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Biomedical subjects

M Akai

Publications and source records attributed to M Akai.

At least 109 records · Page 6Linked to original sources
PubMed1981

[The study of washing operative wound with amikacin sulfate solution in the orthopedic surgery].

For the purpose of preventing postoperative orthopedic infections, investigation was carried out on effectiveness and safety of amikacin (AMK) after washing wound surface with its solution. 500 ml saline solution containing 400 mg AMK was used for washing. As the result, no postoperative infections were observed in all the 19 patients operated in our department. Neither abnormal findings to be regarded as abnormalities in blood test nor side-effects caused by washing were also observed. The blood samples obtained after washing did not show measurable AMK in all cases. It is said that use of antibiotics with 1) a wide-range of spectrum, 2) a bactericidal action and 3) low cross resistance against other antibiotics is preferable in washing wound surface in order to prevent postoperative infections. Under these circumstances, administration of aminoglycoside antibiotics is used frequently. Concerning the use of aminoglycoside antibiotics, however, it is necessary to pay attention to auditory and renal impairment. The previous study has revealed that AMK is lower in auditory and renal toxicity than other aminoglycoside antibiotics. AMK is thought, therefore, to be free from fear of auditory and renal impairment after washing and also to be one of effective antibiotics.

Adolescent↗
PubMed1977

Membranous lipodystrophy: a clinicopathological study of six cases.

Membranous lipodystrophy apparently is a new disease, first reported and named by Nasu and associates 31 in 1971. We have collected six cases of this disease. The initial manifestation was articular pain at adolescence. Symmetrical changes in the bones of the extremities then appeared and the disease seemed to progress slowly with age. The younger patients exhibited only skeletal pain or fractures, while the older patients had some neuropsychiatric changes. Three of the patients died in middle age. The cystic bone lesions contained a yellow, lipid-like substance which histologically showed a characteristic membranocystic appearance. Electron microscopic study showed unique features, but biochemical analysis of the substance did not reveal a definable abnormality.

Adult↗
PubMedDate not supplied

Influences of bradykinin and substance P on the met-enkephalin-like peptide content in the rat incisor pulp.

The present study was aimed to examine possible influences of bradykinin (BK) and substance P (SP) on met-enkephalin (ME)-like peptide content in the rat incisor pulp. Des-Arg9-[Leu8]-BK, a potent BK-antagonist, significantly reduced the increased content of ME-like peptides induced by noxious stimulation, while the effect of BK-antagonist was reversed in combination with BK. Morphine decreased the increased content of ME-like peptides. Ethylketocyclazocine, a kappa-agonist, also decreased the increased content of the peptides. From these results, it was suggested that BK might be a trigger in the increase of ME-like peptide content induced by noxious stimulation and, in contrast, ME-like peptides in the pulp might inhibit BK release from the pulp in a negative feedback mechanism. On the other hand, [D-Pro2,D-Trp7,9]-SP, a potent SP-antagonist, did not show any significant influence to ME-like peptide content in the pulp. Furthermore, the content was not changed following cutting of inferior alveolar nerve. From these results, it was suggested that ME-like peptides in the pulp cells might be independent on SP-containing nerves in the pulp.

Animals↗