency there are still problems concerning patch testing of FA. We report on the results of patch testing with FA in various vehicles and concentrations performed on patients with dermatitis and those suffering from a proven FA contact allergy. Our investigations confirm the superiority of water as a vehicle.

Dermatitis, Contact

[Post-therapeutic benzoyl peroxide contact allergy in ulcus cruris patients].

Of 739 dermatitis patients, 4.1% showed a positive patch test reaction to benzoyl peroxide 1% in petrolatum. Forty-one patients with leg ulcers (patch test: negative to benzoyl peroxide) were treated with a 20% benzoyl peroxide emulsion for 4 weeks. After this therapy, the sensitization rate was as high as that for the maximization test, namely 76%. In most patients, the post-therapeutic allergy to benzoyl peroxide was accompanied by contact allergies to other therapeutic agents applied. Only 9 of 31 sensitized patients showed a monovalent benzoyl peroxide allergy. From the allergologic point of view, benzoyl peroxide cannot be recommended for the treatment of leg ulcers. However, there appears to be no danger in the treatment of acne vulgaris.

Administration, Topical

[Contact allergy to tromantadine].

Though infection with herpes simplex virus is one of the most common infections, there has not been causal topical treatment until now. Since 1973 tromantadine HCl (in the following briefly called tromantadine) has been offered as a topical virustatic agent. Only three years later, in 1976, there were the first reports of allergic contact dermatitis due to tromantadine. 19 patients with dermatitis after application of tromantadine ointment were patch-tested and in 14 of them a contact allergy to tromantadine was observed. In 119 patients who were patch-tested because of various dermatoses, tromantadine and the gel base were patch-tested additionally. Two positive reactions to the active substance and two to the gel base only were found. One of the latter patients also had a positive reaction to parabens. The results are discussed and compared with the results of other authors.

Adult

[Hand dermatitis in medical personnel].

Eczema (dermatitis) of the hands of medical personnel is a common skin disease. Occupational dermatitis of the hands arises from frequent contact with irritants and sensitizing agents. Differential diagnosis in hand eczema is usually only possible from the case history. One diagnostic tool is the screening of relevant contact allergies by patch-testing. The most frequent allergen in 114 cases of eczema of the hands in medical personnel between 1976 and 1980 at the Department of Dermatology and Allergology of the Municipal Hospital Schwabing in Munich was formaldehyde in 24 instances (i.e. 21%), thiuram mix in 18 (i.e. 16%) and nickel sulfate in 15 (i.e. 13%).

Dermatitis, Contact

[Toxic ulcerative contact dermatitis due to prefabricated concrete (cement burns)].

In the present report the case of a toxic ulcerous contact dermatitis (cement burns) by pre-fabricated concrete is described. This can be clearly distinguished by anamnesis, findings and development from the allergic and cumulative-toxic contact dermatitis caused by cement and related substances. It is pointed out, that in the few cases of "cement burns" made known up to now, pre-fabricated concrete was always the triggering agent.

Burns, Chemical